Zobrazeno 1 - 10
of 7 425
pro vyhledávání: '"Davey Smith"'
Autor:
Urvi Parikh, Amy Heaps, Daniela Moisi, Kelley Gordon, John Mellors, Manish Choudhary, Rinki Deo, Carlee Moser, Paul Klekotka, Alan Landay, Judith Currier, Joseph Eron, Kara Chew, Davey Smith, Jonathan Li, Scott Sieg, ACTIV-2/A5401 Study Team
Publikováno v:
Pathogens and Immunity, Vol 9, Iss 2 (2024)
Background: Assessing the breadth and duration of antigen-specific binding antibodies provides valuable information for evaluating interventions to treat or prevent SARS-CoV-2 infection. Multiplex immunoassays are a convenient method for rapid measur
Externí odkaz:
https://doaj.org/article/370dd23cdf414e01a8ece2d10d410282
Autor:
Katya Corado, Kara Chew, Mark Giganti, Ying Mu, Courtney Fletcher, Judith Currier, Eric Daar, David Wohl, Jonathan Li, Carlee Moser, Justin Ritz, Arzhang Javan, Gene Neytman, Marina Caskey, Michael Hughes, Davey Smith, Joseph Eron, ACTIV-2/A5401 Study Team
Publikováno v:
Pathogens and Immunity, Vol 9, Iss 1 (2024)
Background: Outpatient COVID-19 monoclonal antibody (mAb) treatment via subcutaneous delivery, if effective, overcomes the logistical burdens of intravenous administration. Methods: ACTIV-2/A5401 was a randomized, masked placebo-controlled platform
Externí odkaz:
https://doaj.org/article/ac470b99dab5435b9837e2685a00d534
The importance of appropriate selection of clinical endpoints in outpatient COVID-19 clinical trials
Autor:
Kristian Thorlund, Davey Smith, Christopher Linsell, Nicholas White, Christopher Butler, David Boulware, Judith Currier, Ofir Harari, Edouard Lhomme, Nathalie Strub-Wourgaft, Stacey Adam, Edward Mills
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-5 (2023)
Abstract Clinical trial endpoints must be carefully and intentionally selected so that the results of the trial can be used to inform policy- and decision-making. The relative importance of potential endpoints often depends on the stakeholder, with p
Externí odkaz:
https://doaj.org/article/66d021901bcc41f9a3dde635bf62b6b8
Autor:
Oriol Mitjà, Gilmar Reis, David R. Boulware, Adam M. Spivak, Ammar Sarwar, Christine Johnston, Brandon Webb, Michael D. Hill, Davey Smith, Peter Kremsner, Marla Curran, David Carter, Jim Alexander, Marc Corbacho, Todd C. Lee, Katherine Huppler Hullsiek, Emily G. McDonald, Rachel Hess, Michael Hughes, Jared M. Baeten, Ilan Schwartz, Luanne Metz, Lawrence Richer, Kara W. Chew, Eric Daar, David Wohl, Michael Dunne
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 524-535 (2023)
Abstract Hydroxychloroquine (HCQ) was initially promoted as an oral therapy for early treatment of coronavirus disease 2019 (COVID‐19). Conventional meta‐analyses cannot fully address the heterogeneity of different designs and outcomes of randomi
Externí odkaz:
https://doaj.org/article/2f0332ecf5a2428ebd4d3c3b0d83894f
Autor:
Hyesun Jang, Saibyasachi Choudhury, Yanbao Yu, Benjamin L. Sievers, Terri Gelbart, Harinder Singh, Stephen A. Rawlings, Amy Proal, Gene S. Tan, Yu Qian, Davey Smith, Marcelo Freire
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17958- (2023)
A growing number of studies indicate that coronavirus disease 2019 (COVID-19) is associated with inflammatory sequelae, but molecular signatures governing the normal versus pathologic convalescence process have not been well-delineated. Here, we char
Externí odkaz:
https://doaj.org/article/8f05006814e14d6b93657fafcf92c927
Autor:
John Kanazawa, Sara Gianella, Susanna Concha-Garcia, Jeff Taylor, Andy Kaytes, Christopher Christensen, Hursch Patel, Samuel Ndukwe, Stephen A. Rawlings, Steven Hendrickx, Susan Little, Brandon Brown, Davey Smith, Karine Dubé
Publikováno v:
BMC Medical Ethics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background One of the next frontiers in HIV research is focused on finding a cure. A new priority includes people with HIV (PWH) with non-AIDS terminal illnesses who are willing to donate their bodies at the end-of-life (EOL) to advance the
Externí odkaz:
https://doaj.org/article/ee341c50d8c1468499212ea22cea5a63
Autor:
Karine Dubé, John Kanazawa, Lynda Dee, Jeff Taylor, John A. Sauceda, Sara Gianella, Davey Smith, Steven G. Deeks, Michael J. Peluso
Publikováno v:
AIDS Research and Therapy, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background An increasing number of HIV cure trials involve combining multiple potentially curative interventions. Until now, considerations for designing and implementing complex combination HIV cure trials have not been thoroughly considere
Externí odkaz:
https://doaj.org/article/f0671fb818744d6a8b7790caf789deca
Autor:
Arthur E. Frankel, Renuka Reddy, Kayla R. DeSuza, Khaled Deeb, Aaron F. Carlin, Davey Smith, Yushuang Xie, Eknath Naik, Richard T. Silver, Hans C. Hasselbalch
Publikováno v:
Clinical Case Reports, Vol 9, Iss 4, Pp 2228-2235 (2021)
Abstract An 83‐year‐old female had asymptomatic SARS‐CoV‐2 infection while taking ruxolitinib. She remained RT‐PCR positive for viral RNA for >120 days, and Pegylated interferon for 4 weeks led to viral RNA clearance. The observations suppo
Externí odkaz:
https://doaj.org/article/1b3e4bbc4f1d4394b1fe594cfe958103
Autor:
Karine Dubé, Sara Gianella, Susan Concha-Garcia, Susan J Little, Andy Kaytes, Jeff Taylor, Kushagra Mathur, Sogol Javadi, Anshula Nathan, Hursch Patel, Stuart Luter, Sean Philpott-Jones, Brandon Brown, Davey Smith
Publikováno v:
BMC Medical Ethics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background The U.S. National Institute of Allergies and Infectious Diseases (NIAID) and the National Institute of Mental Health (NIMH) have a new research priority: inclusion of terminally ill persons living with HIV (PLWHIV) in HIV cure-rel
Externí odkaz:
https://doaj.org/article/b8ecaedbf4eb4122bab3a0256762527c
Autor:
Sogol S Javadi, Kushagra Mathur, Susanna Concha-Garcia, Hursch Patel, Kelly E Perry, Megan Lo, Jeff Taylor, Andy Kaytes, Susan Little, Sara Gianella, Davey Smith, Karine Dubé
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250882 (2021)
As end-of-life (EOL) HIV cure-related research expands, understanding perspectives of participants' next-of-kin (NOK) is critical to maintaining ethical study conduct. We conducted two small focus groups and two one-on-one interviews using focus grou
Externí odkaz:
https://doaj.org/article/66aac9ec4042441dbe5d673305723409