Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLAA2 Transgenic NOD/SCID/IL2RG Null Mice

Autor: Arno R. van der Slik, Sandra Laban, Todd Pearson, Joana R. F. Abreu, Jan W. Drijfhout, Dale L. Greiner, Bart O. Roep, Leonard D. Shultz, Wendy W. J. Unger, Marieke Griffioen, Sacha Mulder-van der Kracht, Dave V. Serreze, Michel G.D. Kester

Publikováno v: PLoS ONE, 7(11):e49213. Public Library of Science
PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e49213 (2012)
Unger, W W J, Pearson, T, Abreu, J R F, Laban, S, van der Slik, A R, Mulder-van der Kracht, S, Kester, M G D, Serreze, D V, Shultz, L D, Griffioen, M, Drijfhout, J W, Greiner, D L & Roep, B O 2012, ' Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLAA2 Transgenic NOD/SCID/IL2RG Null Mice ', PLoS ONE, vol. 7, no. 11, e49213 . https://doi.org/10.1371/journal.pone.0049213
PLoS ONE, 7(11), e49213
PLoS ONE, 7(11)

Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells, direct evidence for their destructive role in-vivo is lacking. To address a destructive role for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4443b3f7e5da18b4b52ddc8005e7770b
https://hdl.handle.net/1887/98067