Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Darson Lai"'
Autor:
Beisi Xu, Darson Lai, Dustin E. Schones, Suresh Cuddapah, Takamitsu Hattori, Ramya K. Mallela, Cynthia C. Jose, Shohei Koide, Candi Trac, Lakshmanan Jagannathan
Publikováno v:
Proceedings of the National Academy of Sciences. 111:14631-14636
Investigations into the genomic landscape of histone modifications in heterochromatic regions have revealed histone H3 lysine 9 dimethylation (H3K9me2) to be important for differentiation and maintaining cell identity. H3K9me2 is associated with gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168479a6bd06b94ca9df9994c0c0bf42
https://doi.org/10.1073/pnas.1406923111
https://doi.org/10.1073/pnas.1406923111
Autor:
Neil L. Kelleher, Takamitsu Hattori, Kohei Kurosawa, Irina Dementieva, Brian D. Strahl, Darson Lai, Alexander J. Ruthenburg, Sherwin P. Montaño, Kalina M. Świst-Rosowska, Akiko Koide, Krzysztof Krajewski, Shohei Koide, Adrian T. Grzybowski, Louesa R. Akin, Yupeng Zheng
Antibodies have a well-established modular architecture wherein the antigen-binding site residing in the antigen-binding fragment (Fab or Fv) is an autonomous and complete unit for antigen recognition. Here, we describe antibodies departing from this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d123fef2e4818b7cea2d5d20788169
Autor:
Marcin Paduch, Tet Matsuguchi, Debbie Dong, Jason Moffat, Stephen Anderson, Susanne Gräslund, Jay S Goodman, Svitlana Usatyuk, Shane Miersch, Anthony A. Kossiakoff, Judy Luke, Carly Griffin, Nan Zhong, Kimberly Perry, Vince Lu, Zhijian Li, Robert J. Hoey, Shohei Koide, Allison K. Doak, Franco J. Vizeacoumar, James A. Wells, Annika Sääf, Sachdev S. Sidhu, Michael Hornsby, Karolina Wypisniak, Elliot Campbell, Daniel King, William I. Thomas, Brian Lee, Darson Lai
Publikováno v:
Molecular & Cellular Proteomics : MCP
Antibodies are key reagents in biology and medicine, but commercial sources are rarely recombinant and thus do not provide a permanent and renewable resource. Here, we describe an industrialized platform to generate antigens and validated recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0edf5bba0152cfb998c40c0ba70de0
https://pubmed.ncbi.nlm.nih.gov/26290498
https://pubmed.ncbi.nlm.nih.gov/26290498
Autor:
Delecia R. LaFrance, Mia A. Levy, Melinda E. Sanders, Zengliu Su, Carlos L. Arteaga, William Pao, Liping Du, Kimberly B. Dahlman, Tarah J. Ballinger, Darson Lai, Cindy L. Vnencak-Jones, M. Cooper Lloyd, Vandana G. Abramson, Yu Shyr, Ingrid A. Mayer
Publikováno v:
Breast cancer research and treatment. 145(2)
Mutations in the PIK3CA gene are common in breast cancer and represent a clinically useful therapeutic target. Several larger, population-based studies have shown a positive prognostic significance associated with these mutations. This study aims to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7eebd8a85660fa530678930a36ce1c
https://pubmed.ncbi.nlm.nih.gov/24722917
https://pubmed.ncbi.nlm.nih.gov/24722917
The initiation of epidermal growth factor receptor (EGFR) kinase activity proceeds via an asymmetric dimerization mechanism in which a “donor” tyrosine kinase domain (TKD) contacts an “acceptor” TKD, leading to its activation. In the context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93be378e4a2473142bd9cbc6200c93b5
https://europepmc.org/articles/PMC3780914/
https://europepmc.org/articles/PMC3780914/
Autor:
Hattori, Takamitsu, Darson Lai, Dementieva, Irina S., Montaño, Sherwin P., Kurosawa, Kohei, Yupeng Zheng, Akin, Louesa R., Świst-Rosowska, Kalina M., Grzybowski, Adrian T., Koide, Akiko, Krajewski, Krzysztof, Strahl, Brian D., Kelleher, Neil L., Ruthenburg, Alexander J., Koide, Shohei
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/23/2016, Vol. 113 Issue 8, p2092-2097, 6p
Autor:
William Pao, Melinda E. Sanders, Vandana G. Abramson, Julie Means-Powell, Maria G. Kuba, Jaime Farley, Carlos L. Arteaga, Ingrid A. Mayer, Cindy Vnenzak-Jones, Darson Lai, Mia A. Levy, Zengliu Su, M. Cooper Lloyd
Publikováno v:
Journal of Clinical Oncology. 31:8-8
8 Background: Mutations in PIK3CA are the most common somatic alterations in breast cancer and represent a potentially useful therapeutic target. As more PI3K pathway inhibitors enter the clinical arena, it is important to understand the characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::896633faa6ba2edea53b72117bd48a68
https://doi.org/10.1200/jco.2013.31.26_suppl.8
https://doi.org/10.1200/jco.2013.31.26_suppl.8
Publikováno v:
Cancer Research. 73:1106-1106
Previous studies have demonstrated that wild-type (WT) EGFRs are activated by an allosteric mechanism in which a ‘donor’ tyrosine kinase domain (TKD) monomer contacts an ‘acceptor’ TKD monomer, leading to its activation. Here, we present bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdf1de81bb7abee0298568014faa1a43
https://doi.org/10.1158/1538-7445.am2013-1106
https://doi.org/10.1158/1538-7445.am2013-1106