Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Daryl Waggott"'
Autor:
Pablo Cordero, Victoria N. Parikh, Elizabeth T. Chin, Ayca Erbilgin, Michael J. Gloudemans, Ching Shang, Yong Huang, Alex C. Chang, Kevin S. Smith, Frederick Dewey, Kathia Zaleta, Michael Morley, Jeff Brandimarto, Nicole Glazer, Daryl Waggott, Aleksandra Pavlovic, Mingming Zhao, Christine S. Moravec, W. H. Wilson Tang, Jamie Skreen, Christine Malloy, Sridhar Hannenhalli, Hongzhe Li, Scott Ritter, Mingyao Li, Daniel Bernstein, Andrew Connolly, Hakon Hakonarson, Aldons J. Lusis, Kenneth B. Margulies, Anna A. Depaoli-Roach, Stephen B. Montgomery, Matthew T. Wheeler, Thomas Cappola, Euan A. Ashley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network anal
Externí odkaz:
https://doaj.org/article/2ca5a8edf42d48a4acecfce1aa70adac
Autor:
Christine P’ng, Jeffrey Green, Lauren C. Chong, Daryl Waggott, Stephenie D. Prokopec, Mehrdad Shamsi, Francis Nguyen, Denise Y. F. Mak, Felix Lam, Marco A. Albuquerque, Ying Wu, Esther H. Jung, Maud H. W. Starmans, Michelle A. Chan-Seng-Yue, Cindy Q. Yao, Bianca Liang, Emilie Lalonde, Syed Haider, Nicole A. Simone, Dorota Sendorek, Kenneth C. Chu, Nathalie C. Moon, Natalie S. Fox, Michal R. Grzadkowski, Nicholas J. Harding, Clement Fung, Amanda R. Murdoch, Kathleen E. Houlahan, Jianxin Wang, David R. Garcia, Richard de Borja, Ren X. Sun, Xihui Lin, Gregory M. Chen, Aileen Lu, Yu-Jia Shiah, Amin Zia, Ryan Kearns, Paul C. Boutros
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-5 (2019)
Abstract Background We introduce BPG, a framework for generating publication-quality, highly-customizable plots in the R statistical environment. Results This open-source package includes multiple methods of displaying high-dimensional datasets and f
Externí odkaz:
https://doaj.org/article/4314e3a47df049aeb55750230ad05c88
Autor:
Anna Shcherbina, MS, Steven G Hershman, PhD, Laura Lazzeroni, ProfPhD, Abby C King, ProfPhD, Jack W O'Sullivan, MBBS, Eric Hekler, PhD, Yasbanoo Moayedi, MD, Aleksandra Pavlovic, BS, Daryl Waggott, MSc, Abhinav Sharma, MD, Alan Yeung, MD, Jeffrey W Christle, PhD, Matthew T Wheeler, MD, Michael V McConnell, MD, Robert A Harrington, ProfMD, Euan A Ashley, ProfMBChB
Publikováno v:
The Lancet: Digital Health, Vol 1, Iss 7, Pp e344-e352 (2019)
Summary: Background: Smartphone apps might enable interventions to increase physical activity, but few randomised trials testing this hypothesis have been done. The MyHeart Counts Cardiovascular Health Study is a longitudinal smartphone-based study w
Externí odkaz:
https://doaj.org/article/aceeb023bce34d509b084c84d5f19183
Autor:
Emmi Tikkanen, Stefan Gustafsson, David Amar, Anna Shcherbina, Daryl Waggott, Euan A. Ashley, Erik Ingelsson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on several health indicators. In our di
Externí odkaz:
https://doaj.org/article/3bf66095c61b4c51a9330c0ef93d28da
Autor:
James R Priest, Kazutoyo Osoegawa, Nebil Mohammed, Vivek Nanda, Ramendra Kundu, Kathleen Schultz, Edward J Lammer, Santhosh Girirajan, Todd Scheetz, Daryl Waggott, Francois Haddad, Sushma Reddy, Daniel Bernstein, Trudy Burns, Jeffrey D Steimle, Xinan H Yang, Ivan P Moskowitz, Matthew Hurles, Richard P Lifton, Debbie Nickerson, Michael Bamshad, Evan E Eichler, Seema Mital, Val Sheffield, Thomas Quertermous, Bruce D Gelb, Michael Portman, Euan A Ashley
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005963 (2016)
Congenital heart disease (CHD) has a complex genetic etiology, and recent studies suggest that high penetrance de novo mutations may account for only a small fraction of disease. In a multi-institutional cohort surveyed by exome sequencing, combining
Externí odkaz:
https://doaj.org/article/897b1c0c4e4048629f49fa89a99239df
Autor:
Frederick E Dewey, Megan E Grove, James R Priest, Daryl Waggott, Prag Batra, Clint L Miller, Matthew Wheeler, Amin Zia, Cuiping Pan, Konrad J Karzcewski, Christina Miyake, Michelle Whirl-Carrillo, Teri E Klein, Somalee Datta, Russ B Altman, Michael Snyder, Thomas Quertermous, Euan A Ashley
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005496 (2015)
High throughput sequencing has facilitated a precipitous drop in the cost of genomic sequencing, prompting predictions of a revolution in medicine via genetic personalization of diagnostic and therapeutic strategies. There are significant barriers to
Externí odkaz:
https://doaj.org/article/70ddbbef50964fa686f86afd2fc73407
Autor:
Christine How, Melania Pintilie, Jeff P Bruce, Angela B Y Hui, Blaise A Clarke, Philip Wong, Shaoming Yin, Rui Yan, Daryl Waggott, Paul C Boutros, Anthony Fyles, David W Hedley, Richard P Hill, Michael Milosevic, Fei-Fei Liu
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123946 (2015)
Cervical cancer remains the third most frequently diagnosed and fourth leading cause of cancer death in women worldwide. We sought to develop a micro-RNA signature that was prognostic for disease-free survival, which could potentially allow tailoring
Externí odkaz:
https://doaj.org/article/1235328c0ddf4c9db04946a98098c460
Autor:
Anthony C. Nichols, Michelle Chan-Seng-Yue, John Yoo, Sumit K. Agrawal, Maud H. W. Starmans, Daryl Waggott, Nicholas J. Harding, Samuel A. Dowthwaite, David A. Palma, Kevin Fung, Bret Wehrli, S. Danielle MacNeil, Philippe Lambin, Eric Winquist, James Koropatnick, Joe S. Mymryk, Paul C. Boutros, John W. Barrett
Publikováno v:
Case Reports in Oncological Medicine, Vol 2013 (2013)
We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53.
