An Orally Bioavailable (Mice) Prodrug of Glutathione

Autor: Daune L. Crankshaw, Jacquie E. Briggs, Robert Vince, Herbert T. Nagasawa

Publikováno v: Antioxidants, Vol 10, Iss 6, p 939 (2021)

L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide

Externí odkaz: https://doaj.org/article/b4f7dc7b088a4f1c9654242ec8608bb3

Development of sulfanegen for mass cyanide casualties

Autor: Steven E. Patterson, Jacquie E. Briggs, Chakravarthy V. Vinnakota, Robert Vince, Brian A. Logue, Bryant Moeller, Herbert T. Nagasawa, Daune L. Crankshaw, Michael W. Stutelberg

Publikováno v: Annals of the New York Academy of Sciences. 1374:202-209

Cyanide is a metabolic poison that inhibits the utilization of oxygen to form ATP. The consequences of acute cyanide exposure are severe; exposure results in loss of consciousness, cardiac and respiratory failure, hypoxic brain injury, and dose-depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6f7d5a37f9ddf11245a3db6e2bb9ab
https://doi.org/10.1111/nyas.13114

Cyanide Antidotes for Mass Casualties: Water-Soluble Salts of the Dithiane (Sulfanegen) from 3-Mercaptopyruvate for Intramuscular Administration

Autor: Alexandre R. Monteil, Daune L. Crankshaw, Robert Vince, Steven E. Patterson, Herbert T. Nagasawa, Jonathan F. Cohen

Publikováno v: Journal of Medicinal Chemistry. 56:1346-1349

Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-solub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6822c30b8b40456dc45d7d1a97474702
https://doi.org/10.1021/jm301633x

A novel paradigm for assessing efficacies of potential antidotes against neurotoxins in mice

Autor: Herbert T. Nagasawa, David J.W. Goon, David Delong, Michael A. Kuskowski, Jacquie E. Briggs, Steven E. Patterson, Daune L. Crankshaw

Publikováno v: Toxicology Letters. 175:111-117

Historically, antidotal potencies of cyanide antagonists were measured as increases in the experimental LD(50) for cyanide elicited by the antidotes. This required the use of high doses of cyanide following pre-treatment with the putative antidote. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee58c1211918cd84d2c2eeaed07537fb
https://doi.org/10.1016/j.toxlet.2007.10.001

The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning

Autor: Daune L. Crankshaw, Renate B. Pilz, Gerry R. Boss, Timothy D. Bigby, Herbert T. Nagasawa, Adriano Chan, Steven E. Patterson, Jackie E. Briggs, Sari B. Mahon, Alexandre R. Monteil, Matthew Brenner, Joseph A. Kozocas

Publikováno v: Chan, A; Crankshaw, DL; Monteil, A; Patterson, SE; Nagasawa, HT; Briggs, JE; et al.(2011). The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clinical Toxicology, 49(5), 366-373. doi: 10.3109/15563650.2011.584879. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2g51w75f

Context. Cyanide is a component of smoke in residential and industrial fires, and accidental exposure to cyanide occurs in a variety of industries. Moreover, cyanide has the potential to be used by terrorists, particularly in a closed space such as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd6d2deeb15e9979b306bd5cf162f0c
https://pubmed.ncbi.nlm.nih.gov/21740135