Zobrazeno 1 - 10
of 54
pro vyhledávání: '"David, Dunger"'
Autor:
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo, Pieter Gillard, Kristina Casteels, Lutgart Overbergh, Chris Wallace, Mark Evans, Ajay Thankamony, Emile Hendriks, Loredana Marcoveccchio, Timothy Tree, Noel G. Morgan, Sarah Richardson, John A. Todd, Linda Wicker, Adrian Mander, Colin Dayan, Mohammad Alhadj Ali, Thomas Pieber, Decio L. Eizirik, Myriam Cnop, Flemming Pociot, Jesper Johannesen, Peter Rossing, Cristina Legido Quigley, Roberto Mallone, Raphael Scharfmann, Christian Boitard, Timo Otonkoski, Riitta Veijola, Matej Oresic, Jorma Toppari, Thomas Danne, Anette G. Ziegler, Peter Achenbach, Teresa Rodriguez-Calvo, Michele Solimena, Ezio E. Bonifacio, Stephan Speier, Reinhard Holl, Francesco Dotta, Francesco Chiarelli, Piero Marchetti, Emanuele Bosi, Stefano Cianfarani, Paolo Ciampalini, Carine De Beaufort, Knut Dahl-Jørgensen, Torild Skrivarhaug, Geir Joner, Lars Krogvold, Przemka Jarosz-Chobot, Tadej Battelino, Bernard Thorens, Martin Gotthardt, Bart O. Roep, Tanja Nikolic, Arnaud Zaldumbide, Ake Lernmark, Marcus Lundgren, Guillaume Costacalde, Thorsten Strube, Almut Nitsche, Jose Vela, Matthias Von Herrath, Johnna Wesley, Antonella Napolitano-Rosen, Melissa Thomas, Nanette Schloot, Allison Goldfine, Frank Waldron-Lynch, Jill Kompa, Aruna Vedala, Nicole Hartmann, Gwenaelle Nicolas, Jean van Rampelbergh, Nicolas Bovy, Sanjoy Dutta, Jeannette Soderberg, Simi Ahmed, Frank Martin, Esther Latres, Gina Agiostratidou, Anne Koralova, Ruben Willemsen, Anne Smith, Binu Anand, Vipan Datta, Vijith Puthi, Sagen Zac-Varghese, Renuka Dias, Premkumar Sundaram, Bijay Vaidya, Catherine Patterson, Katharine Owen, Barbara Piel, Simon Heller, Tabitha Randell, Tasso Gazis, Elise Bismuth Reismen, Jean-Claude Carel, Jean-Pierre Riveline, Jean-Francoise Gautier, Fabrizion Andreelli, Florence Travert, Emmanuel Cosson, Alfred Penfornis, Catherine Petit, Bruno Feve, Nadine Lucidarme, Jean-Paul Beressi, Catherina Ajzenman, Alina Radu, Stephanie Greteau-Hamoumou, Cecile Bibal, Thomas Meissner, Bettina Heidtmann, Sonia Toni, Birgit Rami-Merhar, Bart Eeckhout, Bernard Peene, N. Vantongerloo, Toon Maes, Leen Gommers
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104625- (2023)
Summary: Background: Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed to identify transcriptional changes associated with the disease progress
Externí odkaz:
https://doaj.org/article/2c41bdea112542e1901b5cf0742fc2e4
Autor:
Kathryn Beardsall, Lynn Thomson, Catherine Guy, Simon Bond, Annabel Allison, Beatrice Pantaleo, Stavros Petrou, Sungwook Kim, David Dunger, Roman Hovorka
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 8, Iss 16 (2021)
Background: Hyperglycaemia and hypoglycaemia are common in preterm infants and are associated with increased mortality and morbidity. Continuous glucose monitoring is widely used to target glucose control in adults and children, but not in neonates.
