Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Dart, MJ"'
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Peripheral and central sites of action for the non-selective cannabinoid agonist WIN 55,212-2 in a rat model of post-operative pain
Autor: Zhu, CZ, Mikusa, JP, Fan, Y, Hollingsworth, PR, Pai, M, Chandran, P, Daza, AV, Yao, BB, Dart, MJ, Meyer, MD, Decker, MW, Hsieh, GC, Honore, P
Activation of cannabinoid (CB) receptors decreases nociceptive transmission in inflammatory or neuropathic pain states. However, the effects of CB receptor agonists in post-operative pain remain to be investigated. Here, we characterized the anti-all
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bdd5bac3522a04ace644cad4ae1a6e6
https://europepmc.org/articles/PMC2707976/
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2
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors
Autor: Curzon P, Carol S. Surowy, Dart Mj, Ryther Kb, Cao Yj, Michael J. Buckley, M R Schrimpf, Frost Jm, William H. Bunnelle, Ji Jianquo, Arianna Gelain, Puttfarcken P, Anderson Dj, Meyer, Lucio Toma, Searle X, Putman Cb, Daanen Jf, Daniela Barlocco
Publikováno v: Journal of medicinal chemistry. 50(15)
A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-digit-picomolar binding affinities for the alpha 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6772a360b44e591cfd2021bbd0f4a4b6
https://pubmed.ncbi.nlm.nih.gov/17585748
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3
Akademický článek
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4
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5
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6
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7
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8
Akademický článek
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo .
Autor: Randolph JT; Abbvie Inc., North Chicago, Illinois 60064, United States., O'Connor MJ; Abbvie Inc., North Chicago, Illinois 60064, United States., Han F; Abbvie Inc., North Chicago, Illinois 60064, United States., Hutchins CW; Abbvie Inc., North Chicago, Illinois 60064, United States., Siu YA; Abbvie Inc., North Chicago, Illinois 60064, United States., Cho M; Calico Life Sciences LLC, South San Francisco, California 94080, United States., Zheng Y; Abbvie Inc., North Chicago, Illinois 60064, United States., Hickson JA; Abbvie Inc., North Chicago, Illinois 60064, United States., Markley JL; Abbvie Inc., North Chicago, Illinois 60064, United States., Manaves V; Abbvie Inc., North Chicago, Illinois 60064, United States., Algire M; Abbvie Inc., North Chicago, Illinois 60064, United States., Baker KA; Abbvie Inc., North Chicago, Illinois 60064, United States., Chapman AM; Abbvie Inc., North Chicago, Illinois 60064, United States., Gopalakrishnan SM; Abbvie Inc., North Chicago, Illinois 60064, United States., Panchal SC; Abbvie Inc., North Chicago, Illinois 60064, United States., Foster-Duke K; Abbvie Inc., North Chicago, Illinois 60064, United States., Stolarik DF; Abbvie Inc., North Chicago, Illinois 60064, United States., Kempf-Grote A; Abbvie Inc., North Chicago, Illinois 60064, United States., Dammeier D; Abbvie Inc., North Chicago, Illinois 60064, United States., Fossey S; Abbvie Inc., North Chicago, Illinois 60064, United States., Sun Q; Abbvie Inc., North Chicago, Illinois 60064, United States., Sun C; Abbvie Inc., North Chicago, Illinois 60064, United States., Shen Y; Abbvie Inc., North Chicago, Illinois 60064, United States., Dart MJ; Abbvie Inc., North Chicago, Illinois 60064, United States., Kati WM; Abbvie Inc., North Chicago, Illinois 60064, United States., Lai A; Abbvie Inc., North Chicago, Illinois 60064, United States., Firestone AJ; Calico Life Sciences LLC, South San Francisco, California 94080, United States., Kort ME; Abbvie Inc., North Chicago, Illinois 60064, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Mar 23; Vol. 66 (6), pp. 3852-3865. Date of Electronic Publication: 2023 Mar 06.
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9
Akademický článek
eIF2B activator prevents neurological defects caused by a chronic integrated stress response.
Autor: Wong YL; Calico Life Sciences LLC, South San Francisco, United States., LeBon L; Calico Life Sciences LLC, South San Francisco, United States., Basso AM; AbbVie, North Chicago, United States., Kohlhaas KL; AbbVie, North Chicago, United States., Nikkel AL; AbbVie, North Chicago, United States., Robb HM; AbbVie, North Chicago, United States., Donnelly-Roberts DL; AbbVie, North Chicago, United States., Prakash J; AbbVie, North Chicago, United States., Swensen AM; AbbVie, North Chicago, United States., Rubinstein ND; Calico Life Sciences LLC, South San Francisco, United States., Krishnan S; Calico Life Sciences LLC, South San Francisco, United States., McAllister FE; Calico Life Sciences LLC, South San Francisco, United States., Haste NV; Calico Life Sciences LLC, South San Francisco, United States., O'Brien JJ; Calico Life Sciences LLC, South San Francisco, United States., Roy M; Calico Life Sciences LLC, South San Francisco, United States., Ireland A; Calico Life Sciences LLC, South San Francisco, United States., Frost JM; AbbVie, North Chicago, United States., Shi L; AbbVie, North Chicago, United States., Riedmaier S; AbbVie, North Chicago, United States., Martin K; Calico Life Sciences LLC, South San Francisco, United States., Dart MJ; AbbVie, North Chicago, United States., Sidrauski C; Calico Life Sciences LLC, South San Francisco, United States.
Publikováno v: ELife [Elife] 2019 Jan 09; Vol. 8. Date of Electronic Publication: 2019 Jan 09.
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10
Akademický článek
TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats.
Autor: McGaraughty S; Neuroscience Research, AbbVie, North Chicago, Illinois Steve.P.McGaraughty@abbvie.com., Chu KL; Neuroscience Research, AbbVie, North Chicago, Illinois., Xu J; Neuroscience Research, AbbVie, North Chicago, Illinois., Leys L; Neuroscience Research, AbbVie, North Chicago, Illinois., Radek RJ; Neuroscience Research, AbbVie, North Chicago, Illinois., Dart MJ; Neuroscience Research, AbbVie, North Chicago, Illinois., Gomtsyan A; Neuroscience Research, AbbVie, North Chicago, Illinois., Schmidt RG; Neuroscience Research, AbbVie, North Chicago, Illinois., Kym PR; Neuroscience Research, AbbVie, North Chicago, Illinois., Brederson JD; Neuroscience Research, AbbVie, North Chicago, Illinois.
Publikováno v: Journal of neurophysiology [J Neurophysiol] 2017 Aug 01; Vol. 118 (2), pp. 904-916. Date of Electronic Publication: 2017 May 03.
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