Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Daunosamine"'
Autor:
Denel-Bobrowska, Marta1 mdenel@biol.uni.lodz.pl, Łukawska, Małgorzata2, Rogalska, Aneta1, Forma, Ewa3, Bryś, Magdalena3, Oszczapowicz, Irena2, Marczak, Agnieszka1
Publikováno v:
Toxicology & Applied Pharmacology. Dec2016, Vol. 313, p159-169. 11p.
Autor:
Csatayová, Kristína1, Davies, Stephen G.1 steve.davies@chem.ox.ac.uk, Ford, J. Gair2, Lee, James A.1, Roberts, Paul M.1, Thomson, James E.1
Publikováno v:
Journal of Organic Chemistry. 12/20/2013, Vol. 78 Issue 24, p12397-12408. 12p.
Publikováno v:
ACS Chemical Biology. 17:3331-3340
Many small molecule natural products are decorated with sugar moieties that are essential for their biological activity. A considerable number of natural product glycosides and their derivatives are clinically important therapeutics. Anthracyclines l
Autor:
Zinaida S. Klemenkova, Lada V. Anikina, Oleg I. Artyushin, Valery K. Brel, Aleksandra A. Moiseeva
Publikováno v:
Medicinal Chemistry Research. 30:564-573
Modification of daunorubicin on its NH2 moiety is a well-established synthetic approach to obtain novel derivatives of this compound. Moreover, the daunosamine moiety of this antibiotic is considered to be the most sensitive part of a molecule in ter
Publikováno v:
Bioorganic Synthesis : An Introduction, 2016.
Externí odkaz:
https://doi.org/10.1093/oso/9780199860531.003.0006
Publikováno v:
Green Chemistry; 2015, Vol. 17 Issue 1, p225-230, 6p
Publikováno v:
ChemMedChem. 15(11)
Anthracyclines are ranked among the most effective chemotherapeutics against cancer. They are glycoside drugs comprising the amino sugar daunosamine linked to a hydroxy anthraquinone aglycone, and act by DNA intercalation, oxidative stress generation
Autor:
Matyjaszczyk, Karolina, Kolonko, Marta, Gonciarz-Dytman, Anna, Oszczapowicz, Irena, Łukawska, Małgorzata, Jawień, Wojciech, Chłopicki, Stefan, Walczak, Maria
Publikováno v:
Journal of Chromatography B. 1060:44-52
The thermodynamic acid dissociation constants (pKa1 and pKa2) of 16 anthracycline antibiotics, including doxorubicin (DOX) and daunorubicin (DAU), their epimers, epidoxorubicin (EDOX) and epidaunorubicin (EDAU), as well as novel anthracycline derivat
Publikováno v:
Life Sciences. 178:1-8
Doxorubicin (DOX) is one of the most commonly used and effective chemotherapeutic agents. Despite its clinical benefits, the use of DOX is often limited by serious adverse effects, such as severe cardiotoxicity and myelosuppression. Recent progress i
Autor:
Elżbieta Zwierkowska, Adriana Palinska-Saadi, Magdalena Lukasiewicz, Malgorzata Lukawska, Selim Achmatowicz, Magdalena Maj-Zurawska, Janusz Oszczapowicz, Irena Oszczapowicz
Publikováno v:
Electroanalysis. 29:172-181
Daunorubicin (DAU) is one of the anticancer drugs widely applied in therapy although it reveals high toxicity. As a result of the search for new derivatives of anthracyclines with better biological properties, amidino antracyclines were invented. The