Oxidative Glucose Metabolism Promotes Senescence in Vascular Endothelial Cells

Autor: Leonie K. Stabenow, Darya Zibrova, Claudia Ender, Dario L. Helbing, Katrin Spengler, Christian Marx, Zhao-Qi Wang, Regine Heller

Publikováno v: Cells, Vol 11, Iss 14, p 2213 (2022)

Vascular aging is based on the development of endothelial dysfunction, which is thought to be promoted by senescent cells accumulating in aged tissues and is possibly affected by their environment via inflammatory mediators and oxidative stress. Sene

Externí odkaz: https://doaj.org/article/4e79ea5e59b34386911a38e499fdd768

Hyperglycemia-induced endothelial dysfunction is alleviated by thioredoxin mimetic peptides through the restoration of VEGFR-2-induced responses and improved cell survival

Autor: Pia Hemling, Henny Schulten, Darya Zibrova, Johannes Waltenberger, Regine Heller, Hannes M. Findeisen, Gernot Desoye, Jasmin Strutz, Yahya Sohrabi, Rinesh Godfrey

Publikováno v: International Journal of Cardiology, 308, 73-81. Elsevier Ireland Ltd

BACKGROUND: Diabetes mellitus is an important cardiovascular risk factor characterized by elevated plasma glucose levels. High glucose (HG) negatively influences endothelial cell (EC) function, which is characterized by the inability of ECs to respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a652dcb7896a3c8f4d8cd7d87b806d57
https://doi.org/10.1016/j.ijcard.2019.12.065

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

Autor: Cora Weigert, Kei Sakamoto, Katrin Spengler, Mark Peggie, Karina Mariño, Olga Göransson, Franck Vandermoere, Anne Knierim, Darya Zibrova, Benoit Viollet, Nicholas A. Morrice, Regine Heller

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2017, 474 (6), pp.983-1001. ⟨10.1042/BCJ20160980⟩
Biochem. J. 474, 983-1001 (2017)

Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy homeostasis, stress protection and angiogenesis, but the underlying mechanisms are incompletely understood. Using a label-free phosphoproteomic analysis, we ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9cf91a6472ceb8ae0ea89dadd05423
https://hal.archives-ouvertes.fr/hal-02366087/document

Overexpression of FK-506–Binding Protein 12.0 Modulates Excitation–Contraction Coupling in Adult Rabbit Ventricular Cardiomyocytes

Autor: Nils Teucher, Godfrey L. Smith, Christopher M. Loughrey, Harald Kögler, Tim Seidler, Darya Zibrova, Sarah Kettlewell, Gerd Hasenfuss

Publikováno v: Circulation Research. 101:1020-1029

The effect of the 12-kDa isoform of FK-506–binding protein (FKBP)12.0 on cardiac excitation–contraction coupling was studied in adult rabbit ventricular myocytes after transfection with a recombinant adenovirus coding for human FKBP12.0 (Ad-FKBP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c47cac540e6c433d8609e6b77885e45
https://doi.org/10.1161/circresaha.107.154609

Increased Sarcoplasmic Reticulum Calcium Leak but Unaltered Contractility by Acute CaMKII Overexpression in Isolated Rabbit Cardiac Myocytes

Autor: Lu Chen, Lars S. Maier, Astrid Steen, Stefan Wagner, Nataliya Dybkova, Donald M. Bers, Tong Zhang, Joan Heller Brown, Tim Seidler, Darya Zibrova, Michael Kohlhaas

Publikováno v: Circulation Research. 98:235-244

The predominant cardiac Ca 2+ /calmodulin-dependent protein kinase (CaMK) is CaMKIIδ. Here we acutely overexpress CaMKIIδ C using adenovirus-mediated gene transfer in adult rabbit ventricular myocytes. This circumvents confounding adaptive effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ed9560947ff22208b7fc8e861db43b
https://doi.org/10.1161/01.res.0000200739.90811.9f