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A Pan-cancer analysis reveals high-frequency genetic alterations in mediators of signaling by the tgf-β superfamily

Autor: Korkut, Anil, Zaidi, Sobia, Kanchi, Rupa S., Rao, Shuyun, Gough, Nancy R., Schultz, Andre, Li, Xubin, Lorenzi, Philip L., Berger, Ashton C., Robertson, Gordon, Kwong, Lawrence N., Datto, Mike, Roszik, Jason, Ling, Shiyun, Ravikumar, Visweswaran, Manyam, Ganiraju, Rao, Arvind, Shelley, Simon, Liu, Yuexin, Ju, Zhenlin, Hansel, Donna, Velasco, Guillermo de, Pennathur, Arjun, Andersen, Jesper B., O'Rourke, Colm J., Ohshiro, Kazufumi, Jogunoori, Wilma, Nguyen, Bao-Ngoc, Li, Shulin, Osmanbeyoglu, Hatice U., Ajani, Jaffer A., Mani, Sendurai A., Houseman, Andres, Wiznerowicz, Maciej, Chen, Jian, Gu, Shoujun, Ma, Wencai, Zhang, Jiexin, Tong, Pan, Cancer Genome Atlas Research Network

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediator

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