Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8

Autor: Frederick W, Goldberg, Attilla K T, Ting, David, Beattie, Gillian M, Lamont, Charlene, Fallan, M Raymond V, Finlay, Beth, Williamson, Marianne, Schimpl, Alexander R, Harmer, Oladipupo B, Adeyemi, Pär, Nordell, Anna S, Cronin, Mercedes, Vazquez-Chantada, Derek, Barratt, Antonio, Ramos-Montoya, Elaine B, Cadogan, Barry R, Davies

Publikováno v: ACS medicinal chemistry letters. 13(8)

The DNA-PK complex is activated by double-strand DNA breaks and regulates the non-homologous end-joining repair pathway; thus, targeting DNA-PK by inhibiting the DNA-PK catalytic subunit (DNA-PKcs) is potentially a useful therapeutic approach for onc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2661b30d6b91249b7feab29e38d45bb4
https://pubmed.ncbi.nlm.nih.gov/35978693

Does it par-tickle?: Investigating the relationship between mid-air haptics and visual representations of surface textures

Autor: Katarzyna Wojna, Orestis Georgiou, David Beattie, Michael Wright, Christof Lutteroth

Publikováno v: Wojna, K, Georgious, O, Beattie, D, Wright, M & Lutteroth, C 2023, ' Does it par-tickle?: Investigating the relationship between mid-air haptics and visual representations of surface textures ', IEEE Transactions on Haptics, pp. 1-6 . https://doi.org/10.1109/TOH.2023.3272951

Mid-air haptic feedback technology produces tactile sensations that are felt without the need for physical interactions. However, mid-air haptic experiences need to be congruent with visual cues to reflect user expectations. To overcome this, we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf107ba1619bb94653a2107e33eb5bfe
https://purehost.bath.ac.uk/ws/files/277686044/Does_it_particle_wh_23_1_.pdf

Nanoscale Iodophoric Poly(Vinyl Amide) Coatings for the Complexation and Release of Iodine for Antimicrobial Surfaces

Autor: Erna Wulandari, Kaushik Bilimoria, Marta Krasowska, Sameer Al-Bataineh, David Beattie, Todd Gillam, Wei Ge, Jason Whittle, Edgar H. H. Wong, Anton Blencowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4552f21176fd5502366d4b69f2a834e6
https://doi.org/10.2139/ssrn.4420975

Quantification of peripheral blood mononuclear cell (PBMC) glycogen as a novel biomarker for therapeutic intervention in Pompe disease

Autor: Terrence F. Satterfield, Daniela Linzner, Poojan Suri, Samnang Tep, Rebeca M. Choy, Taru Gujral, Eva Situ, Yannan Xi, David Beattie, Sarah B. Noonberg, Sanjay Chandriani, Julie Ullman, Eric Green

Publikováno v: Molecular Genetics and Metabolism. 138:107304

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbdd7931ed5ad357a1829d200a10ae65
https://doi.org/10.1016/j.ymgme.2022.107304

Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional study

Autor: Philippa Wood, David Beattie, Peter M. Gillett, Thom O'Neill, Richard F.M. Chin, Deepa J Patil

Publikováno v: O'Neill, T, Gillett, P M, Wood, P, Beattie, D, Patil, D J & Chin, R F 2021, ' Prevalence of neurological problems in a community-based sample of paediatric coeliac disease : a cross-sectional study ', Archives of Disease in Childhood . https://doi.org/10.1136/archdischild-2021-321770

BackgroundThe prevalence of and risk factors for neurological problems in childhood coeliac disease (CD) are unclear.MethodsWe performed a cross-sectional, community-based audit of CD in children diagnosed from January 2010 to December 2016 in Lothia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258a9696a4e59279c872fa03b803fc01
https://pubmed.ncbi.nlm.nih.gov/34583921