Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Daryl S. Walter"'
Autor:
Simon E. Ward, Jonathan M. Elkins, Daryl S. Walter, Roberta Regina Ruela de Sousa, P.H.C. Godoi, Oleg Fedorov, Scott H. Henderson, Jim Bennett, Sean W. Robinson, Iva Navratilova, Marcus T. Hanley, Alexander Ashall-Kelly, Fiona J. Sorrell
Publikováno v:
Journal of Medicinal Chemistry
Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) regulates the proliferation and differentiation of neuronal progenitor cells during brain development. Consequently, DYRK1A has attracted interest as a target for the treatment of neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2bf22a9a4b92dea834bf42e29260f1
http://europepmc.org/articles/PMC8482766
http://europepmc.org/articles/PMC8482766
Autor:
Thomas M. Zollner, Antonius Ter Laak, Daryl S. Walter, Jens Nagel, Anne-Marie Coelho, Horst Irlbacher, Michaele Peters, Andrea Rotgeri, Marcus Koppitz, Andreas Steinmeyer, Nico Bräuer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2700-2705
Here we report on novel and potent pyridyl-cycloalkyl-carboxylic acid inhibitors of microsomal prostaglandin E synthase-1 (PTGES). PTGES produces, as part of the prostaglandin pathway, prostaglandin E2 which is a well-known driver for pain and inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96084e274cca1ae051e390fee4a558ac
https://doi.org/10.1016/j.bmcl.2019.07.007
https://doi.org/10.1016/j.bmcl.2019.07.007
Autor:
Michael J. Tucker, Timothy J. Donohoe, Ahria Esphandiar Roushanbakhti, Wasim M. Akhtar, Yifan Liu, Daryl S. Walter, Gail L. Wrigley, Paul C. M. Winship
Publikováno v:
Angewandte Chemie International Edition. 56:14883-14887
Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt- or osmium-based) allowed for the formation of THF rings wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c7a0a05f89bf010bf36bb67dcb8e30
https://doi.org/10.1002/anie.201708278
https://doi.org/10.1002/anie.201708278
Autor:
Stefan Bäurle, Olaf Peters, Gernot Langer, Ludwig Zorn, Antonius Ter Laak, Nico Bräuer, Ulrich Bothe, Daryl S. Walter, Jens Nagel, Thomas M. Zollner, Thorsten Blume, Cornelia Preusse, Antje Rottmann, Andreas Steinmeyer, Dieter Heldmann
Publikováno v:
Journal of medicinal chemistry. 62(5)
The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes-the latter being frequently associated with severe, acute, and chronic pelvic pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e5e05b956c3b01375f513a8d2d40bc
https://pubmed.ncbi.nlm.nih.gov/30707023
https://pubmed.ncbi.nlm.nih.gov/30707023
Autor:
Thelma R. Cowley, Niamh Murphy, Daryl S. Walter, Marina A. Lynch, David Virley, Neil Upton, Jill C. Richardson
Publikováno v:
Brain Pathology. 22:295-306
Release of interleukin (IL)-1β from immunocompetent cells requires formation of the NACHT, LLR and PYD domains-containing protein 3 (NLRP3) inflammasome and caspase 1 activation. Adenosine 5'-triphosphate (ATP), acting on the P2X(7) receptor, is one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e33ac9cf76c9f76adc2fc66b5b0f5e7
https://doi.org/10.1111/j.1750-3639.2011.00531.x
https://doi.org/10.1111/j.1750-3639.2011.00531.x
Publikováno v:
Chemistry - An Asian Journal. 6:3214-3222
A new strategy that employs an exocyclic stereocenter to effect diastereocontrol in the tethered aminohydroxylation (TA) reaction is applied to the stereoselective synthesis of a range of amino alcohols in good to excellent yields, and with anti sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47a45a1db68980c9972f889ec396252
https://doi.org/10.1002/asia.201100497
https://doi.org/10.1002/asia.201100497
Autor:
Andrew Charlton, Stephen J. Medhurst, Laura J. Chambers, Livermore David, Brian Peter Slingsby, Andy Billinton, Lee William Page, Anton D. Michel, Daryl S. Walter, Jon Graham Anthony Steadman, Shilina Roman, Sadhana Patel, Elena Fonfria, Robert Gleave, Stefan Senger, Katharine Laura Collis, Andrew P. Moses, Sue D. Collins, Muna H. Abdi, Paul John Beswick, Clarisse L. Lejeune, David Kenneth Dean, Alexander J. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5080-5084
A computational lead-hopping exercise identified compound 4 as a structurally distinct P2X(7) receptor antagonist. Structure-activity relationships (SAR) of a series of pyroglutamic acid amide analogues of 4 were investigated and compound 31 was iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3ff37009bb76b9bfd50c27c623c06d
https://doi.org/10.1016/j.bmcl.2010.07.033
https://doi.org/10.1016/j.bmcl.2010.07.033
Autor:
Alan Naylor, Emmanuel Hubert Demont, P. Theobald, Daryl S. Walter, G. Maile, Gareth Wayne, Ishrut Hussain, Colin Dingwall, B. Clarke, C. Howes, Sharon Sweitzer, D. Vesey, Leanne Cutler, Julie Hawkins, Rosalie Matico, J. Mosley, A. O'Brien, Virginie Soleil, Sally Redshaw, Kathrine J. Smith, Paul Rowland, R. Dunsdon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4639-4644
Inhibition of the aspartyl protease BACE-1 has the potential to deliver a disease-modifying therapy for Alzheimer's disease. Herein, is described a series of potent inhibitors based on an hydroxyethylamine (HEA) transition state mimetic template. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851f861c6b32aae4d35275a238821e3a
https://doi.org/10.1016/j.bmcl.2010.05.111
https://doi.org/10.1016/j.bmcl.2010.05.111
Autor:
Sac-Pham Tang, Robert Gleave, Paul John Beswick, Anton D. Michel, Shilina Roman, Daryl S. Walter, Elena Fonfria
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4951-4954
A series of analogues of the pyrazole lead 1 were synthesized in which the heterocyclic core was replaced with an imidazole. A number of potent antagonists were identified and structure-activity relationships (SAR) were investigated both with respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd3c3bca3e3b25d838ba76c348b646e
https://doi.org/10.1016/j.bmcl.2010.05.018
https://doi.org/10.1016/j.bmcl.2010.05.018
Autor:
Andy Billinton, Sue Roomans, Stefan Senger, Anton D. Michel, Stephen J. Medhurst, Robert Gleave, Daryl S. Walter, Elena Fonfria, Laura J. Chambers, Andrew P. Moses, Shilina Roman, David Kenneth Dean, Alexander J. Stevens, Paul John Beswick, Sadhana Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4653-4656
Structure–activity relationships (SAR) of analogues of lead compound 1 were investigated and compound 16 was selected for further study in animal models of pain. Compound 16 was shown to be a potent antihyperalgesic agent in both the rat acute comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05399c19e1a56ae550e1d9ced9f9a3a
https://doi.org/10.1016/j.bmcl.2010.05.107
https://doi.org/10.1016/j.bmcl.2010.05.107