NMDA receptor modulation of glutamate release in activated neutrophilsResearch in context

Autor: Ana Gutierrez del Arroyo, Anna Hadjihambi, Jenifer Sanchez, Egor Turovsky, Vitaly Kasymov, David Cain, Tom D. Nightingale, Simon Lambden, Seth G.N. Grant, Alexander V. Gourine, Gareth L. Ackland

Publikováno v: EBioMedicine, Vol 47, Iss , Pp 457-469 (2019)

Background: Neutrophil depletion improves neurologic outcomes in experimental sepsis/brain injury. We hypothesized that neutrophils may exacerbate neuronal injury through the release of neurotoxic quantities of the neurotransmitter glutamate. Methods

Externí odkaz: https://doaj.org/article/0aaa2e17d6344966b236b4d45e768b8f

Phospholipase activity of Acyloxyacyl Hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis

Autor: Randeep Singh, Yi‐Ling Chen, Soo Weei Ng, David Cain, Rachel Etherington, Clare Hardman, Graham Ogg

Psoriasis is a chronic inflammatory skin disease characterised by T helper 17 responses. Recent evidence has identified Langerhans cells as having a key role in disease pathogenesis, with constitutive high expression of CD1a and capacity to present l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae2972290e52b54d4d2a6df3903a179
https://ora.ox.ac.uk/objects/uuid:f291e48a-2966-4c8a-b413-b86a73135f4b

Cardiopulmonary Exercise Capacity and Preoperative Markers of Inflammation

Autor: Pervez Sultan, Mark R. Edwards, Ana Gutierrez del Arroyo, David Cain, J. Robert Sneyd, Richard Struthers, Gary Minto, Gareth L. Ackland

Publikováno v: Mediators of Inflammation, Vol 2014 (2014)

Explanatory mechanisms for the association between poor exercise capacity and infections following surgery are underexplored. We hypothesized that aerobic fitness—assessed by cardiopulmonary exercise testing (CPET)—would be associated with circul

Externí odkaz: https://doaj.org/article/27122d0a825e46f08a5fe455c32c2916

Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning

Autor: David Cain, Milady R. Niñonuevo, Jordan J Baker, Dana McDaniel, Yuting Huang, Judith Zhu-Shimoni, Hongbin Liu, Paula Lee Tao, Charlene Li

Publikováno v: Analytical Chemistry. 91:965-976

Bispecific antibodies are regarded as the next generation of therapeutic modalities as they can simultaneously bind multiple targets, increasing the efficacy of treatments for several diseases and opening up previously unattainable treatment designs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3510a0a81863367542f847a72077362
https://doi.org/10.1021/acs.analchem.8b04071

NMDA receptor modulation of glutamate release in activated neutrophils

Autor: David Cain, Ana Gutierrez del Arroyo, Egor A. Turovsky, Simon Lambden, Seth G. N. Grant, Vitaly Kasymov, Gareth L. Ackland, Jenifer Sanchez, Alexander V. Gourine, Thomas D. Nightingale, Anna Hadjihambi

Publikováno v: Del Arroyo, A G, Hadjihambi, A, Sanchez, J, Turovsky, E, Kasymov, V, Cain, D, Nightingale, T D, Lambden, S, Grant, S G N, Gourine, A V & Ackland, G L 2019, ' NMDA receptor modulation of glutamate release in activated neutrophils ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2019.08.004
EBioMedicine

Background Neutrophil depletion improves neurologic outcomes in experimental sepsis/brain injury. We hypothesized that neutrophils may exacerbate neuronal injury through the release of neurotoxic quantities of the neurotransmitter glutamate. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4343b27a61c7eaf049f199e8007d133
https://www.pure.ed.ac.uk/ws/files/108298253/1_s2.0_S2352396419305201_main.pdf