Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.

Autor: Crowther GJ; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Hillesland HK; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Keyloun KR; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Reid MC; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, GlaxoSmithKline, Tres Cantos, Madrid, Spain., Ghidelli-Disse S; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D, Heidelberg, Germany., Leonard SE; Department of Chemistry, University of Washington, Seattle, Washington, United States of America., He P; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Jones JC; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Krahn MM; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Mo JS; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Dasari KS; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Fox AM; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Boesche M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D, Heidelberg, Germany., El Bakkouri M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Rivas KL; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Leroy D; Drug Discovery, Medicines for Malaria Venture, Geneva, Switzerland., Hui R; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Drewes G; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D, Heidelberg, Germany., Maly DJ; Department of Chemistry, University of Washington, Seattle, Washington, United States of America., Van Voorhis WC; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Ojo KK; Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America.

Publikováno v: PloS one [PLoS One] 2016 Mar 02; Vol. 11 (3), pp. e0149996. Date of Electronic Publication: 2016 Mar 02 (Print Publication: 2016).