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pro vyhledávání: '"Dave Ginzinger"'
Autor:
John Kunich, Serah Choi, Kusum Pandey, Larry Boyle, Bridget Bagus, Yuqiao Shen, Gaston Habets, Frank McCormick, Conrado Soria, Dave Ginzinger, Annie Shen, Clodagh C. O’Shea, Cory R. Nicholas, Leisa Johnson
Publikováno v:
Cancer Cell. 6(6):611-623
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively replicate in p53-defective tumor cells. Here we show that loss of E1B-55K leads to the induct