Externí odkaz:
https://doaj.org/article/de7a2f8b41824da7836d5428cffab371
Autor:
Niina Sandholm, Rany M Salem, Amy Jayne McKnight, Eoin P Brennan, Carol Forsblom, Tamara Isakova, Gareth J McKay, Winfred W Williams, Denise M Sadlier, Ville-Petteri Mäkinen, Elizabeth J Swan, Cameron Palmer, Andrew P Boright, Emma Ahlqvist, Harshal A Deshmukh, Benjamin J Keller, Huateng Huang, Aila J Ahola, Emma Fagerholm, Daniel Gordin, Valma Harjutsalo, Bing He, Outi Heikkilä, Kustaa Hietala, Janne Kytö, Päivi Lahermo, Markku Lehto, Raija Lithovius, Anne-May Osterholm, Maija Parkkonen, Janne Pitkäniemi, Milla Rosengård-Bärlund, Markku Saraheimo, Cinzia Sarti, Jenny Söderlund, Aino Soro-Paavonen, Anna Syreeni, Lena M Thorn, Heikki Tikkanen, Nina Tolonen, Karl Tryggvason, Jaakko Tuomilehto, Johan Wadén, Geoffrey V Gill, Sarah Prior, Candace Guiducci, Daniel B Mirel, Andrew Taylor, S Mohsen Hosseini, DCCT/EDIC Research Group, Hans-Henrik Parving, Peter Rossing, Lise Tarnow, Claes Ladenvall, François Alhenc-Gelas, Pierre Lefebvre, Vincent Rigalleau, Ronan Roussel, David-Alexandre Tregouet, Anna Maestroni, Silvia Maestroni, Henrik Falhammar, Tianwei Gu, Anna Möllsten, Danut Cimponeriu, Mihai Ioana, Maria Mota, Eugen Mota, Cristian Serafinceanu, Monica Stavarachi, Robert L Hanson, Robert G Nelson, Matthias Kretzler, Helen M Colhoun, Nicolae Mircea Panduru, Harvest F Gu, Kerstin Brismar, Gianpaolo Zerbini, Samy Hadjadj, Michel Marre, Leif Groop, Maria Lajer, Shelley B Bull, Daryl Waggott, Andrew D Paterson, David A Savage, Stephen C Bain, Finian Martin, Joel N Hirschhorn, Catherine Godson, Jose C Florez, Per-Henrik Groop, Alexander P Maxwell
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002921 (2012)
Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality
Externí odkaz:
https://doaj.org/article/818e5a61debb4667aafbe14358bd9b2a
Autor:
Ilja M Nolte, Chris Wallace, Stephen J Newhouse, Daryl Waggott, Jingyuan Fu, Nicole Soranzo, Rhian Gwilliam, Panos Deloukas, Irina Savelieva, Dongling Zheng, Chrysoula Dalageorgou, Martin Farrall, Nilesh J Samani, John Connell, Morris Brown, Anna Dominiczak, Mark Lathrop, Eleftheria Zeggini, Louise V Wain, Wellcome Trust Case Control Consortium, DCCT/EDIC Research Group, Christopher Newton-Cheh, Mark Eijgelsheim, Kenneth Rice, Paul I W de Bakker, QTGEN consortium, Arne Pfeufer, Serena Sanna, Dan E Arking, QTSCD consortium, Folkert W Asselbergs, Tim D Spector, Nicholas D Carter, Steve Jeffery, Martin Tobin, Mark Caulfield, Harold Snieder, Andrew D Paterson, Patricia B Munroe, Yalda Jamshidi
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6138 (2009)
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS
Externí odkaz:
https://doaj.org/article/a075bafac4a04e268a97868576cece99