Zobrazeno 1 - 10
of 818
pro vyhledávání: '"David, Hawkins"'
Autor:
Arpit Mishra, Ajay Jajodia, Eryn Weston, Naresh Doni Jayavelu, Mariana Garcia, Daniel Hossack, R. David Hawkins
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type I diabetes is an autoimmune disease mediated by T-cell destruction of β cells in pancreatic islets. Currently, there is no known cure, and treatment consists of daily insulin injections. Genome-wide association studies and twin studies have ind
Externí odkaz:
https://doaj.org/article/289347cc65d04d078c937b222b6228b9
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Identification of silencer elements by computational or experimental approaches in a genome-wide manner is still challenging. Here authors define uncharacterized cis-regulatory elements (CREs) in human and mouse genomes likely containing silencer ele
Externí odkaz:
https://doaj.org/article/4f3605d087a948f498561d56217e2e9a
Autor:
Petri Rummukainen, Kati Tarkkonen, Amel Dudakovic, Rana Al-Majidi, Vappu Nieminen-Pihala, Cristina Valensisi, R. David Hawkins, Andre J. van Wijnen, Riku Kiviranta
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Epigenetic mechanisms regulate osteogenic lineage differentiation of mesenchymal stromal cells. Histone methylation is controlled by multiple lysine demethylases and is an important step in controlling local chromatin structure and gene expression. H
Externí odkaz:
https://doaj.org/article/7426cb3eed9b46dfa425198e3ca407af
Autor:
Calvin Jon A Leonen, Miho Shimada, Caroline E Weller, Tomoyoshi Nakadai, Peter L Hsu, Elizabeth L Tyson, Arpit Mishra, Patrick MM Shelton, Martin Sadilek, R David Hawkins, Ning Zheng, Robert G Roeder, Champak Chatterjee
Publikováno v:
eLife, Vol 10 (2021)
The post-translational modification of histones by the small ubiquitin-like modifier (SUMO) protein has been associated with gene regulation, centromeric localization, and double-strand break repair in eukaryotes. Although sumoylation of histone H4 w
Externí odkaz:
https://doaj.org/article/30279bf7f3df4f09aea9e207bc1fc733
Publikováno v:
Epigenetics, Vol 14, Iss 8, Pp 780-790 (2019)
Assisted reproductive technologies are known to alter the developmental environment of gametes and early embryos during the most dynamic period of establishing the epigenome. This may result in the introduction of errors during active DNA methylation
Externí odkaz:
https://doaj.org/article/819c8eaf94fd4369b2ee3afdac51e24a
Autor:
Stephanie L. Battle, Naresh Doni Jayavelu, Robert N. Azad, Jennifer Hesson, Faria N. Ahmed, Eliah G. Overbey, Joseph A. Zoller, Julie Mathieu, Hannele Ruohola-Baker, Carol B. Ware, R. David Hawkins
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 1129-1144 (2019)
Summary: During mammalian embryogenesis, changes in morphology and gene expression are concurrent with epigenomic reprogramming. Using human embryonic stem cells representing the preimplantation blastocyst (naive) and postimplantation epiblast (prime
Externí odkaz:
https://doaj.org/article/a4701e94f0d8402a95a19165a7d8c1db
Autor:
Eliah G. Overbey, Theros T. Ng, Pietro Catini, Lisa M. Griggs, Paul Stewart, Suzana Tkalcic, R. David Hawkins, Yvonne Drechsler
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
While the chicken (Gallus gallus) is the most consumed agricultural animal worldwide, the chicken transcriptome remains understudied. We have characterized the transcriptome of 10 cell and tissue types from the chicken using RNA-seq, spanning intesti
Externí odkaz:
https://doaj.org/article/8b1b93aad9cd4694b3de426ee3becbde
Autor:
Bo Yu, Naresh Doni Jayavelu, Stephanie L Battle, Jessica C Mar, Timothy Schimmel, Jacques Cohen, R David Hawkins
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241698 (2020)
Oocyte maturation is a coordinated process that is tightly linked to reproductive potential. A better understanding of gene regulation during human oocyte maturation will not only answer an important question in biology, but also facilitate the devel
Externí odkaz:
https://doaj.org/article/09616ac32edb4f0e9504bb5cdaa72d23
Autor:
Edward Litton, Stuart Baker, Wendy Erber, Shannon Farmer, Janet Ferrier, Craig French, Joel Gummer, David Hawkins, Alisa Higgins, Axel Hofmann, Bart De Keulenaer, Julie McMorrow, John K. Olynyk, Toby Richards, Simon Towler, Robert Trengove, Steve Webb, on behalf of the IRONMAN Study investigators, the Australian and New Zealand Intensive Care Society Clinical Trials Group
Publikováno v:
Journal of Intensive Care, Vol 6, Iss 1, Pp 1-7 (2018)
Abstract Background Both anaemia and red blood cell (RBC) transfusion are common and associated with adverse outcomes in patients admitted to the intensive care unit (ICU). The aim of this study was to determine whether serum hepcidin concentration,
Externí odkaz:
https://doaj.org/article/9bb5bfed9498423e9abb4dc00650dd2f
Autor:
Kalyan K. Pasumarthy, Naresh Doni Jayavelu, Lotta Kilpinen, Colin Andrus, Stephanie L. Battle, Matti Korhonen, Petri Lehenkari, Riikka Lund, Saara Laitinen, R. David Hawkins
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 999-1015 (2017)
Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion prior to use as cell-based therapies in immunological and tissue repair applications. Aging and expansion of BM-MSCs induce epigenetic changes that can impact therap
Externí odkaz:
https://doaj.org/article/80d7d5cb651d41fb81bde32a77bc6257