Zobrazeno 1 - 10
of 2 018
pro vyhledávání: '"Darwin J"'
Autor:
Cindy X. Zhang, Thomas M. Conrad, David Hermann, Melita A. Gordon, Eric Houpt, Pui‐Ying Iroh Tam, Khuzwayo C. Jere, Wilfred Nedi, Darwin J. Operario, Jacob Phulusa, Gerald V. Quinnan Jr, Leigh A. Sawyer, Lynn K. Barrett, Herbert Thole, Neema Toto, Wesley C. Van Voorhis, Samuel L. M. Arnold
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 410-423 (2024)
Abstract Oral drug absorption kinetics are usually established in populations with a properly functioning gastrointestinal tract. However, many diseases and therapeutics can alter gastrointestinal physiology and cause diarrhea. The extent of diarrhea
Externí odkaz:
https://doaj.org/article/eb41958c05d84d0fb5af26988b5b95cf
Autor:
James T Nyirenda, Marc Y R Henrion, Vita Nyasulu, Mike Msakwiza, Wilfred Nedi, Herbert Thole, Jacob Phulusa, Neema Toto, Khuzwayo C Jere, Alex Winter, Leigh A Sawyer, Thomas Conrad, Donnie Hebert, Crystal Chen, Wesley C Van Voorhis, Eric R Houpt, Pui-Ying Iroh Tam, Darwin J Operario
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0289929 (2023)
BackgroundCryptosporidium is a gastrointestinal pathogen that presents a serious opportunistic infection in immunocompromised individuals including those living with human immunodeficiency syndrome. The CRYPTOFAZ trial, previously published, was cond
Externí odkaz:
https://doaj.org/article/38b18d8b8bf54a09b41579535f57db9c
Autor:
Jie Liu, Na Liu, Sarah Thomas, Sidhartha Giri, Gagandeep Kang, Dilip Abraham, James A Platts-Mills, Eric R Houpt, Ira Praharaj, Jacqueline E Tate, Umesh D Parashar, Timothy L McMurry, Elizabeth T Rogawski McQuade, Jason M Mwenda, Adam L Cohen, Tomoka Nakamura, Darwin J Operario, Sébastien Antoni, Goitom Weldegebriel, Gloria Rey-Benito, Lucia H de Oliveira, Claudia Ortiz, Danni S Daniels, Dovile Videbaek, Simarjit Singh, Emmanuel Njambe, Mohamed Sharifuzzaman, Varja Grabovac, Batmunkh Nyambat, Josephine Logronio, George Armah, Francis E Dennis, Mapaseka L Seheri, Nokululeko Magagula, Jeffrey Mphahlele, Tulio M Fumian, Irene T A Maciel, Jose Paulo Gagliardi Leite, Matthew D Esona, Michael D Bowen, Elena Samoilovich, Galina Semeiko, Julie Bines, Hmwe H Kyu, Matthew Doxey, Fatima Serhan
Publikováno v:
BMJ Global Health, Vol 7, Iss 9 (2022)
Introduction Diarrhoea remains a leading cause of child morbidity and mortality. Systematically collected and analysed data on the aetiology of hospitalised diarrhoea in low-income and middle-income countries are needed to prioritise interventions.Me
Externí odkaz:
https://doaj.org/article/8c84e06af8fc4c08960582315c4d007b
Autor:
Alberto A. Amarilla, Julian D. J. Sng, Rhys Parry, Joshua M. Deerain, James R. Potter, Yin Xiang Setoh, Daniel J. Rawle, Thuy T. Le, Naphak Modhiran, Xiaohui Wang, Nias Y. G. Peng, Francisco J. Torres, Alyssa Pyke, Jessica J. Harrison, Morgan E. Freney, Benjamin Liang, Christopher L. D. McMillan, Stacey T. M. Cheung, Darwin J. Da Costa Guevara, Joshua M. Hardy, Mark Bettington, David A. Muller, Fasséli Coulibaly, Frederick Moore, Roy A. Hall, Paul R. Young, Jason M. Mackenzie, Jody Hobson-Peters, Andreas Suhrbier, Daniel Watterson, Alexander A. Khromykh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here the authors describe a simple reverse genetics method that relies on overlapping cDNA fragments for generation of positive-strand viruses including SARS-CoV-2 and characterize them in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/2d42390e6b6242feac70593cf3d675b1
