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pro vyhledávání: '"Dave F. McComsey"'
Autor:
Zhihua Sui, Cuifen Hou, Dave F. McComsey, Evan Opas, Dana L. Johnson, Sandra McKenney, John C. O’Neill, Chaozhong Cai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1239-1242
SAR study of 5-aminooctahydrocyclopentapyrrole-3a-carboxamide scaffold led to identification of several CCR2 antagonists with potent activity in both binding and functional assays. Their cardiovascular safety and pharmacokinetic properties were also