Výsledky vyhledávání - "David, Coelho"

Akademický článek

Confocal laser scanning microscopy reveals species-specific differences in distribution of fluorescent proteins in coral tissues

Autor: Giulia M. Marchioro, David Coelho, Thibault Bouderlique, Daniel Abed-Navandi, Michael Schagerl, Cecilia D’Angelo, Luise Kruckenhauser, Igor Adameyko, Pedro R. Frade

Publikováno v: Frontiers in Marine Science, Vol 11 (2024)

Reef-building corals have a variety of green fluorescent protein (GFP)-like proteins, also known as fluorescent proteins (FPs). These proteins have broad spectral properties covering most of the visible spectrum, with fluorophores fluorescing from cy

Externí odkaz: https://doaj.org/article/ef8d49e28c63402da4f1419437934eef

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Akademický článek

Check-Bit Region Exploration in Two-Dimensional Error Correction Codes

Autor: David Freitas, David Mota, David Coelho, Humberto Fontinele, Alexandre Coelho, Jarbas Silveira, Lirida Naviner, Joao Mota, Cesar Marcon

Publikováno v: IEEE Access, Vol 12, Pp 131830-131841 (2024)

The diversity of nanosatellite applications is increasingly attracting the scientific community’s attention. The main component of these satellites is the OnBoard Computer (OBC), which is responsible for all control and processing. Also, OBC encomp

Externí odkaz: https://doaj.org/article/84a0cbb491fe4fa884a21aa86d19abca

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Akademický článek

A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism

Autor: Karim Matmat, Jean-Baptiste Conart, Paul-Henri Graindorge, Sandra El Kouche, Ziad Hassan, Youssef Siblini, Rémy Umoret, Ramia Safar, Okan Baspinar, Aurélie Robert, Jean-Marc Alberto, Abderrahim Oussalah, David Coelho, Jean-Louis Guéant, Rosa-Maria Guéant-Rodriguez

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)

Abstract Background MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a significant importance in generating S-adenosylmethionine (SAM) and S-ade

Externí odkaz: https://doaj.org/article/5befbbb86cbf45bca915fe1435c9c244

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Akademický článek

Multiomic analysis in fibroblasts of patients with inborn errors of cobalmin metabolism reveals concordance with clinical and metabolic variabilityResearch in context

Publikováno v: EBioMedicine, Vol 99, Iss , Pp 104911- (2024)

Summary: Background: The high variability in clinical and metabolic presentations of inborn errors of cobalamin (cbl) metabolism (IECM), such as the cblC/epicblC types with combined deficits in methylmalonyl-coA mutase (MUT) and methionine synthase (

Externí odkaz: https://doaj.org/article/2d3ab102cea844078b893c2d92774c33

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Akademický článek

Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency

Autor: Ziad Hassan, David Coelho, Carine Bossenmeyer-Pourié, Karim Matmat, Carole Arnold, Aurélie Savladori, Jean-Marc Alberto, Rémy Umoret, Jean-Louis Guéant, Grégory Pourié

Publikováno v: Cells, Vol 12, Iss 9, p 1267 (2023)

Impairment of one-carbon metabolism during pregnancy, either due to nutritional deficiencies in B9 or B12 vitamins or caused by specific genetic defects, is often associated with neurological defects, including cognitive dysfunction that persists eve

Externí odkaz: https://doaj.org/article/4238e1b136d94a18b1cbbbcb39e748e3

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Akademický článek

A PRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Inborn errors of vitamin B12 metabolism of the cblC class are caused by mutations in the MMACHC gene. Here, Guéant et al. report epi-cblC, a class of cblC in which patients are compound heterozygous for a genetic mutation and a secondary epimutation

Externí odkaz: https://doaj.org/article/cbd6be2fd8e245cb84a21aa02a029651

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Akademický článek

Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey[S]

Publikováno v: Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)

SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the exp

Externí odkaz: https://doaj.org/article/bd0a1abbb701431196775362cf9f8457

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Utilização do índice cefálico horizontal na estimativa do sexo e idade em crânios secos de adultos

Autor: Sara Araújo De Morais, Eduarda Feitosa Pita Lucena Viana, João Antônio Gonçalves Filho, Sofia Feitosa Nogueira Sobreira, David Coelho Amaro, João Filipe Soares Sampaio, Erasmo De Almeida Jr, Luís Carlos Cavalcante Galvão

Publikováno v: STUDIES IN HEALTH SCIENCES. 3:381-392

Introdução - A Odontologia Legal tem grande importância no processo de identificação, principalmente quando os profissionais da área recebem para análise apenas a porção cefálica do corpo. O objetivo deste estudo é verificar o dimorfismo s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b147beeb1953280bf8de181ef87d8ad
https://doi.org/10.54022/shsv3n1-034

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Epimutation in inherited metabolic disorders: the influence of aberrant transcription in adjacent genes

Autor: Jean-Louis Guéant, Youssef Siblini, Céline Chéry, Guillaume Schmitt, Rosa-Maria Guéant-Rodriguez, David Coelho, David Watkins, David S. Rosenblatt, Abderrahim Oussalah

Publikováno v: Human Genetics. 141:1309-1325

Epigenetic diseases can be produced by a stable alteration, called an epimutation, in DNA methylation, in which epigenome alterations are directly involved in the underlying molecular mechanisms of the disease. This review focuses on the epigenetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be63af2af9b40b746ab1c272782cf0ba
https://doi.org/10.1007/s00439-021-02414-9

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