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VDAC Solvation Free Energy Calculation by a Nonuniform Size Modified Poisson-Boltzmann Ion Channel Model

Autor: Jemison, Liam, Stahl, Matthew, Dash, Ranjan K., Xie, Dexuan

The Voltage-Dependent Anion Channel (VDAC) protein is the primary conduit for the regulated passage of ions and metabolites into and out of mitochondria. Calculating its solvation free energy is crucial for understanding its stability, function, and

Externí odkaz: http://arxiv.org/abs/2407.01569

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Sandwiched Hybrid Waveguide Platform for Integrated Photonics Application

Autor: Dash, Rahul K, Selvaraja, Shankar Kumar

We propose and demonstrate a hybrid waveguide platform using layered amorphous silicon and silicon nitride. The waveguide offers more degrees of freedom to design waveguides with desired confinement, effective index and polarization birefringence. Un

Externí odkaz: http://arxiv.org/abs/2304.00748

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Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury

Autor: Monti, Christopher, Audi, Said H., Womack, Justin, Hong, Seung-Keun, Yang, Yongqiang, Kim, Joohyun, Dash, Ranjan K.

During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the liver. Our rece

Externí odkaz: http://arxiv.org/abs/2302.05511

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Simulating the Evolution of Signaling Signatures during CART-Cell -- Tumor Cell Interactions

Autor: Shah, Viren, Womack, Justin, Zamora, Anthony E., Terhune, Scott S., Dash, Ranjan K.

Immunotherapies have been proven to have significant therapeutic efficacy in the treatment of cancer. The last decade has seen adoptive cell therapies, such as chimeric antigen receptor T-cell (CART-cell) therapy, gain FDA approval against specific c

Externí odkaz: http://arxiv.org/abs/2302.04338

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