Externí odkaz:
https://doaj.org/article/5b91c45f253349f48407127b4a5ae7dc
Autor:
Sandra Horsch, Alessandro Parodi, Boubou Hallberg, Mariya Malova, Isabella M. Björkman-Burtscher, Ingrid Hansen-Pupp, Neil Marlow, Kathryn Beardsall, David Dunger, Mirjam van Weissenbruch, Lois E. H. Smith, Mohamed Hamdani, Alexandra Mangili, Norman Barton, Luca A. Ramenghi, Ann Hellström, David Ley, ROPP-2008-01 Study Team
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Background: Postnatal insulin-like growth factor-1 (IGF-1) replacement with recombinant human (rh)IGF-1 and IGF binding protein-3 (rhIGF-1/rhIGFBP-3) is being studied as a potential treatment to reduce comorbidities of prematurity. We have recently r
Externí odkaz:
https://doaj.org/article/4c47f74bcd024965bb4acccc525a64da
Autor:
Fiona Campbell, John Todd, Tabitha Randell, Daniela Elleri, Gianluca Musolino, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Martin Tauschmann, Charlotte Boughton, Nicola Trevelyan, Carlo L Acerini, Korey Hood, Craig Kollman, Judy Sibayan, Roman Hovorka, Professor David Dunger, Atrayee Ghatak, Rachel Besser, Elizabeth Northam, Eleanor Scott, Julia Lawton, Stephane Roze, Nate Cohen
Publikováno v:
BMJ Open, Vol 10, Iss 3 (2020)
IntroductionManagement of newly diagnosed type 1 diabetes (T1D) in children and adolescents is challenging for patients, families and healthcare professionals. The objective of this study is to determine whether continued intensive metabolic control
Externí odkaz:
https://doaj.org/article/b051c1ecba6d43e7bf3e8c14aeefc55a
Autor:
Charlotte S Wilhelm-Benartzi, Sarah E Miller, Sylvaine Bruggraber, Diane Picton, Mark Wilson, Katrina Gatley, Anita Chhabra, M Loredana Marcovecchio, A Emile J Hendriks, Hilde Morobé, Piotr Jaroslaw Chmura, Simon Bond, Bärbel Aschemeier-Fuchs, Mikael Knip, Timothy Tree, Lut Overbergh, Jaivier Pall, Olivier Arnaud, Michael J Haller, Almut Nitsche, Anke M Schulte, Chantal Mathieu, Adrian Mander, David Dunger
Publikováno v:
BMJ Open
Wilhelm-Benartzi, C S, Miller, S E, Bruggraber, S, Picton, D, Wilson, M, Gatley, K, Chhabra, A, Marcovecchio, M L, Hendriks, A E J, Morobé, H, Chmura, P J, Bond, S, Aschemeier-Fuchs, B, Knip, M, Tree, T, Overbergh, L, Pall, J, Arnaud, O, Haller, M J, Nitsche, A, Schulte, A M, Mathieu, C, Mander, A & Dunger, D 2021, ' Study protocol Minimum effective low dose: Anti-human thymocyte globulin (MELD-ATG) : Phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes ', BMJ Open, vol. 11, no. 12, e053669 . https://doi.org/10.1136/bmjopen-2021-053669
BMJ OPen
Wilhelm-Benartzi, C S, Miller, S E, Bruggraber, S, Picton, D, Wilson, M, Gatley, K, Chhabra, A, Marcovecchio, M L, Hendriks, A E J, Morobé, H, Chmura, P J, Bond, S, Aschemeier-Fuchs, B, Knip, M, Tree, T, Overbergh, L, Pall, J, Arnaud, O, Haller, M J, Nitsche, A, Schulte, A M, Mathieu, C, Mander, A & Dunger, D 2021, ' Study protocol Minimum effective low dose: Anti-human thymocyte globulin (MELD-ATG) : Phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes ', BMJ Open, vol. 11, no. 12, e053669 . https://doi.org/10.1136/bmjopen-2021-053669
BMJ OPen
• Introduction: Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin-producing β cells of the pancreas. One immunosuppressive agent that has recently shown promise in the treatment of new-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0f7f45d778801769d91a723bd536ad
Autor:
Andrew J Farmer, Richard Stevens, Jennifer Hirst, Tom Lung, Jason Oke, Philip Clarke, Paul Glasziou, Andrew Neil, David Dunger, Helen M Colhoun, Christopher Pugh, Germain Wong, Rafael Perera, Brian Shine
Publikováno v:
Health Technology Assessment, Vol 18, Iss 14 (2014)
Background: Annual screening for adults with type 2 diabetes to detect the early onset of kidney disease is widely recommended, but the recommendations are based on a limited methodological approach. In addition, there are continuing uncertainties ab
