Zobrazeno 1 - 10
of 621
pro vyhledávání: '"Darwin J Prockop"'
Autor:
Dong-Ki Kim, Hosoon Choi, Hidetaka Nishida, Joo Youn Oh, Carl Gregory, Ryang Hwa Lee, Ji Min Yu, Jun Watanabe, Su Yeon An, Thomas J Bartosh, Darwin J Prockop
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147553 (2016)
TNF-α stimulated gene/protein 6 (TNFAIP6/TSG-6) is a multifunctional protein that has a number of potential therapeutic applications. Experiments and clinical trials with TSG-6, however, have been limited by the technical difficulties of producing t
Externí odkaz:
https://doaj.org/article/9536d575041a4a7c8e89df705a057308
Autor:
Harris E McFerrin, Scott D Olson, Miriam V Gutschow, Julie A Semon, Deborah E Sullivan, Darwin J Prockop
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105411 (2014)
There have been conflicting observations regarding the receptors utilized by human multipotent mesenchymal bone marrow stromal cells (hMSC) to adhere to endothelial cells (EC). To address the discrepancies, we performed experiments with cells prepare
Externí odkaz:
https://doaj.org/article/ab8cf8a50fb14ee6b99f0a4004841b3d
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10237 (2010)
The epithelial cell response to stress involves the transmission of signals between contiguous cells that can be visualized as a calcium wave. In some cell types, this wave is dependent on the release of extracellular trinucleotides from injured cell
Externí odkaz:
https://doaj.org/article/70932b219d5241f68c3eb8400e3f93c1
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9347 (2010)
BACKGROUND:Implantation of human multipotent stromal cells from bone marrow (hMSCs) into the dentate gyrus of the hippocampus of mice was previously shown to stimulate proliferation, migration and neural differentiation of endogenous neural stem cell
Externí odkaz:
https://doaj.org/article/b9d65dd8768e47b7ba0ac4acfddb2d3f
Autor:
Shih-Chieh Hung, Radhika R Pochampally, Shu-Ching Hsu, Cecelia Sanchez, Sy-Chi Chen, Jeffrey Spees, Darwin J Prockop
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e416 (2007)
The ability of stem/progenitor cells to migrate and engraft into host tissues is key to their potential use in gene and cell therapy. Among the cells of interest are the adherent cells from bone marrow, referred to as mesenchymal stem cells or multip
Externí odkaz:
https://doaj.org/article/dd568033ac5c4303a9a925fbbddc42a0
Autor:
Jun Watanabe, Ashok K. Shetty, Bharathi Hattiangady, Dong-Ki Kim, Jessica E. Foraker, Hidetaka Nishida, Darwin J. Prockop
Publikováno v:
Neurobiology of Disease, Vol 59, Iss , Pp 86-99 (2013)
Traumatic brain injury (TBI) causes multiple long-term defects including a loss of working memory that is frequently incapacitating. Administrations of mesenchymal stem/stromal cells (MSCs) previously produced beneficial effects in models of TBI as w
Externí odkaz:
https://doaj.org/article/3fc7a38e50a44355b8a7f9ce45d7dc93
Autor:
Chinnaswamy Tiruppathi, Darwin J. Prockop, Yoshikazu Tsukasaki, Joseph Farahany, Manish Mittal, Saroj Nepal, Asrar B. Malik, Jalees Rehman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Clearance of apoptotic neutrophils by alveolar macrophages (AMФs) is critical for the resolution of acute lung injury (ALI). Here, we demonstrated that induction of the M1 phenotype in MФs activates the transcription factor STAT6 and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979ae261b4351d012ed9fcd5687fa279
https://doi.org/10.1073/pnas.1821601116
https://doi.org/10.1073/pnas.1821601116
Autor:
Samuel F. Fulcher, Roxanne L. Reger, Hosoon Choi, Darwin J. Prockop, Casie Phillips, Joo Youn Oh, Luke B. Potts
Publikováno v:
Current Eye Research. 44:873-881
Purpose: To investigate the therapeutic efficacy of tumor necrosis factor (TNF)-α stimulated gene/protein 6 (TSG-6) in a rat model of corneal alkali injury. Methods: Corneal alkali injury was produced by placing an NaOH-soaked filter paper disk on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1b77d00ea7e3dc1385bde3a1c5e9ed
https://doi.org/10.1080/02713683.2019.1597893
https://doi.org/10.1080/02713683.2019.1597893
Autor:
Su-Chun Zhang, Bing Shuai, Sahithi Attaluri, Dinesh Upadhya, Darwin J. Prockop, Olagide W. Castro, Bharathi Hattiangady, Ashok K. Shetty, Yi Dong, Adrian Bates, Maheedhar Kodali
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This study provides evidence that human induced pluripotent stem cell (hiPSC)-derived medial ganglionic eminence (MGE) cell grafting into the hippocampus after status epilepticus can greatly reduce the frequency of spontaneous seizures i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d525b1e61f36173bf0265cb5f44fe78
https://doi.org/10.1073/pnas.1814185115
https://doi.org/10.1073/pnas.1814185115
Autor:
Dong Hyun Kim, Hyun Beom Song, Jong Woo Park, Mee Kum Kim, Se Yeon Park, Jung Hwa Ko, Joo Youn Oh, Chang Ho Yoon, Darwin J. Prockop, Ryang Hwa Lee, Jeong Hun Kim
Publikováno v:
Molecular Therapy. 26:162-172
The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis and lymphangiogenesis in the cornea, compromising transparency and visual acuity. Mesenchymal stem/stromal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1b2339b5ac8b15379b1d2b4d4acfbc
https://doi.org/10.1016/j.ymthe.2017.09.026
https://doi.org/10.1016/j.ymthe.2017.09.026