PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial

Autor: Raman R Gangakhedkar, Ravindra Mohan Pandey, Rakesh Kumar, Randeep Guleria, Manjula Singh, Soumya Swaminathan, George D’Souza, Rashmi Rodrigues, Anand Krishnan, Sanghamitra Pati, Sudipta Mohakud, Anant Mohan, Ramesh Kumar, Prasanta Raghab Mohapatra, Parul Kodan, Rohit Sarin, Baijayantimala Mishra, Geeta Yadav, Deepak Gupta, Anuj Bhatnagar, Sriram Selvaraju, Ritu Gupta, Sandeep Patil, Sourin Bhuniya, Sanjay Mehendale, Samiran Panda, Subrata Kumar Palo, Debasish Hota, Sangeeta Sharma, Srikanth Tripathy, Kiran Katoch, Sindhu Joshi, Somashekar Narasimhaiah, Sangeeta Bhaskar, Rajni Rani, Abdul Mabood Khan, Urvashi B Singh, D K Mitra, Neelam Roy, Amitva Sen Gupta, Vikram Vohra, Neeta Singla, Vijaya Valluri Ansari, Chitra Iravatham, Shilpa Rakh, D K Prudhula, Chala Devi, N Rupa, K Sailaja, Sheela Godbole, Seema Sahay, Suchit Kamble, Megha Mamulwar, Arati Kishor Mane, Ashwini Vinod Shete, Abhijit Vasantrao Kadam, Vineet Chadha, S Uma Shankar, C Ravichandra, S K Tripathy, Dasarathi Das, Tahziba Hussain, B Dwibedi, P R Mohapatra, S C B Cuttack, M R Pattnaik, Sabita Mohapatra, Banu Rekha, Mohan Natarajan, P K Bhavani, D Bella Devaleenal, Syed Hisar, S Devarajulu Reddy, Paul Kumaran, Makhesh Kumar, Poorna Ganga Devi, Sunny Omkar Singh, Devi Pratyush, Vidushi Gupta, Parvathi

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Tuberculosis (TB) continues to be one of the deadliest infectious diseases over the centuries, killing more people worldwide than any other single infectious disease. There is an urgent need for additional strategies which can expedite e

Externí odkaz: https://doaj.org/article/0dfb68c186d44cbe9ab7313c02d81cab

Diagnostic Accuracy of The TrueNat MTB/RIF Assay And Comparison With The Reference Standards To Detect Pulmonary Tuberculosis And Rifampicin Resistance in Sputum Samples From Patients Attending A Tertiary Care Hospital in Bhubaneswar, India

Autor: Braja Sundar Barik, Shritam Das, Khusbu Singh, Sudatta Chandan, Subrat Kumar Swain, Prasanti Nayak, Omkar Abadesh Mishra, Tahziba Hussain, Dasarathi Das, Sanghamitra Pati

Publikováno v: National Journal of Community Medicine, Vol 15, Iss 03 (2024)

Background: A rapid and accurate diagnostic tool is necessary for correct diagnosis and treatment of TB. This study evaluated and compared the sensitivity, specificity and concordance of TrueNAT MTB/RIF assay with smear microscopy, Xpert MTB/RIF and

Externí odkaz: https://doaj.org/article/cf3aa28ffd484fb69cd02cfdcd655358

Impact of cartridge-based nucleic acid amplification test (CBNAAT) introduction on the detection of pulmonary and extra-pulmonary tuberculosis in Bhubaneswar, Odisha

Autor: Himadri Bhusan Bal, Sarita Kar, Sarita Otta, Sujeet Kumar, Suryakanta Samal, Archana Pattnaik, Sunil Swick Rout, Jyotirmayee Turuk, Dasarathi Das, Sanghamitra Pati, Sidhartha Giri

Publikováno v: Indian Journal of Pathology and Microbiology, Vol 66, Iss 4, Pp 764-769 (2023)

Background: Compared to conventional microscopy, the cartridge-based nucleic acid amplification test (CBNAAT, Xpert MTB/RIF, Cepheid, USA) has the dual advantage of higher sensitivity to detect Mycobacterium tuberculosis (M. tb), and the ability to d

