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Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice

Autor: Hara, Hideyuki, Miyata, Hironori, Das, Nandita Rani, Chida, Junji, Yoshimochi, Tatenobu, Uchiyama, Keiji, Watanabe, Hitomi, Kondoh, Gen, Yokoyama, Takashi, Sakaguchi, Suehiro

Publikováno v: Journal of Virology. 92(1):e01368

Conformational conversion of the cellular isoform of prion protein PrPC, into the abnormally folded, amyloidogenic isoform, PrPSc, is a key pathogenic event in prion diseases including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::309047545e22fe9e440745eba75ec6ae
https://repo.lib.tokushima-u.ac.jp/111465

Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice.

Autor: Hara H; Division of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, Kuramoto, Tokushima, Japan., Miyata H; Animal Research Center, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan., Das NR; Division of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, Kuramoto, Tokushima, Japan., Chida J; Division of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, Kuramoto, Tokushima, Japan., Yoshimochi T; Division of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, Kuramoto, Tokushima, Japan.; Student Laboratory, Faculty of Medicine, Tokushima University, Kuramoto, Tokushima, Japan., Uchiyama K; Division of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, Kuramoto, Tokushima, Japan., Watanabe H; Laboratory of Integrative Biological Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan., Kondoh G; Laboratory of Integrative Biological Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan., Yokoyama T; National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan., Sakaguchi S; Division of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, Kuramoto, Tokushima, Japan sakaguchi@tokushima-u.ac.jp.

Publikováno v: Journal of virology [J Virol] 2017 Dec 14; Vol. 92 (1). Date of Electronic Publication: 2017 Dec 14 (Print Publication: 2018).