Výsledky vyhledávání - "David, Busse"

Akademický článek

Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study

Autor: Jörn Grensemann, David Busse, Christina König, Kevin Roedl, Walter Jäger, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Charlotte Kloft, Valentin Fuhrmann

Publikováno v: Annals of Intensive Care, Vol 10, Iss 1, Pp 1-10 (2020)

Abstract Background Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via chang

Externí odkaz: https://doaj.org/article/5d191904286d467089c35c2382ffdba5

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Akademický článek

Autor: David Busse, Philipp Simon, David Petroff, Christoph Dorn, Lisa Schmitt, Davide Bindellini, Alexander Kratzer, Arne Dietrich, Markus Zeitlinger, Wilhelm Huisinga, Robin Michelet, Hermann Wrigge, Charlotte Kloft

Publikováno v: Pharmaceutics, Vol 13, Iss 9, p 1380 (2021)

Precision dosing of piperacillin/tazobactam in obese patients is compromised by sparse information on target-site exposure. We aimed to evaluate the appropriateness of current and alternative piperacillin/tazobactam dosages in obese and nonobese pati

Externí odkaz: https://doaj.org/article/c60f517415a54cfaa448b2b846e07843

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Akademický článek

Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial

Autor: Philipp Simon, David Petroff, David Busse, Jana Heyne, Felix Girrbach, Arne Dietrich, Alexander Kratzer, Markus Zeitlinger, Charlotte Kloft, Frieder Kees, Hermann Wrigge, Christoph Dorn

Publikováno v: Antibiotics, Vol 9, Iss 12, p 931 (2020)

Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index (BMI) ≥ 35 kg/m2) and age-/sex-matched nonobese (18.5 kg/m2 ≥ BMI ≤ 30 kg/

Externí odkaz: https://doaj.org/article/6442c100172c4f1590ef2a4b1170fd99

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Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients

Autor: David Busse, Philipp Simon, Lisa Schmitt, David Petroff, Christoph Dorn, Arne Dietrich, Markus Zeitlinger, Wilhelm Huisinga, Robin Michelet, Hermann Wrigge, Charlotte Kloft

Publikováno v: Clinical Pharmacokinetics. 61:655-672

Background and objectives: A quantitative evaluation of the PK of meropenem, a broad-spectrum ��-lactam antibiotic, in plasma and interstitial space fluid (ISF) of subcutaneous adipose tissue of obese patients is lacking as of date. The objective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba6cb25fba91066079742a753581ee1
https://doi.org/10.1007/s40262-021-01070-6

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Industrial Approach to Determine the Relative Contribution of Seven Major UGT Isoforms to Hepatic Glucuronidation

Autor: David Busse, Sara Amberntsson, Sara Leandersson, Malin Darnell, Constanze Hilgendorf

Publikováno v: Journal of Pharmaceutical Sciences. 109:2309-2320

The pharma industry designs increasingly less cytochrome P450 dependent and more metabolically stable drugs, and consequently UGT-metabolism becomes more frequently involved. This study compares 2 glucuronidation RAF-scaling approaches, product forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbf7c18849798d4365b3604d9077c36
https://doi.org/10.1016/j.xphs.2020.03.013

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Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and nonobese patients

Autor: David Busse, Wilhelm Huisinga, Charlotte Kloft, Christoph Dorn, Jens Markus Borghardt, Alice Pevzner, Hermann Wrigge, Philipp Simon, David Petroff, Nahed El-Najjar

Aims: The most suitable method for predicting the glomerular filtration rate (GFR) in obesity is currently debated. Therefore, multiple GFR/creatinine clearance prediction methods were applied to (morbidly) obese and nonobese patients ranging from mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b687e0c4b9022c4f0c8ccf3d03745b
https://refubium.fu-berlin.de/handle/fub188/33119

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Comparison of pharmacokinetics and the exposure–response relationship of dapagliflozin between adolescent/young adult and adult patients with type 1 diabetes mellitus

Autor: Torben Biester, Thomas Danne, Markus F. Scheerer, David W. Boulton, Weifeng Tang, Joanna Parkinson, Viktor Sokolov, David Busse

Publikováno v: Br J Clin Pharmacol

Aims To quantitatively compare pharmacokinetics (PK) and the exposure-response (ER) relationship of the sodium-glucose cotransporter-2 inhibitor, dapagliflozin, between adolescents/young adults and adults with type 1 diabetes mellitus (T1DM). Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d66e254399fc23b9a572e560802b92
https://doi.org/10.1111/bcp.13981

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Autor: David Petroff, Christoph Dorn, Wilhelm Huisinga, David Busse, Lisa Schmitt, Philipp Simon, Arne Dietrich, Alexander Kratzer, Charlotte Kloft, Robin Michelet, Hermann Wrigge, Davide Bindellini, Markus Zeitlinger

Publikováno v: Pharmaceutics, Vol 13, Iss 1380, p 1380 (2021)
Pharmaceutics
Volume 13
Issue 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3c064973558d2fdbba3aa56300e4fd

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Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial

Autor: Alexander Kratzer, Arne Dietrich, Felix Girrbach, Philipp Simon, Hermann Wrigge, Jana Heyne, Frieder Kees, David Petroff, Christoph Dorn, Markus Zeitlinger, Charlotte Kloft, David Busse

Publikováno v: Antibiotics, Vol 9, Iss 931, p 931 (2020)
Antibiotics
Volume 9
Issue 12

Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index (BMI) &ge
35 kg/m2) and age-/sex-matched nonobese (18.5 kg/m2 &ge
BMI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5896eb6519638a6515f3136586d8fe
https://www.mdpi.com/2079-6382/9/12/931

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Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Reponse Exemplified by Levofloxacin

Autor: André Schaeftlein, Robin Michelet, Alexander Solms, Wilhelm Huisinga, David Busse, Luis Ilia, Charlotte Kloft, Markus Zeitlinger

Publikováno v: Pharmaceutical Research

Purpose Systematic comparison of analysis methods of clinical microdialysis data for impact on target-site drug exposure and response. Methods 39 individuals received a 500 mg levofloxacin short-term infusion followed by 24-h dense sampling in plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43597d570eeb6ff3f30c9f3811dec4ee
https://pubmed.ncbi.nlm.nih.gov/33723793

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