Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Dave, Sprengers"'
Autor:
Wilhelm den Toom, Eva M. Negenman, Francois E.J.A. Willemssen, Erik van Werkhoven, Robert J. Porte, Roeland F. de Wilde, Dave Sprengers, Imogeen E. Antonisse, Ben J.M. Heijmen, Alejandra Méndez Romero
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 49, Iss , Pp 100878- (2024)
Purpose/Objective(s): To evaluate if stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) has a durable effect on tumor control and can be delivered safely. Materials/Methods: Patients included in this retrospective study have bee
Externí odkaz:
https://doaj.org/article/7cc4bd898cf64c86b74cea42d294cceb
Autor:
Yan Li, Patrick P C Boor, Dave Sprengers, Zhu Li, Sonja Buschow, Yisen Tang, Xiaomei Zhuang, Wanhua Feng, Guoying Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Immune checkpoint blockade, which enhances the reactivity of T cells to eliminate cancer cells, has emerged as a potent strategy in cancer therapy. Besides T cells, natural killer (NK) cells also play an indispensable role in tumor surveillance and d
Externí odkaz:
https://doaj.org/article/2aac627a9ae64c3a9cf043c4532e4c52
Autor:
Boris J. B. Beudeker, Rael Guha, Kalina Stoyanova, Jan N. M. IJzermans, Robert A. de Man, Dave Sprengers, Andre Boonstra
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The incidence of hepatocellular carcinoma (HCC) in non-cirrhotic livers is rising significantly, but clear risk factors for screening remain elusive. This study sought to characterize non-cirrhotic HCC etiologies. HCC cases from 2009 to 2020
Externí odkaz:
https://doaj.org/article/9db4c47edbaf4f7eb508af6c03cccdda
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the first and second most common primary liver cancer (PLC). For decades, systemic therapies consisting of tyrosine kinase inhibitors (TKIs) or chemotherapy have formed the cornerstone o
Externí odkaz:
https://doaj.org/article/d7aa1a3be5864ca1bf2a74632baa3fa5
Autor:
Iulia Minciuna, Caroline den Hoed, Adriaan J. van der Meer, Milan J. Sonneveld, Dave Sprengers, Robert J. de Knegt, Jeroen de Jonge, Raoel Maan, Wojciech G. Polak, Sarwa Darwish Murad
Publikováno v:
Transplant International, Vol 36 (2023)
Early detection of liver transplantation (LT) vascular complications enables timely management. Our aim was to assess if routine Doppler ultrasound (rDUS) improves the detection of hepatic artery thrombosis (HAT), portal vein thrombosis (PVT) and hep
Externí odkaz:
https://doaj.org/article/24c8d60a6593482db720ed2e260cbc22
Autor:
Yannick S. Rakké, Lucia Campos Carrascosa, Adriaan A. van Beek, Valeska de Ruiter, Rachelle S. van Gemerden, Michail Doukas, Pascal G. Doornebosch, Maarten Vermaas, Susan ter Borg, Erwin van der Harst, Peter Paul L.O. Coene, Mike Kliffen, Dirk J. Grünhagen, Cornelis Verhoef, Jan N.M. IJzermans, Jaap Kwekkeboom, Dave Sprengers
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 1, Pp 77-97 (2023)
Background & Aims: In contrast to mismatch repair deficient colorectal carcinoma (CRC), MMR proficient (pMMR) CRC does not respond to immune checkpoint blockade. We studied immune checkpoint stimulation via glucocorticoid-induced tumor necrosis facto
Externí odkaz:
https://doaj.org/article/4a888c4532714648a65f508089f7a907
Autor:
Lisanne Noordam, Monique T.A. de Beijer, Shanta Mancham, Isabel Vogler, Patrick P.C. Boor, Valeska de Ruiter, Robbie Luijten, Jan N.M. IJzermans, Ugur Sahin, Marco J. Bruno, Dave Sprengers, Sonja I. Buschow, Jaap Kwekkeboom
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide due to high recurrence rates after curative treatment and being frequently diagnosed at an advanced stage. Immune-checkpoint inhibition (ICPI) has yielded i
Externí odkaz:
https://doaj.org/article/157b3da14c4742598e466ea3411e9ddf
Autor:
Zhouhong Ge, Guoying Zhou, Lucia Campos Carrascosa, Erik Gausvik, Patrick P.C. Boor, Lisanne Noordam, Michael Doukas, Wojciech G. Polak, Türkan Terkivatan, Qiuwei Pan, R. Bart Takkenberg, Joanne Verheij, Joris I. Erdmann, Jan N.M. IJzermans, Maikel P. Peppelenbosch, Jaco Kraan, Jaap Kwekkeboom, Dave Sprengers
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 443-464 (2021)
Background & Aims: TIGIT is a co-inhibitory receptor, and its suitability as a target for cancer immunotherapy in HCC is unknown. PD1 blockade is clinically effective in about 20% of advanced HCC patients. Here we aim to determine whether co-blockade
Externí odkaz:
https://doaj.org/article/89506260ed7f4f479d3b7d6501af3e38
Autor:
Wanlu Cao, Meng Li, Jiaye Liu, Shaoshi Zhang, Lisanne Noordam, Monique M. A. Verstegen, Ling Wang, Buyun Ma, Shan Li, Wenshi Wang, Michiel Bolkestein, Michael Doukas, Kan Chen, Zhongren Ma, Marco Bruno, Dave Sprengers, Jaap Kwekkeboom, Luc J. W. van der Laan, Ron Smits, Maikel P. Peppelenbosch, Qiuwei Pan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for com
Externí odkaz:
https://doaj.org/article/71ee0de1c34f4f6fa934afafed4f5a27
Autor:
Zhouhong Ge, Jean C.A. Helmijr, Maurice P.H.M. Jansen, Patrick P.C. Boor, Lisanne Noordam, Maikel Peppelenbosch, Jaap Kwekkeboom, Jaco Kraan, Dave Sprengers
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101073- (2021)
Background and aims: Circulating tumor cells (CTCs) or circulating tumor DNA (ctDNA) may be used for diagnostic or prognostic purposes in patients with hepatocellular carcinoma (HCC). We aim to determine whether CTCs or ctDNA are suitable to determin
Externí odkaz:
https://doaj.org/article/591e1e52f33c46c38f40316de973d6aa