Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David, Jetton"'
Autor:
David Jetton, Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Rebecca Batorsky, Joan Mecsas, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114641- (2024)
Summary: Caspase-8-dependent pyroptosis has been shown to mediate host protection from Yersinia infection. For this mode of cell death, the kinase activity of receptor-interacting protein kinase 1 (RIPK1) is required, but the autophosphorylation site
Externí odkaz:
https://doaj.org/article/8f76fc38478046edb57e8621e9f53391
Autor:
Francisco J Carrillo-Salinas, Marina Anastasiou, Njabulo Ngwenyama, Kuljeet Kaur, Albert Tai, Sasha A. Smolgovsky, David Jetton, Mark Aronovitz, Pilar Alcaide
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Despite the existing association of gut dysbiosis and T cell inflammation in heart failure (HF), whether and how gut microbes contribute to T cell immune responses, cardiac fibrosis and dysfunction in HF remains largely unexplored. Our objective was
Externí odkaz:
https://doaj.org/article/0aa8c8167c05442e93b14f050c1473f7
Autor:
Hayley I. Muendlein, Wilson M. Connolly, James Cameron, David Jetton, Zoie Magri, Irina Smirnova, Edouard Vannier, Xudong Li, Amanda J. Martinot, Rebecca Batorsky, Alexander Poltorak
Publikováno v:
Sci Immunol
TNF mediates a variety of biological processes including cellular proliferation, inflammatory responses, and cell death and is therefore associated with numerous pathologies including autoinflammatory diseases and septic shock. The inflammatory and c
Autor:
Michael K McCracken, Gregory D Gromowski, Heather L Friberg, Xiaoxu Lin, Peter Abbink, Rafael De La Barrera, Kenneth H Eckles, Lindsey S Garver, Michael Boyd, David Jetton, Dan H Barouch, Matthew C Wise, Bridget S Lewis, Jeffrey R Currier, Kayvon Modjarrad, Mark Milazzo, Michelle Liu, Anna B Mullins, J Robert Putnak, Nelson L Michael, Richard G Jarman, Stephen J Thomas
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006487 (2017)
Studies have demonstrated cross-reactivity of anti-dengue virus (DENV) antibodies in human sera against Zika virus (ZIKV), promoting increased ZIKV infection in vitro. However, the correlation between in vitro and in vivo findings is not well charact
Externí odkaz:
https://doaj.org/article/60a145e92db048278177d0a157c5894e
Autor:
Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, David Jetton, Irina Smirnova, Alexei Degterev, Siddharth Balachandran, Alexander Poltorak
Publikováno v:
Proceedings of the National Academy of Sciences. 119
ZBP1 is widely recognized as a mediator of cell death for its role in initiating necroptotic, apoptotic, and pyroptotic cell death pathways in response to diverse pathogenic infection. Herein, we characterize an unanticipated role for ZBP1 in promoti
Autor:
Alexander Poltorak, Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, David Jetton, Keith P. Eidell, Irina Smirnova
Publikováno v:
Science. 367:1379-1384
Macrophages cFLIP out Pathogens have evolved to survive within hosts in part by interfering with host signaling cascades. Yersinia bacteria use the effector protein YopJ to thwart MAP kinase signaling downstream of Toll-like receptor activation. In r
Autor:
David Jetton, Rebecca E. Brown, Machika Kaku, John M. Coffin, Daria Wells, John K Yoon, Joseph R Holloway
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
In vivo clonal expansion of HIV-infected T cells is an important mechanism of viral persistence. In some cases, clonal expansion is driven by HIV proviral DNA integrated into one of a handful of genes. To investigate this phenomenon in vitro, we infe
Autor:
David Jetton, Joseph Hesselgesser, Erica N. Borducchi, Mark G. Lewis, Dan H. Barouch, Galit Alter, Peter Abbink, Edward T. Moseley, Lauren Peter, Elena Bekerman, Jinyan Liu, Joseph P. Nkolola, Noe B. Mercado, Wen-Han Yu, Abishek Chandrashekar, Thomas Broge, Romas Geleziunas, Katherine McMahan, Anthony M. Cadena, Stephanie Fischinger, Wenjun Li
Publikováno v:
Nature
The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) administered when antiret
Autor:
Crystal Cabral, Katherine Molloy, Joseph P. Nkolola, Alison L. Hill, David Jetton, Kathryn E. Stephenson, Maria G. Pau, Nelson L. Michael, Hanneke Schuitemaker, Peter Abbink, Lauren Peter, Jinyan Liu, Abishek Chandrashekar, Romas Geleziunas, Jeffrey M. Gerold, Galit Alter, Merlin L. Robb, Jessica Jimenez, Mark G. Lewis, Dan H. Barouch, Benjamin C. Lee, Jerome H. Kim, Joseph Hesselgesser, David Ng’ang’a, Erica N. Borducchi, Shanell Mojta, Amanda L. Brinkman, Jade Mondesir
Publikováno v:
Nature
The development of immunologic interventions that can target the viral reservoir in HIV-1-infected individuals is a major goal of HIV-1 research. However, little evidence exists that the viral reservoir can be sufficiently targeted to improve virolog
Autor:
Hayley I, Muendlein, David, Jetton, Wilson M, Connolly, Keith P, Eidell, Zoie, Magri, Irina, Smirnova, Alexander, Poltorak
Publikováno v:
Science
Cell death and inflammation are interdependent host responses to infection. During pyroptotic cell death, interleukin-1β (IL-1β) release occurs through caspase-1 and caspase-11–mediated gasdermin D pore formation. In vivo, responses to lipopolysa