Externí odkaz: https://doaj.org/article/5e0ba249b1b54a65ba4a79303c9da5e5

SARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020–January 2021

Autor: Manoj V. Murhekar, Tarun Bhatnagar, Jeromie Wesley Vivian Thangaraj, V. Saravanakumar, Muthusamy Santhosh Kumar, Sriram Selvaraju, Kiran Rade, C.P. Girish Kumar, R. Sabarinathan, Alka Turuk, Smita Asthana, Rakesh Balachandar, Sampada Dipak Bangar, Avi Kumar Bansal, Vishal Chopra, Dasarathi Das, Alok Kumar Deb, Kangjam Rekha Devi, Vikas Dhikav, Gaurav Raj Dwivedi, S. Muhammad Salim Khan, M. Sunil Kumar, Avula Laxmaiah, Major Madhukar, Amarendra Mahapatra, Chethana Rangaraju, Jyotirmayee Turuk, Rajiv Yadav, Rushikesh Andhalkar, K. Arunraj, Dinesh Kumar Bharadwaj, Pravin Bharti, Debdutta Bhattacharya, Jyothi Bhat, Ashrafjit S. Chahal, Debjit Chakraborty, Anshuman Chaudhury, Hirawati Deval, Sarang Dhatrak, Rakesh Dayal, D. Elantamilan, Prathiksha Giridharan, Inaamul Haq, Ramesh Kumar Hudda, Babu Jagjeevan, Arshad Kalliath, Srikanta Kanungo, Nivethitha N. Krishnan, Jaya Singh Kshatri, Alok Kumar, Niraj Kumar, V.G. Vinoth Kumar, G.G.J. Naga Lakshmi, Ganesh Mehta, Nandan Kumar Mishra, Anindya Mitra, K. Nagbhushanam, Arlappa Nimmathota, A.R. Nirmala, Ashok Kumar Pandey, Ganta Venkata Prasad, Mariya Amin Qurieshi, Sirasanambatti Devarajulu Reddy, Aby Robinson, Seema Sahay, Rochak Saxena, Krithikaa Sekar, Vijay Kumar Shukla, Hari Bhan Singh, Prashant Kumar Singh, Pushpendra Singh, Rajeev Singh, Nivetha Srinivasan, Dantuluri Sheethal Varma, Ankit Viramgami, Vimith Cheruvathoor Wilson, Surabhi Yadav, Suresh Yadav, Kamran Zaman, Amit Chakrabarti, Aparup Das, R.S. Dhaliwal, Shanta Dutta, Rajni Kant, A.M. Khan, Kanwar Narain, Somashekar Narasimhaiah, Chandrasekaran Padmapriyadarshini, Krishna Pandey, Sanghamitra Pati, Shripad Patil, Hemalatha Rajkumar, Tekumalla Ramarao, Y.K. Sharma, Shalini Singh, Samiran Panda, D.C.S. Reddy, Balram Bhargava, Tanu Anand, Giridhara R. Babu, Himanshu Chauhan, Tanzin Dikid, Raman R. Gangakhedkar, Shashi Kant, Sanket Kulkarni, J.P. Muliyil, Ravindra Mohan Pandey, Swarup Sarkar, Naman Shah, Aakash Shrivastava, Sujeet K. Singh, Sanjay Zodpe, Anusha Hindupur, P.R. Asish, M. Chellakumar, D. Chokkalingam, Sauvik Dasgupta, M.M.E. Gowtham, Annamma Jose, K. Kalaiyarasi, N.N. Karthik, T. Karunakaran, G. Kiruthika, H. Dinesh Kumar, S. Sarath Kumar, M.P. Sarath Kumar, E. Michaelraj, Josephine Pradhan, E.B. Arun Prasath, D. Gladys Angelin Rachel, Sudha Rani, Amanda Rozario, R. Sivakumar, P. Gnana Soundari, K. Sujeetha, Arya Vinod

Publikováno v: International Journal of Infectious Diseases, Vol 108, Iss , Pp 145-155 (2021)

Background: Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May–June 2020 and 7.1% in August–September 2020. A third serosurvey was conducted between December 2020 a

Externí odkaz: https://doaj.org/article/d50cf56213434e51b4361b33368feaa3

Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity

Autor: Sunil Raghav, Arup Ghosh, Jyotirmayee Turuk, Sugandh Kumar, Atimukta Jha, Swati Madhulika, Manasi Priyadarshini, Viplov K. Biswas, P. Sushree Shyamli, Bharati Singh, Neha Singh, Deepika Singh, Ankita Datey, Kiran Avula, Shuchi Smita, Jyotsnamayee Sabat, Debdutta Bhattacharya, Jaya Singh Kshatri, Dileep Vasudevan, Amol Suryawanshi, Rupesh Dash, Shantibhushan Senapati, Tushar K. Beuria, Rajeeb Swain, Soma Chattopadhyay, Gulam Hussain Syed, Anshuman Dixit, Punit Prasad, Odisha COVID-19 Study Group, ILS COVID-19 Team, Sanghamitra Pati, Ajay Parida, Arvind Kumar Singh, Baijayantimala Mishra, Banajini Parida, Binod Kumar Patro, D. P. Dogra, Dasarathi Das, Deepa Prasad, Dhaneswari Jena, Dharitri Mohapatra, Dinesh Prasad Sahu, Durga Madhab Satapathy, Durgesh Prasad Sahoo, Jayanta Panda, Jaya Singh Khatri, Kaushik Mishra, Manoranjan Satpathy, Nirupama Chaini, Roma Rattan, Sadhu Panda, Sangeeta Das, Somen Kumar Pradhan, Srikanta Kanungo, Sriprasad Mohanty, Subrata Kumar Palo

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has emerged as a global pandemic worldwide. In this study, we used ARTIC primers–based amplicon sequencing to profile 225 SARS-Co

Externí odkaz: https://doaj.org/article/e9abfd3f34aa4946a9789321d1cc855e