Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution.

Autor: Sukka SR; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. srs2302@columbia.edu., Ampomah PB; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Darville LNF; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Ngai D; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Wang X; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Kuriakose G; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Xiao Y; Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Shi J; Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Koomen JM; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., McCusker RH; Department of Animal Sciences, Integrative Immunology and Behavior Program and Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Tabas I; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. iat1@columbia.edu.; Departments of Physiology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. iat1@columbia.edu.

Publikováno v: Nature metabolism [Nat Metab] 2024 Sep; Vol. 6 (9), pp. 1736-1755. Date of Electronic Publication: 2024 Sep 06.

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease.

Autor: Khaled ML; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Egypt., Ren Y; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Kundalia R; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Alhaddad H; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Chen Z; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Wallace GC; Department of Hematology/Oncology, Georgia Cancer Center at Medical College of Georgia, Augusta, GA, USA., Evernden B; Department of Neuro Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Ospina OE; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Hall M; Department of Immunology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Liu M; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Darville LNF; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Izumi V; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Chen YA; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Pilon-Thomas S; Department of Immunology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Stewart PA; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Koomen JM; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.; Department of Molecular Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Corallo SA; Department of Blood and Marrow Transplant and Cellular Immunotherapy, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Jain MD; Department of Blood and Marrow Transplant and Cellular Immunotherapy, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Robinson TJ; Therapeutic Radiology, Smilow Cancer Hospital at Yale New Haven, 35 Park Street, New Haven, CT, USA., Locke FL; Department of Blood and Marrow Transplant and Cellular Immunotherapy, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Forsyth PA; Department of Neuro Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.; The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Smalley I; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 18. Date of Electronic Publication: 2023 Dec 18.

Dose-escalation trial of combination dabrafenib, trametinib, and AT13387 in patients with BRAF-mutant solid tumors.

Autor: Mooradian MJ; Division of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Cleary JM; Harvard Medical School, Boston, Massachusetts, USA.; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Giobbie-Hurder A; Division of Biostatistics, Departments of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Darville LNF; Department of Proteomics and Metabolomics Core, Moffitt Cancer Center, Tampa, Florida, USA., Parikh A; Division of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Buchbinder EI; Harvard Medical School, Boston, Massachusetts, USA.; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Cohen JV; Division of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Lawrence DP; Division of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Shapiro GI; Harvard Medical School, Boston, Massachusetts, USA.; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Keer H; Astex Pharmaceuticals Inc., Pleasanton, California, USA., Chen HX; Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA., Ivy SP; Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA., Smalley KSM; Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida, USA., Koomen JM; Department of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida, USA., Sullivan RJ; Division of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Cancer [Cancer] 2023 Jun 15; Vol. 129 (12), pp. 1904-1918. Date of Electronic Publication: 2023 Apr 11.

Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution.

Autor: Ampomah PB; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. pbampomah1@gmail.com.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA. pbampomah1@gmail.com., Cai B; Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sukka SR; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Gerlach BD; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Yurdagul A Jr; Department of Molecular and Cellular Physiology, LSU Health Shreveport, Shreveport, LA, USA., Wang X; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Kuriakose G; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Darville LNF; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Sun Y; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA., Sidoli S; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA., Koomen JM; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Tall AR; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Tabas I; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. iat1@columbia.edu.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. iat1@columbia.edu.; Department of Physiology, Columbia University Irving Medical Center, New York, NY, USA. iat1@columbia.edu.

Publikováno v: Nature metabolism [Nat Metab] 2022 Apr; Vol. 4 (4), pp. 444-457. Date of Electronic Publication: 2022 Mar 31.

LC-HRMS of derivatized urinary estrogens and estrogen metabolites in postmenopausal women.

Autor: Darville LNF; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States. Electronic address: Lancia.Darville@moffitt.org., Cline JK; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Rozmeski C; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Martinez YC; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Rich S; University of Florida, Gainesville, FL, United States., Eschrich SA; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Egan KM; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States. Electronic address: Kathleen.Egan@moffitt.org., Yaghjyan L; University of Florida, Gainesville, FL, United States., Koomen JM; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 Oct 01; Vol. 1154, pp. 122288. Date of Electronic Publication: 2020 Jul 29.