Zobrazeno 1 - 10
of 660
pro vyhledávání: '"David, Horn"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Although genome-wide polycistronic transcription places major emphasis on post-transcriptional controls in trypanosomatids, messenger RNA cis-regulatory untranslated regions (UTRs) have remained largely uncharacterised. Here, we describe a g
Externí odkaz:
https://doaj.org/article/33cb6962a551462faf5258253779e7b0
Autor:
Joana R. C. Faria, Michele Tinti, Catarina A. Marques, Martin Zoltner, Harunori Yoshikawa, Mark C. Field, David Horn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG exclusion-factor-2 (VEX2), a UPF1-related protein in the African
Externí odkaz:
https://doaj.org/article/16ff35d784f44ce5b0d4ec6740ef38bd
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0012007 (2024)
Trypanosoma brucei is a causative agent of the Human and Animal African Trypanosomiases. The mammalian stage parasites infect various tissues and organs including the bloodstream, central nervous system, skin, adipose tissue and lungs. They rely on A
Externí odkaz:
https://doaj.org/article/80c616d10ccd4ebb9a94e244ed85dd6a
The EPMOW Genre volumes contain entries on the genres of music that have been or currently are popular in countries and communities all over the world. Included are discussions on cultural, historical and geographic origins; technical musical charact
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Progression of the canonical eukaryotic cell cycle is tightly regulated. While the cell cycle control of flagellated protozoa Trypanosoma brucei shares conserved features with other eukaryotes certain cell cycle checkpoints are absent. Here, Marques
Externí odkaz:
https://doaj.org/article/8280850909f14bf194bd49b8a55c126f
Autor:
Sabine Bachmaier, Matthew K. Gould, Eleni Polatoglou, Radoslaw Omelianczyk, Ana E. Brennand, Maha A. Aloraini, Jane C. Munday, David Horn, Michael Boshart, Harry P. de Koning
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Cyclic AMP signalling in trypanosomes differs from most eukaryotes due to absence of known cAMP effectors and cAMP independence of PKA. We have previously identified four genes from a genome-wide RNAi screen for resistance to the cAMP phosphodiestera
Externí odkaz:
https://doaj.org/article/a23c0cd921084cd7b7799b4ed7628644
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Inversion Symmetry is a generalization of the second Chargaff rule, stating that the count of a string of k nucleotides on a single chromosomal strand equals the count of its inverse (reverse-complement) k-mer. It holds for many s
Externí odkaz:
https://doaj.org/article/c36aa37beb684e389301d092002ab164
Publikováno v:
mSphere, Vol 7, Iss 2 (2022)
ABSTRACT Variant surface glycoproteins (VSGs) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. These VSGs are superabundant virulence factors that are subject to posttranscriptional gene expression controls med
Externí odkaz:
https://doaj.org/article/8a3fa1d9e73441a59fe9f92cf3253f6e
Autor:
David Horn
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010040 (2022)
The parasitic trypanosomatids cause lethal and debilitating diseases, the leishmaniases, Chagas disease, and the African trypanosomiases, with major impacts on human and animal health. Sustained research has borne fruit by assisting efforts to reduce
Externí odkaz:
https://doaj.org/article/dd89996abc9a4290bb9a59247128a997
Autor:
Erin Barillier, Victoria Grinberg, David Horn, Michael A. Nowak, Ronald A. Remillard, James F. Steiner, Dominic J. Walton, Jörn Wilms
Publikováno v:
The Astrophysical Journal, Vol 944, Iss 2, p 165 (2023)
4U 1957+11 is a black hole candidate system that has been in a soft X-ray spectral state since its discovery. We present analyses of recent joint NICER and NuSTAR spectra, which are extremely well described by a highly inclined disk accreting into a
Externí odkaz:
https://doaj.org/article/95833e0cb8b54d679b05823a562d4917