Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Dave, Mugan"'
Autor:
Harold Nijhuis, Jan-Willem Kallewaard, Johan van de Minkelis, Willem-Jan Hofsté, Lars Elzinga, Philippa Armstrong, Ismaïl Gültuna, Emre Almac, Ganesan Baranidharan, Serge Nikolic, Ashish Gulve, Jan Vesper, Birte E. Dietz, Dave Mugan, Frank J. P. M. Huygen
Publikováno v:
Pain and Therapy, Vol 13, Iss 5, Pp 1119-1136 (2024)
Abstract Introduction Closed-loop spinal cord stimulation (CL-SCS) is a recently introduced system that records evoked compound action potentials (ECAPs) from the spinal cord elicited by each stimulation pulse and uses this information to automatical
Externí odkaz:
https://doaj.org/article/93af0142dde4432b82140525a803b9d5
Publikováno v:
Bioelectronic Medicine, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Background Preclinical models of spinal cord stimulation (SCS) are lacking objective measurements to inform translationally applicable SCS parameters. The evoked compound action potential (ECAP) represents a measure of dorsal column fiber ac
Externí odkaz:
https://doaj.org/article/bc96dd3025e24b22b6817b788fe8cd03
Autor:
Harold J. A. Nijhuis, Willem-Jan Hofsté, Imre P. Krabbenbos, Birte E. Dietz, Dave Mugan, Frank Huygen
Publikováno v:
Pain and Therapy, Vol 12, Iss 5, Pp 1221-1233 (2023)
Abstract Introduction A novel closed-loop spinal cord stimulation (SCS) system has recently been approved for use which records evoked compound action potentials (ECAPs) from the spinal cord and utilizes these recordings to automatically adjust the s
Externí odkaz:
https://doaj.org/article/d488ac4bdb18401881ce544ae76da545
Autor:
Gerrit Eduard Gmel, Rosana Santos Escapa, Teddy Edmond Benkohen, Dave Mugan, John Louis Parker, Stefano Palmisani
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Spinal cord stimulation (SCS) treatment for chronic pain relies on the activation of primary sensory fibres ascending to the brain in the dorsal columns. While the efficacy of SCS has been demonstrated, the precise mechanism of action and nature of t
Externí odkaz:
https://doaj.org/article/3daeef088dcc428eb39ea65ab2387de5
Publikováno v:
IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol 31, Pp 4653-4660 (2023)
This manuscript proposes an electrical definition of therapeutic dose for spinal-cord systems used for the treatment of chronic pain, analogous to the pharmacological definition. Dose-response relationships are fundamental to pharmacology, radio-ther
Externí odkaz:
https://doaj.org/article/9a1aa87bfb0a4f24a0cfeb1784c34ed7
Autor:
Gerrit E. Gmel, Paul F. Vollebregt, Marjolein E. G. Thijssen, Rosana Santos Escapa, Eleanor McAlees, Dave Mugan, John L. Parker, Charles H. Knowles
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Intra-operative electrode placement for sacral neuromodulation (SNM) relies on visual observation of motor contractions alone, lacking complete information on neural activation from stimulation. This study aimed to determine whether electrophysiologi
Externí odkaz:
https://doaj.org/article/693e021480724f18b0bc585266aafa7d
Autor:
Gerrit Eduard Gmel, Rosana Santos Escapa, John L. Parker, Dave Mugan, Adnan Al-Kaisy, Stefano Palmisani
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
BackgroundThe effect of spinal cord stimulation (SCS) amplitude on the activation of dorsal column fibres has been widely studied through the recording of Evoked Compound Action Potentials (ECAPs), the sum of all action potentials elicited by an elec
Externí odkaz:
https://doaj.org/article/335350445a25492d81821603065fe8ef
Publikováno v:
Neuromodulation: Technology at the Neural Interface. 25:64-74
Objectives The study aimed to assess the feasibility of recording electrically evoked compound action potentials (ECAPs) from the rat spinal cord. To achieve this, we characterized electrophysiological responses of dorsal column (DC) axons from elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b664f758f6ebc4b7143df7f1ab1cca6
https://doi.org/10.1111/ner.13480
https://doi.org/10.1111/ner.13480
Autor:
Nagy, Mekhail, Robert M, Levy, Timothy R, Deer, Leonardo, Kapural, Sean, Li, Kasra, Amirdelfan, Corey W, Hunter, Steven M, Rosen, Shrif J, Costandi, Steven M, Falowski, Abram H, Burgher, Jason E, Pope, Christopher A, Gilmore, Farooq A, Qureshi, Peter S, Staats, James, Scowcroft, Tory, McJunkin, Jonathan, Carlson, Christopher K, Kim, Michael I, Yang, Thomas, Stauss, Julie, Pilitsis, Lawrence, Poree, Dan, Brounstein, Samuel, Gilbert, Gerrit E, Gmel, Robert, Gorman, Ian, Gould, Erin, Hanson, Dean M, Karantonis, Abeer, Khurram, Angela, Leitner, Dave, Mugan, Milan, Obradovic, Zhonghua, Ouyang, John, Parker, Peter, Single, Nicole, Soliday
Publikováno v:
JAMA Neurol
Chronic pain is debilitating and profoundly affects health-related quality of life. Spinal cord stimulation (SCS) is a well-established therapy for chronic pain; however, SCS has been limited by the inability to directly measure the elicited neural r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::052279d55c73e76a06fbbc7eb12a9ddf
https://pubmed.ncbi.nlm.nih.gov/35156999
https://pubmed.ncbi.nlm.nih.gov/35156999
Autor:
Nagy Mekhail, Robert M Levy, Timothy R Deer, Leonardo Kapural, Sean Li, Kasra Amirdelfan, Corey W Hunter, Steven M Rosen, Shrif J Costandi, Steven M Falowski, Abram H Burgher, Jason E Pope, Christopher A Gilmore, Farooq A Qureshi, Peter S Staats, James Scowcroft, Jonathan Carlson, Christopher K Kim, Michael I Yang, Thomas Stauss, Lawrence Poree, Dan Brounstein, Robert Gorman, Gerrit E. Gmel, Erin Hanson, Dean M. Karantonis, Abeer Khurram, Deidre Kiefer, Angela Leitner, Dave Mugan, Milan Obradovic, John Parker, Peter Single, Nicole Soliday
Publikováno v:
The Lancet Neurology. 19:123-134
Summary Background Spinal cord stimulation has been an established treatment for chronic back and leg pain for more than 50 years; however, outcomes are variable and unpredictable, and objective evidence of the mechanism of action is needed. A novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1226edd834486c9e2c412228bb01ac94
https://doi.org/10.1016/s1474-4422(19)30414-4
https://doi.org/10.1016/s1474-4422(19)30414-4