Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Daryl K. Granner"'
Publikováno v:
Molecular Endocrinology. 21:550-563
Insulin represses gluconeogenesis, in part, by inhibiting the transcription of genes that encode rate-determining enzymes, such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase). Glucocorticoids stimulate expression of
Publikováno v:
Advances in experimental medicine and biology. 872
The history of glucocorticoid hormone research is an excellent example of "bedside to bench" investigation. It started with two very insightful clinical observations. Thomas Addison described the syndrome of what came to be known as adrenal hormone i
Autor:
Daryl K. Granner
If you don't know where you're going, you might wind up someplace else—Yogi Berra My professional journey, once I accepted the fact that I would not play first base for the Chicago Cubs, was not accomplished in a straight line. I entered medical sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f7ee7fb38d88acd10c73fb0e8be6bc
https://europepmc.org/articles/PMC4566208/
https://europepmc.org/articles/PMC4566208/
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781493928941
The history of glucocorticoid hormone research is an excellent example of "bedside to bench" investigation. It started with two very insightful clinical observations. Thomas Addison described the syndrome of what came to be known as adrenal hormone i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62613be12cb6e59ea76603f727940e7e
https://doi.org/10.1007/978-1-4939-2895-8_1
https://doi.org/10.1007/978-1-4939-2895-8_1
Autor:
Joseph M. Beechem, Wieb Van Der Meer, Alvin C. Powers, Daryl K. Granner, Richard R. Whitesell, Hossein Ardehali, Laureta M. Perriott
Publikováno v:
Biochemical Journal. 386:245-253
The first steps of glucose metabolism are carried out by members of the families of GLUTs (glucose transporters) and HKs (hexokinases). Previous experiments using the inhibitor of glucose transport, CB (cytochalasin B), revealed that compartmentaliza
Autor:
Daryl K. Granner, R. Richard Pencek, Carlo M. Malabanan, Patrick T. Fueger, David H. Wasserman, Deanna P. Bracy
Publikováno v:
Diabetes. 53:306-314
The aim of the present study was to determine the specific sites of impairment to muscle glucose uptake (MGU) in the insulin-resistant high-fat-fed, conscious C57BL/6J mouse. Wild type (WT) and hexokinase II overexpressing (HK(Tg)) mice were fed eith
Autor:
Marc C. Daniels, Birger Herzog, Xiaohui L. Wang, Ratna Prasad, Daryl K. Granner, David T. Duong, Mary Waltner-Law
Publikováno v:
Journal of Biological Chemistry. 278:10427-10435
Although many genes are regulated by the concerted action of several hormones, hormonal signaling to gene promoters has generally been studied one hormone at a time. The phosphoenolpyruvate carboxykinase (PEPCK) gene is a case in point. Transcription
Autor:
Mary Waltner-Law, Masao Nawano, Robert K. Hall, Brian K. Law, Daryl K. Granner, Xiaohui L. Wang
Publikováno v:
Journal of Biological Chemistry. 277:34933-34940
Herbs have been used for medicinal purposes, including the treatment of diabetes, for centuries. Plants containing flavonoids are used to treat diabetes in Indian medicine and the green tea flavonoid, epigallocatechin gallate (EGCG), is reported to h
Publikováno v:
Journal of Biological Chemistry. 277:32234-32242
Hormones regulate glucose homeostasis, in part, by controlling the expression of gluconeogenic enzymes, such as phosphoenolpyruvate carboxykinase (PEPCK). Insulin and glucocorticoids reciprocally regulate PEPCK expression primarily at the level of ge
Publikováno v:
Journal of Biological Chemistry. 277:26098-26102
Glucocorticoids cause a 10-fold increase in hepatic phosphoenolpyruvate carboxykinase (PEPCK) gene transcription through two low affinity glucocorticoid receptor (GR) binding sites and a complex array of accessory factor DNA elements and associated p