Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex

Autor: Tracy Murray-Stewart, Michael J. Gambello, Robert A. Casero, David Kapfhamer, James T. McKenna, Caroline Yoon

Publikováno v: Hum Mol Genet

Tuberous sclerosis complex (TSC) is a rare autosomal dominant neurodevelopmental disorder characterized by variable expressivity. TSC results from inactivating variants within the TSC1 or TSC2 genes, leading to constitutive activation of mechanistic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fac4693c3bbb021a1e0c63c53d9a796
https://doi.org/10.1093/hmg/ddaa121

Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex

Autor: Matthew Dunworth, Tracy Murray-Stewart, Michael J. Gambello, Brandi Wasek, Robert A. Casero, James T. McKenna, David Kapfhamer, Jason M. Kinchen, Teodoro Bottiglieri

Publikováno v: Human Molecular Genetics. 27:2113-2124

Tuberous sclerosis complex (TSC) is an autosomal dominant neurodevelopmental disorder and the quintessential disorder of mechanistic Target of Rapamycin Complex 1 (mTORC1) dysregulation. Loss of either causative gene, TSC1 or TSC2, leads to constitut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c12a1bc2aae2a874ee696c81a5939f
https://doi.org/10.1093/hmg/ddy118

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

Autor: Stephen M. Massa, Raymond A. Swanson, Yanting Chen, Yong Huang, Ji-Eun Kim, Seok Joon Won, Angela M. Minnella, Ley-Hian Low, Yiguo Shen, David Kapfhamer

Publikováno v: Shen, Y; Kapfhamer, D; Minnella, AM; Kim, J-E; Won, SJ; Chen, Y; et al.(2017). Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. NATURE COMMUNICATIONS, 8, 624. doi: 10.1038/s41467-017-00707-0. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1sz7m11h
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature communications, vol 8, iss 1
Nature Communications

The innate inflammatory response contributes to secondary injury in brain trauma and other disorders. Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflammatory response, but how this occurs is unclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5531bbd4080d13eb5d089e09acc8a0
http://www.escholarship.org/uc/item/1sz7m11h

Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1

Autor: Jianguo, Xu, Handong, Wang, Seok Joon, Won, Jayinee, Basu, David, Kapfhamer, Raymond A, Swanson

Publikováno v: Glia

Brain injury resulting from stroke or trauma can be exacerbated by the release of proinflammatory cytokines, proteases, and reactive oxygen species by activated microglia. The microglial activation resulting from brain injury is mediated in part by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0499523c4efc7734d0eae42fec0fe76
https://pubmed.ncbi.nlm.nih.gov/27444121

Loss of RAB-3/A inCaenorhabditis elegansand the mouse affects behavioral response to ethanol

Autor: Catharine L. Eastman, Emily A. Smail, Ulrike Heberlein, Steven L. McIntire, Andrew G. Davies, Jill C. Bettinger, David Kapfhamer

Publikováno v: Genes, Brain and Behavior. 7:669-676

The mechanisms by which ethanol induces changes in behavior are not well understood. Here, we show that Caenorhabditis elegans loss-of-function mutations in the synaptic vesicle-associated RAB-3 protein and its guanosine triphosphate exchange factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401ef350ba8f3ec7429adbc0dc4afabd
https://doi.org/10.1111/j.1601-183x.2008.00404.x