Externí odkaz:
https://doaj.org/article/01248ec0344c435e929615b988edd401
Autor:
Mark Caulfield, Solbritt Rantapää Dahlqvist, Eleftheria Zeggini, Michael Weedon, Paul Martin, Elaine Dennison, Patricia Munroe, Detelina Grozeva, John Isaacs, Stephen Eyre, Alex MacGregor, Kate Duffus, Andrew Hattersley, DOROTHEE DIOGO, Luis Rodriguez-Rodriguez, Steven Young-Min, Chris Wallace, Miguel Gonzalez-Gay, Tom Huizinga, Stephen Newhouse, Alexandra Zhernakova, Melanie Newport, Deborah Symmons, Lisa Jones, Michael O'Donovan, Wan-Fai Ng, Nadira Yusupovna Yuldasheva, Cyrus Cooper, Willem Ouwehand, Philip Conaghan, Gerome Breen, Lars Alfredsson, Karim Raza, Hana Lango Allen, Jane Worthington, Mark Iles, Ann Morgan, Professor David Dunger, Soumya Raychaudhuri, Panos Deloukas, Marwan Bukhari, Alastair Forbes, Allan Young, Lars Klareskog, Leonid Padyukov, Fraser Birrell, Charlie Lees, Anne Barton, Martin Tobin, Patrick Concannon, Jon Packham, Natalie Prescott, Javier Martin, Kimme Hyrich, Lude Franke, John Bowes, Ian Bruce, Chiea Chuen Khor, Stephen Rich, Miles Parkes, Sarah Hunt, Tim Bishop, Gosia Trynka, Richard Dobson, Anna Dominiczak, Cisca Wijmenga, Mark McCarthy, Cecilia Lindgren, Rene Toes, Alistair Hall
Publikováno v:
Nature Genetics, 44(12), 1336-1340. Nature Publishing Group
Nature Genetics, 44(12), 1336-1340
Nature genetics
Nature Genetics, 44(12), 1336-1340
Nature genetics
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European ancestry and 15,870 con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65582d467a3a6efd2d9d56dc4e9b5ee
Autor:
Natalie R. van Zuydam, Alexander Stiby, Moustafa Abdalla, Erin Austin, Emma H. Dahlström, Stela McLachlan, Efthymia Vlachopoulou, Emma Ahlqvist, Chen Di Liao, Niina Sandholm, Carol Forsblom, Anubha Mahajan, Neil R. Robertson, N. William Rayner, Eero Lindholm, Juha Sinisalo, Markus Perola, Milla Kallio, Emily Weiss, Jackie Price, Andrew Paterson, Barbara Klein, Veikko Salomaa, Colin N.A. Palmer, Per-Henrik Groop, Leif Groop, Mark I. McCarthy, Mariza de Andrade, Andrew P. Morris, Jemma C. Hopewell, Helen M. Colhoun, Iftikhar J. Kullo, Sólveig Grétarsdóttir, Guðmar Þorleifsson, Unnur þorsteinsdóttir, Kari Stefansson, Michael Mark, Timo Kanninen, Barbara Thorand, Giuseppe Remuzzi, David Dunger, Angela Shore, Ulf Smith, Seppo Ylä-Herttuala, Claudio Cobelli, Riccardo Bellazzi, Ele Ferrannini, Carlo Patrono, Pirjo Nuutila, Paul McKeague, Birgit Steckel-Hamann, Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan
Publikováno v:
Circulation. Genomic and Precision Medicine
Van Zuydam, N R, Stiby, A, Abdalla, M, Dahlstrom, EH, McLachlan, S, Vlachopoulou, E, Price, J F, Ahlqvist, E, Di Liao, C, Sandholm, N, Forsblom, C, Mahajan, A, Robertson, N R, Rayner, N W, Lindholm, E, Sinisalo, J, Perola, M, Kallio, M, Weiss, E, Paterson, A, Klein, B, Salomaa, V, McCarthy, M, de Andrade, M, Morris, AP, Hopewell, JC, Colhoun, H M & Kullo, IJ 2021, ' A genome-wide association study of peripheral artery disease ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.119.002862
Circ. Genom. Precis. Med. 14:e002862 (2021)
Circulation: Genomic and Precision Medicine
Van Zuydam, N R, Stiby, A, Abdalla, M, Dahlstrom, EH, McLachlan, S, Vlachopoulou, E, Price, J F, Ahlqvist, E, Di Liao, C, Sandholm, N, Forsblom, C, Mahajan, A, Robertson, N R, Rayner, N W, Lindholm, E, Sinisalo, J, Perola, M, Kallio, M, Weiss, E, Paterson, A, Klein, B, Salomaa, V, McCarthy, M, de Andrade, M, Morris, AP, Hopewell, JC, Colhoun, H M & Kullo, IJ 2021, ' A genome-wide association study of peripheral artery disease ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.119.002862
Circ. Genom. Precis. Med. 14:e002862 (2021)
Circulation: Genomic and Precision Medicine
Supplemental Digital Content is available in the text.
