Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Darwin V. Lee"'
Autor:
Darwin V Lee, Dongmei Li, Qingyun Yan, Yimin Zhu, Bryan Goodwin, Roberto Calle, Martin B Brenner, Saswata Talukdar
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111767 (2014)
Fibroblast growth factor 21 (FGF21) has evolved as a major metabolic regulator, the pharmacological administration of which causes weight loss, insulin sensitivity and glucose control in rodents and humans. To understand the molecular mechanisms by w
Externí odkaz:
https://doaj.org/article/4bb2cb6254e341c3a8c89725072036b0
Autor:
Denise O'Hara, William S. Somers, Ron Kriz, Saswata Talukdar, Jeffrey R. Chabot, Eric Sousa, Annette Sievers, Alison Joyce, Yingjiang Zhou, Jie Guo, Barbara Bernardo, Dongmei Li, Craig Giragossian, Alison Logan, Amy Tam, Roberto A. Calle, Mania Kavosi, Tracey Clark, Laura Lin, Tetsuya Ishino, Darwin V. Lee, Weili Duan, Kelvin M. Kerns, Mark Stahl, Yan Weng, Tao He
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Pharmacological administration of FGF21 analogues has shown robust body weight reduction and lipid profile improvement in both dysmetabolic animal models and metabolic disease patients. Here we report the design, optimization, and characterization of
Autor:
Christian T. Carson, Darwin V. Lee, Jiri Lukas, Matthew D. Weitzman, Nicole I. Orazio, Seema S. Lakdawala, Caroline E. Lilley, Jiri Bartek, Junghae Suh, Felipe D. Araujo, Simon Bekker-Jensen
Publikováno v:
The EMBO Journal. 28:652-662
The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA
Autor:
Caroline E. Lilley, Darwin V. Lee, Hui Chen, Matthew D. Weitzman, Iñigo Narvaiza, Qin Yu, Jody Chou, Nathaniel R. Landau
Publikováno v:
Current Biology. 16:480-485
SummaryAPOBEC3 proteins constitute a family of cytidine deaminases that provide intracellular resistance to retrovirus replication and transposition of endogenous retroelements [1]. One family member, APOBEC3A (hA3A), is an orphan, without any known
Autor:
Travis H. Stracker, David A. Ornelles, Christian T. Carson, Darwin V. Lee, Matthew D. Weitzman, Felipe D. Araujo
Publikováno v:
Journal of Virology. 79:6664-6673
The early transcriptional region 4 (E4) of adenovirus type 5 (Ad5) encodes gene products that modulate splicing, apoptosis, transcription, DNA replication, and repair pathways. Viruses lacking both E4orf3 and E4orf6 have a severe replication defect,
Autor:
Yimin Zhu, Bryan Goodwin, Saswata Talukdar, Darwin V. Lee, Dongmei Li, Martin B. Brenner, Roberto A. Calle, Qingyun Yan
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111767 (2014)
PLoS ONE
PLoS ONE
Fibroblast growth factor 21 (FGF21) has evolved as a major metabolic regulator, the pharmacological administration of which causes weight loss, insulin sensitivity and glucose control in rodents and humans. To understand the molecular mechanisms by w
Autor:
Darwin V. Lee, Matthew D. Weitzman, Felipe D. Araujo, Travis H. Stracker, Christian T. Carson
Virus infections have dramatic effects on structural and morphological characteristics of the host cell. The gene product of open reading frame 3 in the early region 4 (E4orf3) of adenovirus serotype 5 (Ad5) is involved in efficient replication and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665116338dacfbff6ee7722157616edc
https://europepmc.org/articles/PMC1193610/
https://europepmc.org/articles/PMC1193610/
Autor:
Matthew D. Weitzman, Darwin V. Lee, Masakuni Kido, Patricia A. Thistlethwaite, Joseph E. Rabinowitz, R. Jude Samulski, Stuart W. Jamieson, Lingling Du
Recombinant cross-packaging of adeno-associated virus (AAV) genome of one serotype into other AAV serotypes has the potential to optimize tissue-specific gene transduction and expression in the heart. To evaluate the role of AAV1 to 5 virion shells o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0587e79f24b3367d5a344d5608d6e6
Autor:
Caroline E. Lilley, Travis H. Stracker, Matthew D. Weitzman, Christian T. Carson, Darwin V. Lee, Rachel A. Schwartz
Publikováno v:
The EMBO journal. 22(24)
The maintenance of genome integrity requires a rapid and specific response to many types of DNA damage. The conserved and related PI3-like protein kinases, ataxia-telangiectasia mutated (ATM) and ATM-Rad3-related (ATR), orchestrate signal transductio
Autor:
Christian T. Carson, Rachel A. Schwartz, Travis H. Stracker, Caroline E. Lilley, Darwin V. Lee, Matthew D. Weitzman
Publikováno v:
EMBO Journal; 12/15/2003, Vol. 22 Issue 24, p6610-6620, 11p