Zobrazeno 1 - 10
of 59
pro vyhledávání: '"David, Hedley"'
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-19 (2020)
Abstract Background Epidermal growth factor receptors (EGFR) are overexpressed on > 90% of pancreatic cancers (PnCa) and represent an attractive target for the development of novel therapies, including radioimmunotherapy (RIT). Our aim was to study R
Externí odkaz:
https://doaj.org/article/945e2356dc0843e299a516643d1e44a3
Autor:
Kyaw L. Aung, Elaine McWhirter, Stephen Welch, Lisa Wang, Sophia Lovell, Lee-Anne Stayner, Saara Ali, Anne Malpage, Barbara Makepeace, Makilpriya Ramachandran, Gun Ho Jang, Steven Gallinger, Tong Zhang, Tracy L. Stockley, Sandra E. Fischer, Neesha Dhani, David Hedley, Jennifer J. Knox, Lillian L. Siu, Rachel Goodwin, Philippe L. Bedard
Publikováno v:
Journal of Gastrointestinal Oncology. 13:3216-3226
Autor:
Deena M A Gendoo, Robert E Denroche, Amy Zhang, Nikolina Radulovich, Gun Ho Jang, Mathieu Lemire, Sandra Fischer, Dianne Chadwick, Ilinca M Lungu, Emin Ibrahimov, Ping-Jiang Cao, Lincoln D Stein, Julie M Wilson, John M S Bartlett, Ming-Sound Tsao, Neesha Dhani, David Hedley, Steven Gallinger, Benjamin Haibe-Kains
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006596 (2019)
Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among solid malignancies and improved therapeutic strategies are needed to improve outcomes. Patient-derived xenografts (PDX) and patient-derived organoids (PDO) serve as promising tools
Externí odkaz:
https://doaj.org/article/db08daf61ce64bfbb21f930f5552d95d
Autor:
Jennifer J. Knox, Steven Gallinger, Malcolm J. Moore, Julie M. Wilson, Faiyaz Notta, David Hedley, Neesha Dhani, Paul M. Krzyzanowski, Lee Timms, Jen Jen Yeh, Richard A. Moffitt, Ashton A. Connor, Spring Holter, Mathieu Lemire, Sangeet Ghai, John M.S. Bartlett, Ilinca M. Lungu, Danielle Pasternack, Faridah Mbabaali, Jessica K. Miller, Robert C. Grant, Shari Moura, Hamzeh Albaba, Grainne M. O'Kane, Amy Zhang, Dianne Chadwick, Sheng-Ben Liang, Bernadette Southwood, Sean Creighton, Anna Dodd, Gun-Ho Jang, Robert E. Denroche, Sandra E. Fischer, Kyaw L. Aung
Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational and transcriptional features for better treatment selection.Experimental Des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbe8fc5dfab94ff81688a693a53d954
https://doi.org/10.1158/1078-0432.c.6524567.v1
https://doi.org/10.1158/1078-0432.c.6524567.v1
Autor:
Jennifer J. Knox, Steven Gallinger, Malcolm J. Moore, Julie M. Wilson, Faiyaz Notta, David Hedley, Neesha Dhani, Paul M. Krzyzanowski, Lee Timms, Jen Jen Yeh, Richard A. Moffitt, Ashton A. Connor, Spring Holter, Mathieu Lemire, Sangeet Ghai, John M.S. Bartlett, Ilinca M. Lungu, Danielle Pasternack, Faridah Mbabaali, Jessica K. Miller, Robert C. Grant, Shari Moura, Hamzeh Albaba, Grainne M. O'Kane, Amy Zhang, Dianne Chadwick, Sheng-Ben Liang, Bernadette Southwood, Sean Creighton, Anna Dodd, Gun-Ho Jang, Robert E. Denroche, Sandra E. Fischer, Kyaw L. Aung
Supplementary Methods, Tables and Figures Supplementary Table 1: Summary of whole genome sequencing results including performance metrics and time to reporting (N=62). Supplementary Table 2: Summary of GATA6 RNA in situ results and its correlation wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e10b211fb98f6ea7d8674050f196d6
https://doi.org/10.1158/1078-0432.22460684
https://doi.org/10.1158/1078-0432.22460684
Autor:
Francesco Fazzari, Sue Chow, May Cheung, Samir H. Barghout, Aaron D. Schimmer, Qing Chang, David Hedley
Publikováno v:
ACS pharmacologytranslational science. 5(11)
Pancreatic ductal adenocarcinoma is characterized by increased generation of reactive oxygen species that can cause lethal oxidative stress. Here, we evaluated the combined inhibition of the glutathione and thioredoxin antioxidant systems in preclini
TMIC-73. HIGH-DIMENSIONAL HISTOPATHOLOGIC EVALUATION OF THE HYPOXIC MICROENVIRONMENT IN GLIOBLASTOMA
Autor:
Sheila Mansouri, Mark Zaidi, Olivia Singh, Hafsah Ali, Shirin Karimi, Phoebe Lombard, Anna Dvorkin-Gheva, Carlos Velasquez, Kaviya Devaraja, Julio Sosa, Vikas Patil, Qingxia Wei, Ronald Wu, Mira Li, May Cheung, Mathew Voisin, Andrew Gao, David Hedley, Kenneth Aldape, Bradly Wouters, Gelareh Zadeh
Publikováno v:
Neuro-Oncology. 24:vii287-vii288
Rapidly growing solid tumors such as glioblastoma (GBM) are characteristically hypoxic, displaying large areas of necrosis surrounded by hyperproliferative pseudopalisading cells. Intra-tumoral hypoxia develops over time in the three-dimensional spac
Autor:
Mark K. Doherty, Vincent C. Tam, Mairéad G. McNamara, Raymond Jang, David Hedley, Eric Chen, Neesha Dhani, Patricia Tang, Hao-Wen Sim, Grainne M. O’Kane, Stephanie DeLuca, Lisa Wang, Theresa Pedutem, Jennifer J. Knox
Publikováno v:
British journal of cancer. 127(8)
Cisplatin and gemcitabine (CisGem) are standard chemotherapy for advanced biliary tract cancer (BTC). The MEK inhibitor selumetinib showed synergy with gemcitabine when administered sequentially in BTC. This randomised Phase 2 trial aimed to assess t
Autor:
Ali Hosni, Jolie Ringash, Kathy Han, Zhihui (Amy) Liu, James D. Brierley, Rebecca K.S. Wong, Laura A. Dawson, Bernard J. Cummings, Monika K. Krzyzanowska, Eric X. Chen, David Hedley, Jennifer J. Knox, Alexandra M. Easson, Patricia Lindsay, Tim Craig, John Kim
Publikováno v:
Diseases of the colon and rectum. 65(5)
Maintaining and improving quality of life (QOL) are important goals of anal cancer management. This disease is generally curable, with many long-term survivors.Long-term QOL after chemoradiation for patients with anal cancer was evaluated.This was a