Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer.

Autor: Burke, J R, Witmer, M R, Zusi, F C, Gregor, K R, Davern, L B, Padmanabha, R, Swann, R T, Smith, D, Tredup, J A, Micanovic, R, Manly, S P, Villafranca, J J, Tramposch, K M

Publikováno v: Journal of Biological Chemistry; July 1999, Vol. 274 Issue: 27 p18864-71, 8p

Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice

Autor: Chen, P B, Davern, L B, Aguirre, A

Publikováno v: Infection and Immunity; December 1991, Vol. 59 Issue: 12 p4706-4709, 4p

BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models.

Autor: Burke JR; Dermatology Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA. james.burke@bms.com, Davern LB, Stanley PL, Gregor KR, Banville J, Remillard R, Russell JW, Brassil PJ, Witmer MR, Johnson G, Tredup JA, Tramposch KM

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2001 Jul; Vol. 298 (1), pp. 376-85.

A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface.

Autor: Burke JR; Department of Dermatology Discovery Research, Buffalo, New York, USA., Gregor KR, Padmanabha R, Banville J, Witmer MR, Davern LB, Manly SP, Tramposch KM

Publikováno v: Journal of enzyme inhibition [J Enzyme Inhib] 1998 Jun; Vol. 13 (3), pp. 195-206.

Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: requirement for a Gi alpha-type G-protein.

Autor: Burke JR; Dermatology Discovery Research, Bristol-Myers Squibb Pharmaceutical Research Institute, Buffalo, New York 14213, USA., Davern LB, Gregor KR, Todderud G, Alford JG, Tramposch KM

Publikováno v: Biochimica et biophysica acta [Biochim Biophys Acta] 1997 Sep 05; Vol. 1341 (2), pp. 223-37.