Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Daryl Shanley"'
Autor:
Nicola Fullard, James Wordsworth, Ciaran Welsh, Victoria Maltman, Charlie Bascom, Ryan Tasseff, Robert Isfort, Lydia Costello, Rebekah-Louise Scanlan, Stefan Przyborski, Daryl Shanley
Publikováno v:
Cells, Vol 13, Iss 8, p 659 (2024)
Skin ageing is defined, in part, by collagen depletion and fragmentation that leads to a loss of mechanical tension. This is currently believed to reflect, in part, the accumulation of senescent cells. We compared the expression of genes and proteins
Externí odkaz:
https://doaj.org/article/dc01f4ce86bc4473a783558f5164fe8f
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55190 (2013)
The presence of DNA double-stranded breaks in a mammalian cell typically activates the Non-Homologous End Joining (NHEJ) pathway to repair the damage and signal to downstream systems that govern cellular decisions such as apoptosis or senescence. The
Externí odkaz:
https://doaj.org/article/d5b4ba74bf394007a98fe443a502d4d6
Autor:
Conor Lawless, Diana Jurk, Colin S Gillespie, Daryl Shanley, Gabriele Saretzki, Thomas von Zglinicki, João F Passos
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32117 (2012)
Increases in cellular Reactive Oxygen Species (ROS) concentration with age have been observed repeatedly in mammalian tissues. Concomitant increases in the proportion of replicatively senescent cells in ageing mammalian tissues have also been observe
Externí odkaz:
https://doaj.org/article/1da9c1db86c8410ebf20ad1c829a70db
Autor:
Daniel Charles Green, Louise Reynard, James Henstock, Sjur Reppe, Kaare Gutvik, Mandy Peffers, Daryl Shanley, Peter Clegg, Elizabeth Canty-Laird
BackgroundAge is a significant risk factor for functional decline and disease of the musculoskeletal system, yet few biomarkers exist to facilitate ageing research in musculoskeletal tissues. Multivariate models based on DNA methylation, termed epige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f83c9ec21b21061a16873af39b5d143
https://doi.org/10.1101/2023.05.04.539347
https://doi.org/10.1101/2023.05.04.539347
Skin ageing has been widely associated with the formation and presence of increasing quantities of senescent cells, the presence of which are thought to reduce cell renewal. This study aimed to identify key factors influencing fibroblast and skin agi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370a70d048149f7cf4651fffb05c58e7
https://doi.org/10.1101/2022.08.16.504111
https://doi.org/10.1101/2022.08.16.504111
Skin ageing has been widely associated with the formation and presence of increasing quantities of senescent cells, the presence of which are thought to reduce cell renewal. This study aimed to identify key factors influencing fibroblast and skin agi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5a3867e01d30d18ddda7772ba0d7f5b
https://doi.org/10.1101/2022.08.16.504102
https://doi.org/10.1101/2022.08.16.504102
Publikováno v:
Mechanisms of ageing and development. 207
Ageing is currently believed to reflect the accumulation of molecular damage due to energetic costs of maintenance, as proposed in disposable soma theory (DST). Here we use agent-based modelling to describe an alternative theory by which ageing could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0bb0529a5aa419ac6e08e969e456ee
https://pubmed.ncbi.nlm.nih.gov/35868541
https://pubmed.ncbi.nlm.nih.gov/35868541