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pro vyhledávání: '"Dave P. Whalley"'
Autor:
Paul Robert Owen Whittamore, Nikos G. Oikonomakos, Peter W. Kenny, Dave P. Whalley, Ludovic Otterbein, Paul Schofield, Alan Martin Birch
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(2)
A series of substituted 3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors, which have potential as antidiabetic agents, is described. Initial members of the series showed good enzyme inhibitory potency but poor physical properties. Optimisati