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1331a7c40e7d9286577d43c5d5fbb16a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458405
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458405
Autor:
Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N. William Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel, Marcus E. Kleber, Christopher P. Nelson, Lydia Coulter Kwee, Tõnu Esko, Evelin Mihailov, Reedik Mägi, Lili Milani, Krista Fischer, Stavroula Kanoni, Jitender Kumar, Ci Song, Jaana A. Hartiala, Nancy L. Pedersen, Markus Perola, Christian Gieger, Annette Peters, Liming Qu, Sara M. Willems, Alex S.F. Doney, Andrew D. Morris, Yan Zheng, Giorgio Sesti, Frank B. Hu, Lu Qi, Markku Laakso, Unnur Thorsteinsdottir, Harald Grallert, Cornelia van Duijn, Muredach P. Reilly, Erik Ingelsson, Panos Deloukas, Sek Kathiresan, Andres Metspalu, Svati H. Shah, Juha Sinisalo, Veikko Salomaa, Anders Hamsten, Nilesh J. Samani, Winfried März, Stanley L. Hazen, Hugh Watkins, Danish Saleheen, Andrew P. Morris, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, Colin N.A. Palmer, John Danesh, Jeanette Erdmann, Dongfeng Gu, Jaspal S. Kooner, Robert Roberts, Heribert Schunkert, Themistocles L. Assimes, Stefan Blankenberg, Bernhard O. Boehm, John C. Chambers, Robert Clarke, Rory Collins, George Dedoussis, Paul W. Franks, G. Kees Hovingh, Bong-Jo Kim, Terho Lehtimäki, Ruth McPherson, Markku S Nieminen, Christopher O’Donnell, Samuli Ripatti, Manjinder S Sandhu, Stefan Schreiber, Agneta Siegbahn, Cristen J. Willer, Pierre A. Zalloua, Michael Mark, Timo Kanninen, Barbara Thorand, Giuseppe Remuzzi, David Dunger, Angela Shore, Ulf Smith, Per-Henrik Groop, Seppo Ylä-Herttuala, Claudio Cobelli, Riccardo Bellazzi, Ele Ferrannini, Carlo Patrono, Pirjo Nuutila, Paul McKeague, Birgit Steckel-Hamann, Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan
Publikováno v:
Circ. Genom. Precis. Med. 13, 640-648 (2020)
Van Zuydam, N R, Ladenvall, C, Voight, B F, Strawbridge, R J, Fernandez-tajes, J, Rayner, N W, Robertson, N R, Mahajan, A, Vlachopoulou, E, Goel, A, Kleber, M E, Nelson, C P, Kwee, L C, Esko, T, Mihailov, E, Mägi, R, Milani, L, Fischer, K, Kanoni, S, Kumar, J, Song, C, Hartiala, J A, Pedersen, N L, Perola, M, Gieger, C, Peters, A, Qu, L, Willems, S M, Doney, A S F, Morris, A P, Zheng, Y, Sesti, G, Hu, F B, Qi, L, Laakso, M, Thorsteinsdottir, U, Grallert, H, Van Duijn, C, Reilly, M P, Ingelsson, E, Deloukas, P, Kathiresan, S, Metspalu, A, Shah, S H, Sinisalo, J, Salomaa, V, Hamsten, A, Samani, N J, März, W, Hazen, S L, Watkins, H, Saleheen, D, Morris, A P, Colhoun, H M, Groop, L, Mccarthy, M I, Palmer, C N A, Danesh, J, Erdmann, J, Gu, D, Kooner, J S, Roberts, R, Schunkert, H, Assimes, T L, Blankenberg, S, Boehm, B O, Chambers, J C, Clarke, R, Collins, R, Dedoussis, G, Franks, P W, Hovingh, G K, Kim, B, Lehtimäki, T, Mcpherson, R, Nieminen, M S, O’donnell, C, Ripatti, S, Sandhu, M S, Schreiber, S, Siegbahn, A, Willer, C J, Zalloua, P A, Mark, M, Kanninen, T, Thorand, B, Remuzzi, G, Dunger, D, Shore, A, Smith, U, Groop, P, Ylä-herttuala, S, Cobelli, C, Bellazzi, R, Ferrannini, E, Patrono, C, Nuutila, P, Mckeague, P, Steckel-hamann, B, Gan, L, Nogoceke, E, Tortoli, P, Jablonka, B & Brosnan, M 2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and precision medicine, vol. 13, no. 6 . https://doi.org/10.1161/CIRCGEN.119.002769
