Výsledky vyhledávání

Lipid-linked nucleoside triphosphates for enzymatic synthesis of hydrophobic oligonucleotides with enhanced membrane anchoring efficiency

Autor: David Kodr, Erika Kužmová, Radek Pohl, Tomáš Kraus, Michal Hocek

Publikováno v: Chemical Science. 14:4059-4069

New lipid-linked 2′-deoxyribonucleoside triphosphates were synthesized and used for enzymatic construction of various lipid–oligonucleotide conjugates capable of efficient anchoring to plasma membranes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77259b767c7d69b75ebab6d0d34148e3
https://doi.org/10.1039/d2sc06718h

Zobrazit plný text záznamu

Akademický článek

Betulinic Acid Decorated with Polar Groups and Blue Emitting BODIPY Dye: Synthesis, Cytotoxicity, Cell-Cycle Analysis and Anti-HIV Profiling

Autor: David Kodr, Jarmila Stanková, Michaela Rumlová, Petr Džubák, Jiří Řehulka, Tomáš Zimmermann, Ivana Křížová, Soňa Gurská, Marián Hajdúch, Pavel B. Drašar, Michal Jurášek

Publikováno v: Biomedicines, Vol 9, Iss 9, p 1104 (2021)

Betulinic acid (BA) is a potent triterpene, which has shown promising potential in cancer and HIV-1 treatment. Here, we report a synthesis and biological evaluation of 17 new compounds, including BODIPY labelled analogues derived from BA. The analogu

Externí odkaz: https://doaj.org/article/5e863bb72c9b49ad97b6593f6a49c8e3

Zobrazit plný text záznamu

Lipid linked nucleoside triphosphates for enzymatic synthesis of hydrophobic oligonucleotides with enhanced membrane anchoring efficiency

Autor: David Kodr, Erika Kuzmova, Radek Pohl, Tomas Kraus, Michal Hocek

We designed and synthesized a series of 2’-deoxyribonucleoside triphosphates (dNTPs) bearing various lipid moieties. Fatty acid- and cholesterol-modified dNTPs proved to be substrates for KOD XL DNA polymerase in primer extension reactions. They we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfab77ed1a2348f1dea18f189379dd0d
https://doi.org/10.26434/chemrxiv-2022-nqqdn

Zobrazit plný text záznamu

Electrochemical Detection of Single-Nucleotide Polymorphism Associated with Rifampicin Resistance in

Autor: Mayreli, Ortiz, Miriam, Jauset-Rubio, Vasso, Skouridou, Diana, Machado, Miguel, Viveiros, Taane G, Clark, Anna, Simonova, David, Kodr, Michal, Hocek, Ciara K, O'Sullivan

Publikováno v: ACS Sensors

Here, we report the electrochemical detection of single-point mutations using solid-phase isothermal primer elongation with redox-labeled oligonucleotides. A single-base mutation associated with resistance to rifampicin, an antibiotic commonly used f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::281ab4ea671580dfac7ca7096ce621f0
https://pubmed.ncbi.nlm.nih.gov/34797987

Zobrazit plný text záznamu

Oxime-based 19-nortestosterone–pheophorbideaconjugate: bimodal controlled release concept for PDT

Autor: Pavel Drašar, Petr Bartůněk, Vladimíra Pavlíčková, Eliška Staňková, Zdeňka Rottnerová, Tomáš Ruml, Michal Jurášek, Kamil Záruba, Marketa Simkova, Jan Fähnrich, Silvie Rimpelová, David Sedlák, Oldřich Lapčík, David Kodr

Publikováno v: Journal of Materials Chemistry B. 7:5465-5477

Photodynamic therapy has become a feasible direction for the treatment of both malignant and non-malignant diseases. It has been in the spotlight since FDA regulatory approval was granted to several photosensitizers worldwide. Nevertheless, there are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c77d4f719c0b29c29cf94430f82349e
https://doi.org/10.1039/c9tb01301f

Zobrazit plný text záznamu

Solid-phase recombinase polymerase amplification using ferrocene-labelled dNTPs for electrochemical detection of single nucleotide polymorphisms

Autor: Mayreli Ortiz, David Kodr, Ciara K. O'Sullivan, Miriam Jauset-Rubio, Anna Simonova, Michal Hocek

Publikováno v: Biosensors and Bioelectronics

Hypertrophic cardiomyopathies (HCM) are the principal cause of sudden cardiac death in young athletes and it is estimated that 1 in 500 people have HCM. The aim of this work was to develop an electrochemical platform for the detection of HCM-associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3faa159d68035f8b3573a1533856ab
https://doi.org/10.1016/j.bios.2021.113825

Zobrazit plný text záznamu

Betulinic Acid Decorated with Polar Groups and Blue Emitting BODIPY Dye: Synthesis, Cytotoxicity, Cell-Cycle Analysis and Anti-HIV Profiling

Autor: Jarmila Stanková, Pavel Drašar, Marian Hajduch, Soňa Gurská, Ivana Křížová, Michaela Rumlová, Tomáš Zimmermann, David Kodr, Michal Jurášek, Petr Džubák, Jiří Řehulka

Publikováno v: Biomedicines, Vol 9, Iss 1104, p 1104 (2021)
Biomedicines
Volume 9
Issue 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d78bec3e4003bb695e503fef6ef39e
https://doi.org/10.3390/biomedicines9091104

Zobrazit plný text záznamu

Electrochemical Detection of Single-Nucleotide Polymorphism Associated with Rifampicin Resistance in Mycobacterium tuberculosis Using Solid-Phase Primer Elongation with Ferrocene-Linked Redox-Labeled Nucleotides

Autor: Vasso Skouridou, David Kodr, Anna Simonova, Miriam Jauset-Rubio, Diana Machado, Michal Hocek, Taane G. Clark, Mayreli Ortiz, Ciara K. O'Sullivan, Miguel Viveiros

Publikováno v: American Chemical Society Sensors
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Funding Information: This project received partial funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 767325, the Czech Science Foundation (20-00885X to M.H.), and the Fundação para a Ciênci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb14a81ef8a7022294215d5a02815f9

Zobrazit plný text záznamu

Carborane- or Metallacarborane-Linked Nucleotides for Redox Labeling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing

Autor: Radek Pohl, Dijana Pavlović Saftić, Michal Hocek, Mayreli Ortiz, Miroslav Fojta, Anna Simonova, Cansu Pinar Yenice, Zbigniew J. Lesnikowski, David Kodr, Ludĕk Havran, Veronika Sýkorová, Ciara K. O'Sullivan

Publikováno v: Journal of the American Chemical Society. 143(18):7124-7134

We report a series of 2′-deoxyribonucleoside triphosphates bearing dicarba-nido-undecaborate ([C2B9H11]1−), [3, 3′-ironbis( 1, 2-dicarbollide)]− (FESAN, [Fe(C2B9H11)2]2−) or [3, 3′-cobaltbis( 1, 2-dicarbollide)]− (COSAN, [Co(C2B9H11)2]2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf0813d388545cfd9ae63f4e15a63a8

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání