Zobrazeno 1 - 10
of 512
pro vyhledávání: '"Davenport AP"'
Publikováno v:
Scientific Sessions of the American-Heart-Association (AHA)
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Introduction: The peptide apelin acts via G proteins to cause beneficial vasodilation and potent positive inotropy to ameliorate pulmonary arterial hypertension in humans and animal models. Apelin is internalised via β-arrestin. In contrast, with lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::5e29e6b04c5b101d31e23297944673f8
http://hdl.handle.net/10044/1/79718
http://hdl.handle.net/10044/1/79718
Autor:
Davenport, AP, Kennedy, A
Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous ligand for a G protein-coupled receptor encoded by the gene CMKLR1 (also known as ChemR23) and as a consequence the receptor protein was renamed the chemerin rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539cb932efa53ae2e6f21f234431ba4a
https://www.repository.cam.ac.uk/handle/1810/276126
https://www.repository.cam.ac.uk/handle/1810/276126
Autor:
Tarkin, JM, Joshi, FR, Evans, NR, Chowdhury, MM, Figg, NL, Shah, AV, Starks, LT, Martin-Garrido, A, Manavaki, R, Yu, E, Kuc, RE, Grassi, L, Kreuzhuber, R, Kostadima, MA, Frontini, M, Kirkpatrick, PJ, Coughlin, PA, Gopalan, D, Fryer, TD, Buscombe, JR, Groves, AM, Ouwehand, WH, Bennett, MR, Warburton, EA, Davenport, AP, Rudd, JHF
$\textbf{Background}$ Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([$^{18}$F]FDG PET), [$^{18}$F]FDG lacks cell specificity, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::9e71fd93045d55b1470f2df1e9613e87
https://www.repository.cam.ac.uk/handle/1810/263480
https://www.repository.cam.ac.uk/handle/1810/263480
Autor:
Yang, P, Kuc, RE, Brame, AL, Dyson, A, Singer, M, Glen, RC, Cheriyan, J, Wilkinson, IB, Davenport, AP, Maguire, JJ
Aims: Apelin is a predicted substrate for ACE2, a novel therapeutic target. Our aim was to demonstrate the endogenous presence of the putative ACE2 product [Pyr(1)]apelin-13(1-12) in human cardiovascular tissues and to confirm it retains significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a4f20e376b2145b7cf1872a3df8806
Autor:
Yang, P, Read, C, Kuc, RE, Buonincontri, G, Southwood, M, Torella, R, Upton, PD, Crosby, A, Sawiak, SJ, Carpenter, TA, Glen, RC, Morrell, NW, Maguire, JJ, Davenport, AP
BACKGROUND: -Elabela/Toddler (ELA) is a critical cardiac developmental peptide that acts through the G protein-coupled apelin receptor, despite lack of sequence similarity to the established ligand apelin. Our aim was to investigate the receptor phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6bcc1c0968c198e631adc0bb3a732f
https://www.repository.cam.ac.uk/handle/1810/263005
https://www.repository.cam.ac.uk/handle/1810/263005
Autor:
Vesey, AT, Jenkins, WSA, Irkle, A, Moss, A, Sng, G, Forsythe, RO, Clark, T, Roberts, G, Fletcher, A, Lucatelli, C, Rudd, JHF, Davenport, AP, Mills, NL, Al-Shahi Salman, R, Dennis, M, Whiteley, WN, van Beek, EJR, Dweck, MR, Newby, DE
BACKGROUND: Combined positron emission tomography (PET) and computed tomography (CT) can assess both anatomy and biology of carotid atherosclerosis. We sought to assess whether $^{18}$F-fluoride or $^{18}$F-fluorodeoxyglucose can identify culprit and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8712937106c1a314f3751a9e8bee06
Autor:
Miller, E, Czopek, A, Duthie, KM, Kirkby, NS, van de Putte, EEF, Christen, S, Kimmitt, RA, Moorhouse, R, Castellan, RFP, Kotelevtsev, YV, Kuc, RE, Davenport, AP, Dhaun, N, Webb, DJ, Hadoke, PWF
Publikováno v:
Miller, E, Czopek, A, Duthie, K M, Kirkby, N S, van de Putte, E E F, Christen, S, Kimmitt, R A, Moorhouse, R, Castellan, R F P, Kotelevtsev, Y V, Kuc, R E, Davenport, A P, Dhaun, N, Webb, D J & Hadoke, P W F 2017, ' Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling ', Hypertension, vol. 69, no. 2, pp. 275-285 . https://doi.org/10.1161/HYPERTENSIONAHA.115.07031
The role of smooth muscle endothelin$_{B}$ (ET$_{B}$) receptors in regulating vascular function, blood pressure (BP), and neointimal remodeling has not been established. Selective knockout mice were generated to address the hypothesis that loss of sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06fd22aaba9878c33219d3db00641e1
Publikováno v:
Nucleic Acids Res
The International Union of Basic and Clinical Pharmacology (IUPHAR) database IUPHAR DB (http://www.iuphar db.org) is an open access online database providing detailed expert driven annotation of the primary literature on human and rodent receptors an
Autor:
Kennedy, AJ, Yang, P, Read, C, Kuc, RE, Yang, L, Taylor, EJA, Taylor, CW, Maguire, JJ, Davenport, AP
BACKGROUND: Circulating levels of chemerin are significantly higher in hypertensive patients and positively correlate with blood pressure. Chemerin activates chemokine-like receptor 1 (CMKLR1 or ChemR23) and is proposed to activate the "orphan" G-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf04e679f4ee1ebe53cdf2edec0632b4
https://www.repository.cam.ac.uk/handle/1810/263559
https://www.repository.cam.ac.uk/handle/1810/263559
Autor:
Alexander, SP, Kelly, E, Marrion, N, Peters, JA, Benson, HE, Faccenda, E, Pawson, AJ, Sharman, JL, Southan, C, Buneman, OP, Catterall, WA, Cidlowski, JA, Davenport, AP, Fabbro, D, Fan, G, McGrath, JC, Spedding, M, Davies, JA, CGTP Collaborators
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::0315a129fd9fd869d2ebce2d301bfbcf
https://www.repository.cam.ac.uk/handle/1810/263554
https://www.repository.cam.ac.uk/handle/1810/263554