Technological advances for analyzing the content of organ-on-a-chip by mass spectrometry

Autor: Darya Hadavi, Ilona Tosheva, Tiffany Porta Siegel, Eva Cuypers, Maarten Honing

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Three-dimensional (3D) cell cultures, including organ-on-a-chip (OOC) devices, offer the possibility to mimic human physiology conditions better than 2D models. The organ-on-a-chip devices have a wide range of applications, including mechanical studi

Externí odkaz: https://doaj.org/article/c31bf685d83347849f5a4e0932c8f739

Ion mobility spectrometry-tandem mass spectrometry strategies for the on-line monitoring of a continuous microflow reaction

Autor: Peiliang Han, Darya Hadavi, Maarten Honing

Publikováno v: Journal of Flow Chemistry, 12(2), 175-184. Akademiai Kiado

Continuous flow chemistry is an efficient, sustainable and green approach for chemical synthesis that surpasses some of the limitations of the traditional batch chemistry. Along with the multiple advantages of a flow reactor, it could be directly con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa289ee33504f610b556b338c639a943
https://doi.org/10.1007/s41981-021-00209-7

Quantitative mass spectrometry imaging of drugs and metabolites

Autor: Bryn Flinders, Tiffany Porta Siegel, Darya Hadavi, Brent Viehmann, Rob J. Vreeken, Ron M. A. Heeren, Lieke Lamont

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, 413(10), 2779-2791. Springer

Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad range of compounds and, therefore, is frequently applied in the pharmaceutical industry. Pharmacokinetic and toxicological studies deploy MSI to localize pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee194af7c6a0d7bdf25669bb02920b4
https://doi.org/10.1007/s00216-021-03210-0

TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

Autor: Maarten Honing, Darya Hadavi, Matt Timmers, Tommi Meulemans, Jimmy Weterings, Rob M. J. Liskamp, Cristianne J.F. Rijcken, Harald Veldhuis, Hans Ippel

Publikováno v: Chemical Science
Chemical Science, 11(33), 9011-9016. Royal Society of Chemistry

We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b44ad190e51f2e421aa1784b987eb2
https://doi.org/10.1039/d0sc03477k

Synthesis and Catalytic Application of Knölker-Type Iron Complexes with a Novel Asymmetric Cyclopentadienone Ligand Design

Autor: Darya Hadavi, Khi Chhay Chou, Lukas Morick, Burgert Blom, Christian A. M. R. van Slagmaat, Stefaan M. A. De Wildeman

Publikováno v: Catalysts
Volume 9
Issue 10
Catalysts, Vol 9, Iss 10, p 790 (2019)
Catalysts, 9(10):790. Multidisciplinary Digital Publishing Institute (MDPI)

Asymmetric catalysis is an essential tool in modern chemistry, but increasing environmental concerns demand the development of new catalysts based on cheap, abundant, and less toxic iron. As a result, Knö
lker-type catalysts have emerged as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464695bb9c4c8599a10a16154eefe01a
https://doi.org/10.3390/catal9100790