Autor:
Kennedy Kassaza, Anna C. Long, Jennifer M. McDaniels, Mharlove Andre, Wasswa Fredrickson, Dan Nyehangane, Patrick Orikiriza, Darwin J. Operario, Joel Bazira, Juliet A. Mwanga-Amumpaire, Christopher C. Moore, Jennifer L. Guler, Yap Boum
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti-malarial treatment, studies across malaria-endemic countries have shown a range
Externí odkaz:
https://doaj.org/article/f152dc36a8e54087990ba77a54094ca6
Autor:
Andreea Waltmann, Elizabeth T. Rogawski McQuade, Jobiba Chinkhumba, Darwin J. Operario, Enala Mzembe, Megumi Itoh, Michael Kayange, Sydney M. Puerto-Meredith, Don P. Mathanga, Jonathan J. Juliano, Ian Carroll, Luther A. Bartelt, Julie R. Gutman, Steven R. Meshnick
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103871- (2022)
Summary: Background: Poor pregnancy and birth outcomes are common in sub-Saharan Africa and have complex aetiologies. Sulfadoxine-pyrimethamine (SP), given for intermittent preventive therapy of malaria in pregnancy (IPTp), is one of few existing int
Externí odkaz:
https://doaj.org/article/749c16e640664b18b4ff59cb2580b647
Autor:
Natalia Pacienza, Ryang Hwa Lee, Eun-Hye Bae, Dong-ki Kim, Qisong Liu, Darwin J. Prockop, Gustavo Yannarelli
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 67-76 (2019)
Extracellular vesicles (EVs) play key roles in cell biology and may provide new clinical diagnostics and therapies. However, it has proven difficult to develop protocols for their purification and characterization. One of the major barriers in the fi
Externí odkaz:
https://doaj.org/article/edf9fc30177047ae834b933eb1960fa5
Autor:
Nicholas Amoako, Samuel Duodu, Francis E. Dennis, Joseph H.K. Bonney, Kwaku P. Asante, Juliana Ameh, Lydia Mosi, Takaya Hayashi, Eudosia E. Agbosu, Deborah Pratt, Darwin J. Operario, Barry Fields, Jie Liu, Eric R. Houpt, George E. Armah, Justin Stoler, Gordon A. Awandare
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 8, Pp 1544-1547 (2018)
We report new molecular evidence of locally acquired dengue virus infections in Ghana. We detected dengue viral RNA among children with suspected malaria by using a multipathogen real-time PCR. Subsequent sequence analysis revealed a close relationsh
Externí odkaz:
https://doaj.org/article/adc96705b5bb432eb0df3f792a6e6895
Autor:
Taeko Shigemoto-Kuroda, Joo Youn Oh, Dong-ki Kim, Hyun Jeong Jeong, Se Yeon Park, Hyun Ju Lee, Jong Woo Park, Tae Wan Kim, Su Yeon An, Darwin J. Prockop, Ryang Hwa Lee
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1214-1225 (2017)
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1
Externí odkaz:
https://doaj.org/article/68ea6baba9b44d3a8caca75da6a377a8
Autor:
