Zobrazeno 1 - 10
of 243
pro vyhledávání: '"David, Gisselsson"'
Autor:
Jenny Karlsson, Hiroaki Yasui, Adriana Mañas, Natalie Andersson, Karin Hansson, Kristina Aaltonen, Caroline Jansson, Geoffroy Durand, Naveen Ravi, Michele Ferro, Minjun Yang, Subhayan Chattopadhyay, Kajsa Paulsson, Diana Spierings, Floris Foijer, Anders Valind, Daniel Bexell, David Gisselsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Neuroblastoma (NB) is one of the most lethal childhood cancers due to its propensity to become treatment resistant. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that de
Externí odkaz:
https://doaj.org/article/fe608167f7ff46d5b574d7aead9ed289
Autor:
Anders Valind, Bronte Manouk Verhoeven, Jens Enoksson, Jenny Karlsson, Gustav Christensson, Adriana Mañas, Kristina Aaltonen, Caroline Jansson, Daniel Bexell, Ninib Baryawno, David Gisselsson, Catharina Hagerling
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTDespite aggressive treatment, the 5-year event-free survival rate for children with high-risk neuroblastoma is
Externí odkaz:
https://doaj.org/article/b026693053e149a8a14c87e0554ab387
Autor:
Emma Fransson, Emilia Gottberg, Rodrigo Munoz Mitev, David Gisselsson, Kristine Hagelsteen, Louise Tofft, Pernilla Stenström, Christina Granéli
Publikováno v:
BMC Pediatrics, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Optimizing rectal suction biopsy (RSB) diagnostics in Hirschsprung’s disease (HD) may shorten diagnostic time and prevent need for repeated biopsies. Aim To explore whether systematic orientation of fresh RSB specimens increased
Externí odkaz:
https://doaj.org/article/25a6a0992b3c4577bcd7986b095a1a1a
Autor:
Christina Graneli, Sofia Patarroyo, Rodrigo Munoz Mitev, David Gisselsson, Emilia Gottberg, Tobias Erlöv, Tomas Jansson, Kristine Hagelsteen, Magnus Cinthio, Pernilla Stenström
Publikováno v:
BMC Pediatrics, Vol 22, Iss 1, Pp 1-10 (2022)
Highlights • To confirm ganglionic bowel wall in Hirschsprung’s disease, intra-operative frozen biopsy samples are required. This means a prolonged anesthesia time and a more immediate diagnostic method is warranted. • Muscle layers’ thicknes
Externí odkaz:
https://doaj.org/article/59b715dd735b4a92a2e7a16a3fd61f18
Autor:
Anders Edsjö, Anna Lindstrand, David Gisselsson, Paula Mölling, Mikaela Friedman, Lucia Cavelier, Maria Johansson, Hans Ehrencrona, Therese Fagerqvist, Tobias Strid, Lovisa Lovmar, Bo Jacobsson, Åsa Johansson, Lars Engstrand, Craig E. Wheelock, Per Sikora, Valtteri Wirta, Thoas Fioretos, Richard Rosenquist
Publikováno v:
Cambridge Prisms: Precision Medicine, Vol 1 (2023)
Precision medicine has the potential to transform healthcare by moving from one-size-fits-all to personalised treatment and care. This transition has been greatly facilitated through new high-throughput sequencing technologies that can provide the un
Externí odkaz:
https://doaj.org/article/3d12b170a0d245a39c48e76429fb9954
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Natalie Andersson et al. present DEVOLUTION, an algorithm and tool that allows researchers to reconstruct tumor clonal lineages from copy number and/or sequencing data. They validate this method on a diverse cohort of pediatric cancers, demonstrating
Externí odkaz:
https://doaj.org/article/46257a5e4a4247b2ac64a03a2839e78b
Autor:
Sofie Olsson Hau, Alexandra Petersson, Björn Nodin, Emelie Karnevi, Karolina Boman, Caroline Williamsson, Jakob Eberhard, Karin Leandersson, David Gisselsson, Margareta Heby, Karin Jirström
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-7 (2020)
Abstract Background Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic cancer is still often
Externí odkaz:
https://doaj.org/article/65213e2c01724b3fbb80964c6bbfe03c
Autor:
Carl Sandén, Henrik Lilljebjörn, Christina Orsmark Pietras, Rasmus Henningsson, Karim H. Saba, Niklas Landberg, Hanna Thorsson, Sofia von Palffy, Pablo Peña-Martinez, Carl Högberg, Marianne Rissler, David Gisselsson, Vladimir Lazarevic, Gunnar Juliusson, Helena Ågerstam, Thoas Fioretos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid
Externí odkaz:
https://doaj.org/article/e35f9025834f4b02be68bf3c32279eaa
Autor:
Anders Valind, David Gisselsson
Publikováno v:
Cancer Reports, Vol 4, Iss 6, Pp n/a-n/a (2021)
Abstract Background Therapeutic activation of tumor‐infiltrating lymphocytes using monoclonal antibodies targeting PD1 or PD‐L1 (immune checkpoint inhibitors—ICIs) has revolutionized treatment of specific solid tumors in adult cancer patients,
Externí odkaz:
https://doaj.org/article/3796268254cb4b70835014dc14b33527
Autor:
Katarzyna Radke, Karin Hansson, Jonas Sjölund, Magdalena Wolska, Jenny Karlsson, Javanshir Esfandyari, Kristian Pietras, Kristina Aaltonen, David Gisselsson, Daniel Bexell
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101149- (2021)
High-risk neuroblastoma has a poor prognosis despite intense treatment, demonstrating the need for new therapeutic strategies. Here we evaluated the effects of rigosertib (ON-01910.Na) in preclinical models of high-risk neuroblastoma. Among several h
Externí odkaz:
https://doaj.org/article/6744e2c17bf2479da962240e572b1b78