Zobrazeno 1 - 10 of 312 pro vyhledávání: '"David, D'Cruz"'
1
Akademický článek
ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis
Autor: Stephanie Guillet, Tomi Lazarov, Natasha Jordan, Bertrand Boisson, Maria Tello, Barbara Craddock, Ting Zhou, Chihiro Nishi, Rohan Bareja, Hairu Yang, Frederic Rieux-Laucat, Rosa Irene Fregel Lorenzo, Sabrina D Dyall, David Isenberg, David D'Cruz, Nico Lachmann, Olivier Elemento, Agnes Viale, Nicholas D Socci, Laurent Abel, Shigekazu Nagata, Morgan Huse, W Todd Miller, Jean-Laurent Casanova, Frédéric Geissmann
Publikováno v: eLife, Vol 13 (2024)
Systemic lupus erythematosus (SLE) is an autoimmune disease, the pathophysiology and genetic basis of which are incompletely understood. Using a forward genetic screen in multiplex families with SLE, we identified an association between SLE and compo
Externí odkaz: https://doaj.org/article/bbeacfc654b64900aa3479d5ae42195e
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2
Akademický článek
Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue
Autor: Lucia Montorsi, Michael J. Pitcher, Yuan Zhao, Chiara Dionisi, Alicia Demonti, Thomas J. Tull, Pawan Dhami, Richard J. Ellis, Cynthia Bishop, Jeremy D. Sanderson, Sahil Jain, David D’Cruz, Deena L. Gibbons, Thomas H. Winkler, Mats Bemark, Francesca D. Ciccarelli, Jo Spencer
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Intestinal homeostasis is maintained by the response of gut-associated lymphoid tissue to bacteria transported across the follicle associated epithelium into the subepithelial dome. The initial response to antigens and how bacteria are handl
Externí odkaz: https://doaj.org/article/335f7b7096184522be8b2a65d72908f9
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4
Akademický článek
The HAVEN study—hydroxychloroquine in ANCA vasculitis evaluation—a multicentre, randomised, double-blind, placebo-controlled trial: study protocol and statistical analysis plan
Autor: Annastazia E. Learoyd, Lauren Arnold, Fiona Reid, Nicholas Beckley-Hoelscher, Alina Casian, Shirish Sangle, Neil Morton, Louise Nel, Angela Cape, Susan John, Sangmi Kim, Dharshene Shivapatham, Raashid Luqmani, David Jayne, James Galloway, Abdel Douiri, David D’Cruz, on behalf of the HAVEN study group
Publikováno v: Trials, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Patients with non-severe ANCA-associated vasculitis (AAV) are often prescribed immunosuppressive medications that are associated with severe side effects and a reduced quality of life. There is an unmet need for safer effective tr
Externí odkaz: https://doaj.org/article/25f14049fefe404ca00f3e0ce094723e
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5
Akademický článek
Safety and efficacy of belimumab in older adults with SLE: results of an integrated analysis of clinical trial data
Autor: Anne Hammer, Beulah Ji, David A Roth, David D'Cruz, Paige Meizlik, Gina Eriksson, Yulia Green
Publikováno v: Lupus Science and Medicine, Vol 10, Iss 1 (2023)
Objective Assess the safety and efficacy of belimumab in older adults with SLE.Methods This post hoc integrated analysis (GSK Study 116559) included safety data from six randomised, placebo-controlled belimumab trials (BLISS-76, BLISS-52, BLISS-SC, N
Externí odkaz: https://doaj.org/article/238a809959434cd0bbf78b08d243c9e0
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6
Akademický článek
Efficacy of belimumab in two serologically distinct high disease activity subgroups of patients with systemic lupus erythematosus: post-hoc analysis of data from the phase III programme
Autor: Toni Maslen, David D'Cruz, Mihaela Ianosev, Christel Wilkinson
Publikováno v: Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Objective To assess the appropriateness of expanded serological activity eligibility criteria for belimumab use in the UK systemic lupus erythematosus (SLE) population (and possibly other countries), which includes patients with either anti-double-st
Externí odkaz: https://doaj.org/article/2af1d521bf0847e5b8503cb1f9e80d96
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7
Early infection risk in patients with systemic lupus erythematosus treated with rituximab or belimumab from the British Isles Lupus Assessment Group Biologics Register (BILAG-BR): a prospective longitudinal study
Autor: Mia Rodziewicz, Sarah Dyball, Mark Lunt, Stephen McDonald, Emily Sutton, Ben Parker, Ian N Bruce, Rikki Abernethy, Yasmeen Ahmad, Mohamed Akil, Sarah Bartram, Mike Batley, Anurag Bharadwaj, Ian Bruce, Francesco Carlucci, Antoni Chan, Bhaskar Dasgupta, David D'Cruz, Denise De Lord, Bernard Dyke, Christopher Edwards, Nicola Erb, Adrian Farrell, Mary Gayed, Nagui Gendi, Luke Gompels, Caroline Gordon, Patrick Gordon, Bridget Griffiths, Nicola Gullick, Harsha Gunwardena, Richard Haigh, Shahir Hamdulay, Sahena Haque, David Hutchinson, David Isenberg, David Jayne, Rachel Jeffery, Deepti Kapur, Arvind Kaul, Jon King, Sally Knights, Ellie Korendowych, Peter Lanyon, Madhu Mahindrakar, Jonathan Marks, Liza McCann, Zoe McLaren, Rapti Mediwake, Ajit Menon, Devesh Mewar, Steven Young Min, Jagdish Nair, Edmond O'Riordan, Dev Pyne, Fouz Rahmeh, Marian Regan, John Reynolds, Ben Rhodes, Ceril Rhys-Dillon, Joanna C Robson, Shireen Shaffu, T Sheeran, Sarah Skeoch, Bhrigu Raj Sood, Richard Stratton, Lee-Suan Teh, Erin Vermaak, Ed Vital, Rosemary Waller, Richard Watts, Jananath Wijeyekoon, Chee-Seng Yee, Cee Yi Yong, Hazem Youssef, Abid Yusuf, Asad Zoma
Publikováno v: The Lancet Rheumatology. 5:e284-e292
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd5cb8409d61eaf4c0d625afe06911fd
https://doi.org/10.1016/s2665-9913(23)00091-7
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8
Akademický článek
Respiratory subtype of relapsing polychondritis frequently presents as difficult asthma: a descriptive study of respiratory involvement in relapsing polychondritis with 13 patients from a single UK centre
Autor: Shirish Dubey, Colin Gelder, Grace Pink, Asad Ali, Christopher Taylor, Joanna Shakespeare, Susan Townsend, Patrick Murphy, Nicholas Hart, David D'Cruz
Publikováno v: ERJ Open Research, Vol 7, Iss 1 (2021)
Introduction Relapsing polychondritis is a rare multisystem vasculitis characterised by recurrent cartilage inflammation. Respiratory involvement, of which tracheobronchomalacia (TBM) is the commonest form, is difficult to treat and is linked to incr
Externí odkaz: https://doaj.org/article/0eef63a271b144b5b212014110b659d8
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