James A Platts-Mills, MD, Jie Liu, PhD, Elizabeth T Rogawski, PhD, Furqan Kabir, MSc, Paphavee Lertsethtakarn, PhD, Mery Siguas, BSc, Shaila S Khan, MSc, Ira Praharaj, MD, Arinao Murei, BSc, Rosemary Nshama, BSc, Buliga Mujaga, BSc, Alexandre Havt, PhD, Irene A Maciel, PhD, Timothy L McMurry, PhD, Darwin J Operario, PhD, Mami Taniuchi, PhD, Jean Gratz, MS, Suzanne E Stroup, MS, James H Roberts, Adil Kalam, MSc, Fatima Aziz, MSc, Shahida Qureshi, MSc, M Ohedul Islam, MSc, Pimmada Sakpaisal, MSc, Sasikorn Silapong, B BSc, Pablo P Yori, MPH, Revathi Rajendiran, MSc, Blossom Benny, MSc, Monica McGrath, ScD, Benjamin J J McCormick, DPhil, Jessica C Seidman, PhD, Dennis Lang, PhD, Michael Gottlieb, PhD, Richard L Guerrant, MD, Aldo A M Lima, ProfPhD, Jose Paulo Leite, PhD, Amidou Samie, PhD, Pascal O Bessong, ProfPhD, Nicola Page, PhD, Ladaporn Bodhidatta, MD, Carl Mason, MD, Sanjaya Shrestha, MD, Ireen Kiwelu, PhD, Estomih R Mduma, MPH, Najeeha T Iqbal, PhD, Zulfiqar A Bhutta, ProfPhD, Tahmeed Ahmed, ProfMBBS, Rashidul Haque, PhD, Gagandeep Kang, ProfMD, Margaret N Kosek, MD, Eric R Houpt, ProfMD, Angel Mendez Acosta, Rosa Rios de Burga, Cesar Banda Chavez, Julian Torres Flores, Maribel Paredes Olotegui, Silvia Rengifo Pinedo, Dixner Rengifo Trigoso, Angel Orbe Vasquez, Imran Ahmed, Didar Alam, Asad Ali, Muneera Rasheed, Sajid Soofi, Ali Turab, Aisha Yousafzai, Anita KM Zaidi, Binob Shrestha, Bishnu Bahadur Rayamajhi, Tor Strand, Geetha Ammu, Sudhir Babji, Anuradha Bose, Ajila T George, Dinesh Hariraju, M. Steffi Jennifer, Sushil John, Shiny Kaki, Priyadarshani Karunakaran, Beena Koshy, Robin P Lazarus, Jayaprakash Muliyil, Preethi Ragasudha, Mohan Venkata Raghava, Sophy Raju, Anup Ramachandran, Rakhi Ramadas, Karthikeyan Ramanujam, Anuradha Rose, Reeba Roshan, Srujan L Sharma, Shanmuga Sundaram, Rahul J Thomas, William K Pan, Ramya Ambikapathi, J Daniel Carreon, Viyada Doan, Christel Hoest, Stacey Knobler, Mark A Miller, Stephanie Psaki, Zeba Rasmussen, Stephanie A Richard, Karen H Tountas, Erling Svensen, Caroline Amour, Eliwaza Bayyo, Regisiana Mvungi, John Pascal, Ladislaus Yarrot, Leah Barrett, Rebecca Dillingham, William A Petri, Rebecca Scharf, AM Shamsir Ahmed, Md Ashraful Alam, Umma Haque, Md Iqbal Hossain, Munirul Islam, Mustafa Mahfuz, Dinesh Mondal, Baitun Nahar, Fahmida Tofail, Ram Krishna Chandyo, Prakash Sunder Shrestha, Rita Shrestha, Manjeswori Ulak, Aubrey Bauck, Robert Black, Laura Caulfield, William Checkley, Gwenyth Lee, Kerry Schulze, Samuel Scott, Laura E Murray-Kolb, A Catharine Ross, Barbara Schaefer, Suzanne Simons, Laura Pendergast, Cláudia B Abreu, Hilda Costa, Alessandra Di Moura, José Quirino Filho, Álvaro M Leite, Noélia L Lima, Ila F Lima, Bruna LL Maciel, Pedro HQS Medeiros, Milena Moraes, Francisco S Mota, Reinaldo B Oriá, Josiane Quetz, Alberto M Soares, Rosa MS Mota, Crystal L Patil, Cloupas Mahopo, Angelina Maphula, Emanuel Nyathi
Publikováno v:
The Lancet Global Health, Vol 6, Iss 12, Pp e1309-e1318 (2018)
Summary: Background: Optimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnostic methods to reassess and refi
Externí odkaz:
https://doaj.org/article/8ba54b6c559f48a19a10f99f677a66a7