Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Datong Tang"'
Autor:
Datong Tang, Lu Ying
Publikováno v:
Current Topics in Medicinal Chemistry. 10:1441-1469
Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithromycin and telithromycin. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385636d3c19ff75dd9b1eec433c4e638
https://doi.org/10.2174/156802610792232042
https://doi.org/10.2174/156802610792232042
Autor:
Yat Sun Or, Zhigang Chen, Datong Tang, Heejin Kim, Yonghua Gai, Zhe Wang, Guoqiang Wang, Guoyou Xu, Ly Tam Phan
Publikováno v:
Organic Process Research & Development. 14:504-510
A multistep, practical, and cost-effective synthesis of novel bridged bicyclic macrolide drug candidate EDP-420 (1) is described. Starting from inexpensive and commercially available erythromycin A 9-oxime, the current chemical process involves a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bef25fede5f95fbfd1ff01d49f540090
https://doi.org/10.1021/op900228u
https://doi.org/10.1021/op900228u
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5078-5082
We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52923a0dbe11c44a0b0da894047d00ff
https://doi.org/10.1016/j.bmcl.2008.07.118
https://doi.org/10.1016/j.bmcl.2008.07.118
Publikováno v:
Journal of the American Chemical Society. 126:4310-4317
The first total synthesis of the ristocetin aglycon is described employing a modular and highly convergent strategy. An effective 12-step (12% overall) synthesis of the ABCD ring system 3 from its amino acid subunits sequentially features an intramol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb29e151cf3cc5f81d5a149555791b64
https://doi.org/10.1021/ja039795a
https://doi.org/10.1021/ja039795a
Publikováno v:
Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies from the Pharmaceutical Industry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e97d0e4c58c805423944c161770154e6
https://doi.org/10.1002/9783527658909.ch14
https://doi.org/10.1002/9783527658909.ch14
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 58:o615-o617
The title compound, C13H13Cl5O4, is a highly substituted tricyclic fused-ring diene formed when a nonachlorohomocubane slowly reacts with anhydrous sodium methoxide in tetrahydrofuran at room temperature. Four chloro substituents on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17429b6bf44902c3994e0e107a0f163
https://doi.org/10.1107/s1600536802007705
https://doi.org/10.1107/s1600536802007705
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 58:o562-o564
The title compound, C10H4Cl8O2, is a polychloro-substituted tricyclic diene, comprised of a norbornene section with a cis–endo cyclopentene fused to it. This strained ring system has been described before, but not with the two hydroxyl substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58f74d028c5c80e532ee3040446a622a
https://doi.org/10.1107/s1600536802006992
https://doi.org/10.1107/s1600536802006992
Publikováno v:
Tetrahedron Letters. 43:3-5
The structures of various perhalodiones available by isomerization of the Diels–Alder dimers of tetrachloro- and tetrabromocyclopentadienone have finally been determined unambiguously.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f08cbaf5acdaee47fc5edb0c19c32ef
https://doi.org/10.1016/s0040-4039(01)02085-8
https://doi.org/10.1016/s0040-4039(01)02085-8
Autor:
Guoyou Xu, Zhe Wang, Datong Tang, Alexander Polemeropoulos, Yat Sun Or, Yonghua Gai, Zhigang Chen
Publikováno v:
ChemInform. 40
The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including resistant respiratory tract p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460558a9afc7038e5efd25eb06278970
https://doi.org/10.1002/chin.200916201
https://doi.org/10.1002/chin.200916201
Autor:
Brendan M. Crowley, Casey Cameron Mccomas, Jason A. Moss, Dale L. Boger, Wanlong Jiang, Datong Tang, Jutta Wanner
Publikováno v:
ChemInform. 34
A general method for the deglycosidation of glycopeptide antibiotics has been developed. Treatment of vancomycin, ristocetin, and ramoplanin with anhydrous HF results in efficient cleavage of the sugars to provide the corresponding aglycons in high y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41622cee94c2fc83f919f3f7890ba2c6
https://doi.org/10.1002/chin.200328229
https://doi.org/10.1002/chin.200328229