Zobrazeno 1 - 10
of 204
pro vyhledávání: '"David, Humes"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cell directed therapy is an evolving therapeutic approach to treat organ dysfunction arising from hyperinflammation and cytokine storm by processing immune cells in an extracorporeal circuit. To investigate the mechanism of action of the Sel
Externí odkaz:
https://doaj.org/article/b825e7be3a414f3ca6f310f035866aa2
Autor:
Sai Prasad N. Iyer, PhD, Christopher J. Pino, PhD, Lenar T. Yessayan, MD, Stuart L. Goldstein, MD, Matthew R. Weir, MD, Angela J. Westover, BS, David A. Catanzaro, PharmD, Kevin K. Chung, MD, H. David Humes, MD
Publikováno v:
Transplantation Direct, Vol 10, Iss 6, p e1627 (2024)
A stable, minimum physiological health status is required for patients to qualify for transplant or artificial organ support eligibility to ensure the recipient has enough reserve to survive the perioperative transplant period. Herein, we present a n
Externí odkaz:
https://doaj.org/article/26274fe23cf24edd81834180c8fbe26f
Autor:
Stuart L. Goldstein, Nicholas J. Ollberding, David J. Askenazi, Rajit K. Basu, David T. Selewski, Kelli A. Krallman, Lenar Yessayan, Harvey David Humes
Publikováno v:
Kidney Medicine, Vol 6, Iss 4, Pp 100792- (2024)
Rationale and Objective: Critically ill children with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) are at increased risk of death. The selective cytopheretic device (SCD) promotes an immunomodulatory effect at circu
Externí odkaz:
https://doaj.org/article/41a2b363a5c2403eb168893ceb08269e
Autor:
Eun Jung Kim, Caressa Chen, Rebecca Gologorsky, Ana Santandreu, Alonso Torres, Nathan Wright, Mark S. Goodin, Jarrett Moyer, Benjamin W. Chui, Charles Blaha, Paul Brakeman, Shant Vartanian, Qizhi Tang, H. David Humes, William H. Fissell, Shuvo Roy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The definitive treatment for end-stage renal disease is kidney transplantation, which remains limited by organ availability and post-transplant complications. Alternatively, an implantable bioartificial kidney could address both problems whi
Externí odkaz:
https://doaj.org/article/0d211e11b47246acb10abcd7f2c4c868
Autor:
H. David Humes, MD, Stuart L. Goldstein, MD, Lenar T. Yessayan, MD, David A. Catanzaro, PharmD, Emily C. Scribe, PharmD, Sai Prasad N. Iyer, PhD, Kevin K. Chung, MD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 10, p e0995 (2023)
OBJECTIVES:. Acute kidney injury (AKI) requiring continuous kidney replacement therapy is a significant complication in ICU patients with mortality rates exceeding 50%. A dysregulated immune response can lead to systemic inflammation caused by hypera
Externí odkaz:
https://doaj.org/article/ae437b8cebe34d67a9023f8e7b1ab77e
Autor:
H David Humes, Keith D Aaronson, Deborah A Buffington, Hani N Sabbah, Angela J Westover, Lenar T Yessayan, Balazs Szamosfalvi, Francis D Pagani
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0273138 (2023)
BackgroundInflammation has been associated with progression and complications of chronic heart failure (HF) but no effective therapy has yet been identified to treat this dysregulated immunologic state. The selective cytopheretic device (SCD) provide
Externí odkaz:
https://doaj.org/article/fe30b57e5ebe42d6b93f04af21250879
Autor:
Lenar Yessayan, Ryann Sohaney, Vidhit Puri, Benjamin Wagner, Amy Riddle, Sharon Dickinson, Lena Napolitano, Michael Heung, David Humes, Balazs Szamosfalvi
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Regional citrate anticoagulation (RCA) for the prevention of clotting of the extracorporeal blood circuit during continuous kidney replacement therapy (CKRT) has been employed in limited fashion because of the complexity and compl
Externí odkaz:
https://doaj.org/article/28e39ead45204651b93e5640433fd108
Autor:
Lenar T. Yessayan, MD, MS, Javier A. Neyra, MD, MS, Angela J. Westover, BS, Balazs Szamosfalvi, MD, H. David Humes, MD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 5, p e0694 (2022)
OBJECTIVES:. To evaluate safety and clinical outcomes of extracorporeal immunomodulation treatment with a selective cytopheretic device (SCD) in COVID-19 ICU patients with multiple organ failure. DESIGN:. Two-center, prospective, single-arm treatment
Externí odkaz:
https://doaj.org/article/bee3ca73fad841e98e6f7d1d9dc4db61
Publikováno v:
BMJ Open, Vol 12, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/83d5be428859402ea78b2eabbc61b65e
Autor:
H. David Humes, Angela J. Westover
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/6105c3b6c54847369aaa9b95ec3a1a77