Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks

Autor: Sam P. Nayler, Joseph E. Powell, Darya P. Vanichkina, Othmar Korn, Christine A. Wells, Refik Kanjhan, Jian Sun, Ryan J. Taft, Martin F. Lavin, Ernst J. Wolvetang

Publikováno v: Frontiers in Cellular Neuroscience, Vol 11 (2017)

Ataxia-telangiectasia (A-T) is a rare genetic disorder caused by loss of function of the ataxia-telangiectasia-mutated kinase and is characterized by a predisposition to cancer, pulmonary disease, immune deficiency and progressive degeneration of the

Externí odkaz: https://doaj.org/article/17a53e9a51964d62b225ea5908976ddc

Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner

Autor: Justin J.-L. Wong, Amy D. Marshall, Charles G. Bailey, Melissa Vellozzi, John E.J. Rasko, Ulf Schmitz, Darya P. Vanichkina, Adel B Alharbi, Rajini Nagarajah

Publikováno v: RNA Biology
article-version (VoR) Version of Record

CTCF is a master regulator of gene transcription and chromatin organization with occupancy at thousands of DNA target sites. CTCF is essential for embryonic development and somatic cell viability and has been characterized as a haploinsufficient tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476a178f6d38fa83a174ae5f1f136676
http://europepmc.org/articles/PMC7834090

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Autor: Anna Williams, Ana Mendanha Falcão, Darya P. Vanichkina, Mandy Meijer, Gonçalo Castelo-Branco, Sarah Jäkel, Samudyata, Eneritz Agirre, Sueli Marques, David van Bruggen, Charles ffrench-Constant, Elisa M. Floriddia, André Ortlieb Guerreiro-Cacais

Publikováno v: Mendanha Falcão, A, van Bruggen, D, Marques, S, Meijer, M, Jaekel, S, Agirre, E, Samudyata, Floriddia, E M, Vanichkina, D P, ffrench-Constant, C, Williams, A, Ortlieb Guerreiro-Cacais, A & Castelo-Branco, G 2018, ' Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis ', Nature Medicine, vol. 24, no. 12, pp. 1837–1844 . https://doi.org/10.1038/s41591-018-0236-y
Nature Medicine

Multiple sclerosis (MS) is characterized by an immune system attack targeting myelin, which is produced by oligodendrocytes (OLs). We performed single-cell transcriptomic analysis of OL lineage cells from the spinal cord of mice induced with experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93de6ec6146168779a3274b56d78789f
https://www.pure.ed.ac.uk/ws/files/76565091/accepted_smaller.pdf

RevSex duplication-induced and sex-related differences in theSOX9regulatory region chromatin landscape in human fibroblasts

Autor: Atle Brendehaug, Darya P. Vanichkina, Chirag Nepal, Helle Lybæk, Anke H A den Engelsman-van Dijk, Gunnar Houge, Diederik R.H. de Bruijn

Publikováno v: Epigenetics

It was recently shown that duplications of the RevSex element, located 0.5 Mb upstream of SOX9, cause XX-disorder of sex development (DSD), and that deletions cause XY-DSD. To explore how a 148 kb RevSex duplication could have turned on gonadal SOX9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c195e79914e9e5d09a2f3e33bbf170ab
https://doi.org/10.4161/epi.27474

Amiodarone induces cell wall channel formation in yeast Hansenula polymorpha

Autor: Sviatoslav S. Sokolov, Tatyana S. Kalebina, Fedor F. Severin, Darya P. Vanichkina, I.O. Selyakh

Publikováno v: SpringerPlus

The yeast cell wall is constantly remodeled to enable cell growth and division. In this study, we describe a novel type of cell wall modification. We report that the drug amiodarone induces rapid channel formation within the cell wall of the yeast Ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0b8725ce914cadc4cb3f53b1b61c93
https://doi.org/10.1186/s40064-015-1185-2