Zobrazeno 1 - 10
of 69
pro vyhledávání: '"David, Falck"'
Autor:
Monika Svecla, Annalisa Moregola, Lorenzo Da Dalt, Jasmine Nour, Andrea Baragetti, Patrizia Uboldi, Alessandra Idini, Manfred Wuhrer, Giangiacomo Beretta, David Falck, Fabrizia Bonacina, Giuseppe Danilo Norata
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Abstract The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-acetylgalactosamine (Ga
Externí odkaz:
https://doaj.org/article/22aa1926ab7d4d789f5776e7cae7fd1e
Autor:
Steven W. de Taeye, Angela I. Schriek, Jeffrey C. Umotoy, Marloes Grobben, Judith A. Burger, Rogier W. Sanders, Gestur Vidarsson, Manfred Wuhrer, David Falck, Neeltje A. Kootstra, Marit J. van Gils
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have the capacity to delay viral rebound when administered to people with HIV-1 (PWH) during anti-retroviral therapy (ART) interruption. To further enhan
Externí odkaz:
https://doaj.org/article/bd55cd58e2634a59b51fc88dc6c76b5f
Autor:
Daniel P. Potaczek, Bianca D. M. van Tol, David Falck, Christina Krolczik, Kristina Zlatina, Wilhelm Bertrams, Jochen Wilhelm, Bernd Schmeck, Benjamin Seeliger, Sascha David, Chrysanthi Skevaki, Elisabeth Mack, Werner Seeger, Liliana Schaefer, Sebastian P. Galuska, Manfred Wuhrer, Małgorzata Wygrecka
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Thromboembolic complications are common in severe COVID-19 and are thought to result from excessive neutrophil-extracellular-trap (NET)-driven immunothrombosis. Glycosylation plays a vital role in the efficiency of immunoglobulin A (IgA) effector fun
Externí odkaz:
https://doaj.org/article/ae3bec5ce3e84666815611c2e161c0fc
Autor:
Christoph Gstöttner, Steffen Lippold, Michaela Hook, Feng Yang, Markus Haberger, Manfred Wuhrer, David Falck, Tilman Schlothauer, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The antibody- FcγRIIIa interaction triggers key immunological responses such as antibody dependent cellular cytotoxicity (ADCC), making it highly important for therapeutic mAbs. Due to the direct glycan-glycan interaction with FcγRIIIa receptor, di
Externí odkaz:
https://doaj.org/article/17823215efd24dc59d0603caae56befe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmunoglobulin G (IgG) contains a conserved N-glycan in the fragment crystallizable (Fc), modulating its structure and effector functions. In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) alterations of IgG Fc-gl
Externí odkaz:
https://doaj.org/article/bac6bdbd6bbd4472a110c6ef734320f7
Autor:
Róisín O’Flaherty, Manuela Amez Martín, Richard A. Gardner, Patrick M. Jennings, Pauline M. Rudd, Daniel I. R. Spencer, David Falck
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 125 (2024)
Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. EPO N-glycosylation influences important pharmacological parameters, pr
Externí odkaz:
https://doaj.org/article/7761628facb24ab8a1a57ca707d15dcd
Autor:
Iwona Wojcik, David E. Schmidt, Lisa A. de Neef, Minke A. E. Rab, Bob Meek, Okke de Weerdt, Manfred Wuhrer, C. Ellen van der Schoot, Jaap J. Zwaginga, Masja de Haas, David Falck, Gestur Vidarsson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract As a lymphoid organ, the spleen hosts a wide range of immune cell populations, which not only remove blood-borne antigens, but also generate and regulate antigen-specific immune responses. In particular, the splenic microenvironment has been
Externí odkaz:
https://doaj.org/article/be3e529ee6ca40edb4e9c9d2fe655c33
Autor:
David Falck, Martin Lechmann, Ana Momčilović, Marco Thomann, Carolien A. M. Koeleman, Cordula Jany, Sebastian Malik, Manfred Wuhrer, Dietmar Reusch
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, whic
Externí odkaz:
https://doaj.org/article/968dcd0ed8d74a8d99c692168604e66f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b8689c4c6d90448f8e050b27a1073d6d
Autor:
Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Immunoglobulin A (IgA) has two subclasses, IgA1 and IgA2, but differential effects on inflammation are unclear. Here the authors show that IgA2, when compared with IgA1, has stronger pro-inflammatory functions associated with changed glycosylation an
Externí odkaz:
https://doaj.org/article/10d5aea8f2dd4168b05d11de004c1d68