2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and Precision Medicine, vol. 13, no. 6, pp. e002769 . https://doi.org/10.1161/CIRCGEN.119.002769
Circulation. Genomic and Precision Medicine
Circulation-Genomic and Precision Medicine, 13(6), 640-648. Lippincott Williams & Wilkins
Van Zuydam, N R, Ladenvall, C, Voight, B F, Strawbridge, R J, Fernandez-tajes, J, Rayner, N W, Robertson, N R, Mahajan, A, Vlachopoulou, E, Goel, A, Kleber, M E, Nelson, C P, Kwee, L C, Esko, T, Mihailov, E, Mägi, R, Milani, L, Fischer, K, Kanoni, S, Kumar, J, Song, C, Hartiala, J A, Pedersen, N L, Perola, M, Gieger, C, Peters, A, Qu, L, Willems, S M, Doney, A S F, Morris, A P, Zheng, Y, Sesti, G, Hu, F B, Qi, L, Laakso, M, Thorsteinsdottir, U, Grallert, H, Van Duijn, C, Reilly, M P, Ingelsson, E, Deloukas, P, Kathiresan, S, Metspalu, A, Shah, S H, Sinisalo, J, Salomaa, V, Hamsten, A, Samani, N J, März, W, Hazen, S L, Watkins, H, Saleheen, D, Morris, A P, Colhoun, H M, Groop, L, Mccarthy, M I, Palmer, C N A, Danesh, J, Erdmann, J, Gu, D, Kooner, J S, Roberts, R, Schunkert, H, Assimes, T L, Blankenberg, S, Boehm, B O, Chambers, J C, Clarke, R, Collins, R, Dedoussis, G, Franks, P W, Hovingh, G K, Kim, B, Lehtimäki, T, Mcpherson, R, Nieminen, M S, O’donnell, C, Ripatti, S, Sandhu, M S, Schreiber, S, Siegbahn, A, Willer, C J, Zalloua, P A, Mark, M, Kanninen, T, Thorand, B, Remuzzi, G, Dunger, D, Shore, A, Smith, U, Groop, P, Ylä-herttuala, S, Cobelli, C, Bellazzi, R, Ferrannini, E, Patrono, C, Nuutila, P, Mckeague, P, Steckel-hamann, B, Gan, L, Nogoceke, E, Tortoli, P, Jablonka, B & Brosnan, M 2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and precision medicine, vol. 13, no. 6 . https://doi.org/10.1161/CIRCGEN.119.002769
2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and Precision Medicine, vol. 13, no. 6, pp. e002769 . https://doi.org/10.1161/CIRCGEN.119.002769
Circulation. Genomic and Precision Medicine
Circulation-Genomic and Precision Medicine, 13(6), 640-648. Lippincott Williams & Wilkins
Supplemental Digital Content is available in the text.
Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk i
Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c110178bdcbf867d2320b1757655095
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60858
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60858
Autor:
Sandra, Horsch, Alessandro, Parodi, Boubou, Hallberg, Mariya, Malova, Isabella M, Björkman-Burtscher, Ingrid, Hansen-Pupp, Neil, Marlow, Kathryn, Beardsall, David, Dunger, Mirjam, van Weissenbruch, Lois E H, Smith, Mohamed, Hamdani, Alexandra, Mangili, Norman, Barton, Luca A, Ramenghi, Ann, Hellström, David, Ley
Publikováno v:
Frontiers in Pediatrics
Background: Postnatal insulin-like growth factor-1 (IGF-1) replacement with recombinant human (rh)IGF-1 and IGF binding protein-3 (rhIGF-1/rhIGFBP-3) is being studied as a potential treatment to reduce comorbidities of prematurity. We have recently r