Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Daryl S. Fair"'
Publikováno v:
European Respiratory Journal. 8:2038-2045
Extravascular fibrin deposition characterizes diverse forms of lung and pleural injury. Fibrin formation in these compartments is locally potentiated by the assembly and expression of the prothrombinase procoagulant complex (factors Xa, Va and II) at
Autor:
Daryl S. Fair, Anuradha Kumar
Publikováno v:
European Journal of Biochemistry. 217:509-518
Factor VII, a serine-protease zymogen, and tissue factor, the cellular receptor/coenzyme, are the protein components of the macromolecular complex which initiates the extrinsic pathway of the coagulation cascade. Previous studies were directed to the
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1172:301-305
This study addresses whether a mutation in the factor VIIPadua gene could explain the reduced activity of the inherited variant protein. All nine exons of the normal and Padua factor VII gene were amplified using the polymerase chain reaction, cloned
Publikováno v:
American Review of Respiratory Disease. 144:187-194
The potential importance of pleural fibrin deposition in the pathogenesis of pleural injury is supported by both clinical and experimental observations. We hypothesized that the local equilibrium between procoagulant and fibrinolytic activities is di
Publikováno v:
Blood. 77:317-323
ACTOR X IS A SERINE protease zymogen that plays F a pivotal role in blood coagulation.’ It can be activated physiologically by the extrinsic (factor VIIa/tissue factor complex) and intrinsic (factor IXa/factor VIIIa complex) pathways in the presenc
Autor:
Dario C. Altieri, Thomas S. Edgington, Terence K. Brunck, John E. Geltosky, David P. Hajjar, Daryl S. Fair, Orli R. Etingin
Publikováno v:
Science. 254:1200-1202
Three spatially distant surface loops were found to mediate the interaction of the coagulation protein factor X with the leukocyte integrin Mac-1. This interacting region, which by computational modeling defines a three-dimensional macromotif in the
Autor:
Allen B. Cohen, William Girard, Jerry McLarty, Barry Starcher, Michael Stevens, Daryl S. Fair, Doris Davis, Harold James, Joel Rosenbloom, Umberto Kucich
Publikováno v:
The American review of respiratory disease. 142(1)
Current data suggest that emphysema in smokers is caused at least in part by the unrestrained action of neutrophil elastase on pulmonary tissues. Since colchicine reduces the secretion of enzymes from stimulated neutrophils, we designed a clinical tr
Autor:
Thomas S. Edgington, George A. Ricca, Richard Howk, Daryl S. Fair, Bruce R. Bahnak, Michael C. Jaye, James H. Morrissey, William Drohan
Publikováno v:
Blood. 69:224-230
In order to examine the control of human factor X biosynthesis we have molecularly cloned the cDNA and investigated the expression of the Factor X gene. A recombinant clone of approximately 1100 base pairs in length containing the sequence of factor
Publikováno v:
The Journal of Immunology. 117:944-949
Patient CM, who initially was diagnosed as having macroglobulinemia (IgM, κ) was subsequently found to develop a monoclonal IgA(κ) protein. Rabbit antisera directed against the patient's IgAm and IgM were rendered specific for individual antigenic
Publikováno v:
Cellular Immunology. 38:388-402
Molecules with LT activity which can be identified in supernatants from PHA stimulated human lymphocytes by lysis of murine L-929 cell in vitro are heterogeneous. They can be separated by MW on sephadex or ultrogel columns into four separate classes: