Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Daryl E. Klein"'
Autor:
Marcelo Perez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón
Publikováno v:
Science advances, vol 9, iss 19
A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcriptional elongat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e0218b4be08840a5f27959c9739f5f
https://escholarship.org/uc/item/772881jj
https://escholarship.org/uc/item/772881jj
Autor:
Jianan Zhang, Daryl E. Klein, Yueyue Wang, S.E. Stayrook, Ian X. Walker, Olivia Belliveau, Irit Lax, Andrew Proffitt, Krishna C. Mudumbi, Mansoor Ahmed, Diego Alvarado, Hengyi Li, Mark A. Lemmon, Yoshihisa Suzuki, S.G. Krimmer, Tongqing Li, Joseph Schlessinger, Yuko Tsutsui
Publikováno v:
Nature
The proto-oncogene ALK encodes anaplastic lymphoma kinase, a receptor tyrosine kinase that is expressed primarily in the developing nervous system. After development, ALK activity is associated with learning and memory1 and controls energy expenditur
Autor:
Marcelo Perez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón
A fundamental facet of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcription elongation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66d1f2768dd41bf340dfd25175ff65c
https://doi.org/10.1101/2022.10.17.512631
https://doi.org/10.1101/2022.10.17.512631
Autor:
Jorge D. Martin-Rufino, Nicole Castano, Michael Pang, Emanuelle I. Grody, Samantha Joubran, Alexis Caulier, Lara Wahlster, Tongqing Li, Xiaojie Qiu, Anna Maria Riera-Escandell, Gregory A. Newby, Aziz Al’Khafaji, Santosh Chaudhary, Susan Black, Chen Weng, Glen Munson, David R. Liu, Marcin W. Wlodarski, Kacie Sims, Jamie H. Oakley, Ross M. Fasano, Ramnik J. Xavier, Eric S. Lander, Daryl E. Klein, Vijay G. Sankaran
Publikováno v:
Cell. 186:2456-2474.e24
Autor:
Alan B. Cantor, Inga Hofmann, Vijay G. Sankaran, David A. Williams, Dilnar Mahmut, Mitsutoshi Nakamura, Amy E. Geddis, Nour J. Abdulhay, Susan M. Parkhurst, Jeffrey M. Verboon, Becky Manes, Haydar Frangoul, Stacey Gabriel, Ah Ram Kim, Genevieve M. Crane, Daryl E. Klein, Thomas E. Akie, Namrata Gupta, Meghan E. Kapp, Satish K. Nandakumar
Publikováno v:
Journal of Clinical Immunology
Studies of genetic blood disorders have advanced our understanding of the intrinsic regulation of hematopoiesis. However, such genetic studies have only yielded limited insights into how interactions between hematopoietic cells and their microenviron
Publikováno v:
eLife, Vol 4 (2015)
Externí odkaz:
https://doaj.org/article/435b0aecc0fb45f281922d28cd3b9b12
Publikováno v:
eLife, Vol 3 (2014)
The West Nile Virus (WNV) envelope protein, E, promotes membrane fusion during viral cell entry by undergoing a low-pH triggered conformational reorganization. We have examined the mechanism of WNV fusion and sought evidence for potential intermediat
Externí odkaz:
https://doaj.org/article/441362c52b10468da9834fe24f8ceae2
Publikováno v:
Sci Signal
In responses to activation of receptor tyrosine kinases (RTKs), crucial cell fate decisions depend on the duration and dynamics of ERK signaling. In PC12 cells, epidermal growth factor (EGF) induces transient ERK activation that leads to cell prolife
Autor:
Connor A. Emdin, Mark J. Daly, Aki S. Havulinna, Aitzkoa Lopez de Lapuente Portilla, Saiju Pyarajan, Christopher P. Nelson, Pradeep Natarajan, Bo Li, Tuomo Kiiskinen, Benjamin M. Neale, Aviv Regev, John E. Dick, Christopher J. Walker, Marcin Tabaka, Xiaotian Liao, Juha Karjalainen, Aarno Palotie, Claire Churchhouse, Christopher J. O'Donnell, Daryl E. Klein, Peter W.F. Wilson, Michael Milyavsky, Vijay G. Sankaran, Albert de la Chapelle, Olga I. Gan, Caleb A. Lareau, Alexander G. Bick, Björn Nilsson, Erik L. Bao, Nilesh J. Samani, Satish K. Nandakumar, Veryan Codd, J. Michael Gaziano, Sekar Kathiresan, Kelly Cho
Publikováno v:
Nature
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies i
Publikováno v:
Journal of Virology. 87:2287-2293
The final stages of dengue virus fusion are thought to occur when the membrane-proximal stem drives the transmembrane anchor of the viral envelope protein (E) toward the fusion loop, buried in the target cell membrane. Crystal structures of E have la