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DG-041 inhibits the EP3 prostanoid receptor—A new target for inhibition of platelet function in atherothrombotic disease.

Autor: Heptinstall, Stan¹ (AUTHOR) s.heptinstall@nottingham.ac.uk, Espinosa, David Iyu¹ (AUTHOR), Manolopoulos, Panagiotis¹ (AUTHOR), Glenn, Jackie R.¹ (AUTHOR), White, Ann E.¹ (AUTHOR), Johnson, Andrew¹ (AUTHOR), Dovlatova, Natalia¹ (AUTHOR), Fox, Sue C.¹ (AUTHOR), May, Jane A.¹ (AUTHOR), Hermann, David² (AUTHOR), Magnusson, Olafur³ (AUTHOR), Stefansson, Kari³ (AUTHOR), Hartman, Dan² (AUTHOR), Gurney, Mark⁴ (AUTHOR)

Publikováno v: Platelets. Dec2008, Vol. 19 Issue 8, p605-613. 9p. 5 Graphs.

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DG-041 inhibits the EP3 prostanoid receptor—A new target for inhibition of platelet function in atherothrombotic disease

Autor: Stan Heptinstall, David Iyu Espinosa, Natalia Dovlatova, Jackie R. Glenn, Ann E. White, Panagiotis Manolopoulos, David Hermann, Andrew D. Johnson, Kari Stefansson, Olafur T. Magnusson, Dan Hartman, Jane A. May, Susan C. Fox, Mark E. Gurney

Publikováno v: Platelets. 19:605-613

Receptors for prostanoids on platelets include the EP3 receptor for which the natural agonist is the inflammatory mediator prostaglandin E(2) (PGE(2)) produced in atherosclerotic plaques. EP3 is implicated in atherothrombosis and an EP3 antagonist mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61efe3ae7cdee033cc43523db197c8d0
https://doi.org/10.1080/09537100802351073

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The effect of dipyridamole on vascular cell-derived reactive oxygen species

Autor: Subrata Chakrabarti, Olga Vitseva, David Iyu, Sonia Varghese, Jane E. Freedman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 315(2)

Platelet and vascular stimulation leads to release of reactive oxygen species (ROS) that are known to influence vascular reactivity and thrombosis. Dipyridamole is a vasodilator and platelet inhibitor that has previously been shown to have direct ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7e4e1ac46231d27e9f73043ebe0400
https://pubmed.ncbi.nlm.nih.gov/16046616

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Interaction of nitric oxide with calcium in the mesenteric bed of bile duct-ligated rats

Autor: F Javier A, Nadal, Noemí M, Atucha, David, Iyu, Joaquín, García-Estañ

Publikováno v: British journal of pharmacology. 135(2)

We have analysed the interaction of NO with calcium in order to study the molecular mechanisms responsible for the vascular hyporesponse of liver cirrhosis. The experiments have been performed in the isolated and perfused mesenteric arterial bed of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06e46f20b60c7957403b3077ec262907
https://pubmed.ncbi.nlm.nih.gov/11815385

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Role of vascular nitric oxide in experimental liver cirrhosis,Papel del óxido nítrico vascular en la cirrosis hepática experimental

Autor: Atucha, N. M., Nadal, F. J., David Iyu, García-Estañ, J.

Publikováno v: Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ad9239cdc9c158c5a113948f5dfde168
http://www.scopus.com/inward/record.url?eid=2-s2.0-2242490780&partnerID=MN8TOARS

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