Generation and characterization of monoclonal antibodies against pathologically phosphorylated TDP-43.

Autor: Castellanos Otero P; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America., Todd TW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America., Shao W; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America., Jones CJ; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America., Huang K; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America., Daughrity LM; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America., Yue M; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America., Sheth U; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America., Gendron TF; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America., Prudencio M; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America., Oskarsson B; Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America., Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Apr 18; Vol. 19 (4), pp. e0298080. Date of Electronic Publication: 2024 Apr 18 (Print Publication: 2024).

Erratum: Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19.

Autor: Erben Y, Prudencio M, Marquez CP, Jansen-West KR, Heckman MG, White LJ, Dunmore JA, Cook CN, Lilley MT, Qosja N, Song Y, Al Shaikh RH, Daughrity LM, Bartfield JL, Day GS, Oskarsson B, Nicholson KA, Wszolek ZK, Hoyne JB, Gendron TF, Meschia JF, Petrucelli L

Publikováno v: IScience [iScience] 2024 Mar 20; Vol. 27 (4), pp. 109501. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.

Autor: Park J; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Wu Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Shao W; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Gendron TF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA., van der Spek SJF; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA., Sultanakhmetov G; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA; Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Tokyo, 1920397, Japan., Basu A; Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA., Castellanos Otero P; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Jones CJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Jansen-West K; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Daughrity LM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Phanse S; Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA., Del Rosso G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Tong J; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Castanedes-Casey M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Jiang L; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA., Libera J; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA., Oskarsson B; Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA., Sanders DW; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA., Brangwynne CP; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Howard Hughes Medical Institute, Princeton, NJ 08544, USA., Emili A; Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA., Wolozin B; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA. Electronic address: petrucelli.leonard@mayo.edu., Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA. Electronic address: zhang.yongjie@mayo.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112822. Date of Electronic Publication: 2023 Jul 19.

Correction: TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A.

Autor: Koike Y, Pickles S, Ayuso VE, Jansen-West K, Qi YA, Li Z, Daughrity LM, Yue M, Zhang YJ, Cook CN, Dickson DW, Ward M, Petrucelli L, Prudencio M

Publikováno v: PLoS biology [PLoS Biol] 2023 Jul 14; Vol. 21 (7), pp. e3002228. Date of Electronic Publication: 2023 Jul 14 (Print Publication: 2023).

Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease.

Autor: Jambeau M; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142.; Department of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland., Meyer KD; Neurimmune AG, Schlieren CH-8952 Switzerland.; Institute for Regenerative Medicine, University of Zurich, CH-8952 Schlieren, Switzerland., Hruska-Plochan M; Department of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland., Tabet R; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Lee CZ; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Ray-Soni A; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Aguilar C; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Savage K; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Mishra N; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Cavegn N; Neurimmune AG, Schlieren CH-8952 Switzerland., Borter P; Neurimmune AG, Schlieren CH-8952 Switzerland., Lin CC; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114., Jansen-West KR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224., Jiang J; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093., Freyermuth F; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Li N; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., De Rossi P; Department of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland., Pérez-Berlanga M; Department of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland., Jiang X; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Daughrity LM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224., Pereira J; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Narayanan S; Biogen, Cambridge, MA 02142., Gu Y; Biogen, Cambridge, MA 02142., Dhokai S; Biogen, Cambridge, MA 02142., Dalkilic-Liddle I; Biogen, Cambridge, MA 02142., Maniecka Z; Department of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland., Weber J; Department of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland., Workman M; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114., McAlonis-Downes M; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093., Berezovski E; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224., Berry J; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114., Wainger BJ; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142., Kankel MW; Biogen, Cambridge, MA 02142., Rushe M; Biogen, Cambridge, MA 02142., Hock C; Neurimmune AG, Schlieren CH-8952 Switzerland.; Institute for Regenerative Medicine, University of Zurich, CH-8952 Schlieren, Switzerland., Nitsch RM; Neurimmune AG, Schlieren CH-8952 Switzerland.; Institute for Regenerative Medicine, University of Zurich, CH-8952 Schlieren, Switzerland., Cleveland DW; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224., Gendron TF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224., Montrasio F; Neurimmune AG, Schlieren CH-8952 Switzerland., Grimm J; Neurimmune AG, Schlieren CH-8952 Switzerland., Polymenidou M; Department of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland., Lagier-Tourenne C; Department of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.; Broad Institute of Harvard and MIT, Cambridge, MA 02142.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 06; Vol. 119 (49), pp. e2123487119. Date of Electronic Publication: 2022 Dec 01.