AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

Autor: Reichel FF; University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Dauletbekov DL; University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Klein R; Immunopathology Laboratory, Department of Internal Medicine II, University Hospital Tübingen, Tübingen, Germany., Peters T; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; STZ eyetrial at the Center for Ophthalmology, University of Tübingen, Tübingen, Germany., Ochakovski GA; University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Seitz IP; University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Wilhelm B; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; STZ eyetrial at the Center for Ophthalmology, University of Tübingen, Tübingen, Germany., Ueffing M; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Biel M; Center for Integrated Protein Science Munich (CIPSM) at the Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Wissinger B; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Michalakis S; Center for Integrated Protein Science Munich (CIPSM) at the Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Bartz-Schmidt KU; University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Fischer MD; University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; STZ eyetrial at the Center for Ophthalmology, University of Tübingen, Tübingen, Germany; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: dominik.fischer@uni-tuebingen.de.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2017 Dec 06; Vol. 25 (12), pp. 2648-2660. Date of Electronic Publication: 2017 Aug 31.